ES2064391T3 - Adn que codifica un polipeptido anticoagulante. - Google Patents
Adn que codifica un polipeptido anticoagulante.Info
- Publication number
- ES2064391T3 ES2064391T3 ES89113261T ES89113261T ES2064391T3 ES 2064391 T3 ES2064391 T3 ES 2064391T3 ES 89113261 T ES89113261 T ES 89113261T ES 89113261 T ES89113261 T ES 89113261T ES 2064391 T3 ES2064391 T3 ES 2064391T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptide
- cpbii
- placent
- human
- dna fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN POLIPEPTIDO TENIENDO UNA CADENA DE AMINOACIDOS COMO MUESTRA LA FIGURA 1 Y SU METODO DE PREPARACION SON PRESENTADOS. UN FRAGMENTO DE DNA CAPAZ DE CODIFICAR EL POLIPEPTIDO CPBII (INHIBIDOR DE LA COAGULACION DERIVADO DE LA PLACENTA HUMANA) ES OBTENIDO PRIMERO UN LIBRADOR CDNA DE LA PLACENTA HUMANA USANDO EL ANTICUERPO CPBII-ESPECIFICO COMO UNA SONDA. ENTONCES, LAS CELULAS DE LOS MICROORGANISMOS SON TRANSFORMADOS MEDIANTE EL USO DE UN PLASMIDO RECOMBINANTE INCORPORADO AL FRAGMENTO DE DNA, PERMITIENDO QUE EL TRANSFORMANTE RESULTANTE EXPRESE EL GEN CPBII, PARA FINALMENTE OBTENER UN POLIPEPTIDO SEMEJANTE AL CPBII. EL POLIPEPTIDO DE ESTA INVENCION PRESENTA FUERTES ACTIVIDADES ANTICOAGULANTES Y ES UTIL COMO COMPONENTE ACTIVO DE MEDICINAS ANTICOAGULANTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63182633A JP2701047B2 (ja) | 1988-07-21 | 1988-07-21 | 抗血液凝固作用を有するポリペプチド |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064391T3 true ES2064391T3 (es) | 1995-02-01 |
Family
ID=16121703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89113261T Expired - Lifetime ES2064391T3 (es) | 1988-07-21 | 1989-07-19 | Adn que codifica un polipeptido anticoagulante. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0351826B1 (es) |
JP (1) | JP2701047B2 (es) |
KR (1) | KR970005913B1 (es) |
CA (1) | CA1338401C (es) |
DE (1) | DE68918519T2 (es) |
ES (1) | ES2064391T3 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
US5968477A (en) * | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
CA2190727C (en) * | 1994-05-19 | 2006-07-18 | Sudhakar Kasina | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging |
US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
DE10162434A1 (de) * | 2001-12-18 | 2003-09-25 | November Ag Molekulare Medizin | Expressionsvektor und Verfahren zur Herstellung eines Expressionsvektors |
KR20100020236A (ko) * | 2008-08-12 | 2010-02-22 | 세기 리미티드 | 센서를 구비한 차량용 무선통신장치 및 차량 제어시스템 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0764878B2 (ja) * | 1986-10-14 | 1995-07-12 | 興和株式会社 | 抗血液凝固物質及びその製法 |
-
1988
- 1988-07-21 JP JP63182633A patent/JP2701047B2/ja not_active Expired - Fee Related
-
1989
- 1989-07-15 KR KR1019890010107A patent/KR970005913B1/ko active IP Right Grant
- 1989-07-19 EP EP89113261A patent/EP0351826B1/en not_active Expired - Lifetime
- 1989-07-19 DE DE68918519T patent/DE68918519T2/de not_active Expired - Fee Related
- 1989-07-19 ES ES89113261T patent/ES2064391T3/es not_active Expired - Lifetime
- 1989-07-20 CA CA000606253A patent/CA1338401C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR970005913B1 (ko) | 1997-04-22 |
JPH0232099A (ja) | 1990-02-01 |
JP2701047B2 (ja) | 1998-01-21 |
CA1338401C (en) | 1996-06-18 |
EP0351826A3 (en) | 1990-05-23 |
EP0351826B1 (en) | 1994-09-28 |
DE68918519D1 (de) | 1994-11-03 |
KR900001847A (ko) | 1990-02-27 |
DE68918519T2 (de) | 1995-05-11 |
EP0351826A2 (en) | 1990-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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