ES2069904T3 - Tioeteramidas fenolicas utiles como inhibidores de 5-lipoxigenasa. - Google Patents

Tioeteramidas fenolicas utiles como inhibidores de 5-lipoxigenasa.

Info

Publication number
ES2069904T3
ES2069904T3 ES91915352T ES91915352T ES2069904T3 ES 2069904 T3 ES2069904 T3 ES 2069904T3 ES 91915352 T ES91915352 T ES 91915352T ES 91915352 T ES91915352 T ES 91915352T ES 2069904 T3 ES2069904 T3 ES 2069904T3
Authority
ES
Spain
Prior art keywords
thioetheramides
phenolic
useful
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91915352T
Other languages
English (en)
Inventor
Richard August Mueller
Richard Allen Partis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2069904T3 publication Critical patent/ES2069904T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Abstract

LA PRESENTE INVENCION SE REFIERE A TIOETERAMIDAS FENOLICAS DE LA FORMULA (I) EN DONDE R1 Y R2 SON TERC-ALQUILO O FENILO, ALK1 Y ALK2 SON ALQUILENO; X ES AZUFRE U OXIGENO, M ES 0, 1 O 2; Y R ES A) EN DONDE R3 Y R4 SON HIDROGENO O ALQUILO Y ALK3 ES ALQUILENO; O B) EN DONDE Y ES CH, N, O O S; R6 ES HIDROGENO, ALQUILO, FENILO, FENILO SUSTITUIDO, BENCILO, BENCILO SUSTITUIDO O UNA AMINA HETEROCICLICA; Y R7 ES HIDROGENO O ALQUILO. LOS COMPUESTOS INHIBEN LA 5-LIPOXIGENASA Y SON UTILES PARA EL TRATAMIENTO DE CONDICIONES INFLAMATORIAS Y ALERGICAS.
ES91915352T 1990-09-07 1991-09-05 Tioeteramidas fenolicas utiles como inhibidores de 5-lipoxigenasa. Expired - Lifetime ES2069904T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57912490A 1990-09-07 1990-09-07

Publications (1)

Publication Number Publication Date
ES2069904T3 true ES2069904T3 (es) 1995-05-16

Family

ID=24315668

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91915352T Expired - Lifetime ES2069904T3 (es) 1990-09-07 1991-09-05 Tioeteramidas fenolicas utiles como inhibidores de 5-lipoxigenasa.

Country Status (12)

Country Link
US (2) US5298514A (es)
EP (1) EP0547090B1 (es)
JP (1) JPH06500328A (es)
AT (1) ATE119151T1 (es)
AU (1) AU8440991A (es)
CA (1) CA2088503A1 (es)
DE (1) DE69107851T2 (es)
ES (1) ES2069904T3 (es)
GR (1) GR3015581T3 (es)
IE (1) IE913143A1 (es)
PT (1) PT98865A (es)
WO (1) WO1992004324A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064781A2 (en) * 2003-01-14 2004-08-05 Adam Heller Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
US7622142B2 (en) * 2004-09-14 2009-11-24 New Chapter Inc. Methods for treating glioblastoma with herbal compositions
NZ624963A (en) 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1936463A1 (de) * 1969-07-17 1971-02-04 Boehringer Sohn Ingelheim Substituierte Phenole
AT353776B (de) * 1973-12-27 1979-12-10 Siegfried Ag Verfahren zur herstellung von neuen alkan- saeuren, deren estern und salzen
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
DE3324916A1 (de) * 1983-07-09 1985-01-17 Boehringer Mannheim Gmbh, 6800 Mannheim Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4663333A (en) * 1985-02-04 1987-05-05 G. D. Searle & Co. Acylaminoalkylpyridines ad use in treatment of inflammation and allergy reactions
DE3685829T2 (de) * 1985-02-04 1992-12-17 Searle & Co Heterocyclische amide.
EP0190682B1 (en) * 1985-02-04 1990-09-12 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
EP0339688B1 (en) * 1985-05-20 1993-03-10 G.D. Searle & Co. Hydroxyphenylthioalkylketones
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase
US4711903A (en) * 1986-01-31 1987-12-08 G. D. Searle & Co. Phenolic thioethers as inhibitors of 5-lipoxygenase
US5010080A (en) * 1988-12-02 1991-04-23 G. D. Searle & Co. Use of heterocyclic amides to inhibit tumor metastasis
US5030642A (en) * 1988-12-02 1991-07-09 G. D. Searle & Co. Acylaminoalkylpyridineamides as inhibitors of metastasis

Also Published As

Publication number Publication date
EP0547090B1 (en) 1995-03-01
US5342838A (en) 1994-08-30
JPH06500328A (ja) 1994-01-13
US5298514A (en) 1994-03-29
CA2088503A1 (en) 1992-03-08
GR3015581T3 (en) 1995-06-30
DE69107851D1 (en) 1995-04-06
DE69107851T2 (de) 1995-08-03
AU8440991A (en) 1992-03-30
WO1992004324A1 (en) 1992-03-19
IE913143A1 (en) 1992-03-11
PT98865A (pt) 1992-07-31
ATE119151T1 (de) 1995-03-15
EP0547090A1 (en) 1993-06-23

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