ES2063102T3 - Imidazoles para el tratamiento de la aterosclerosis. - Google Patents
Imidazoles para el tratamiento de la aterosclerosis.Info
- Publication number
- ES2063102T3 ES2063102T3 ES89122302T ES89122302T ES2063102T3 ES 2063102 T3 ES2063102 T3 ES 2063102T3 ES 89122302 T ES89122302 T ES 89122302T ES 89122302 T ES89122302 T ES 89122302T ES 2063102 T3 ES2063102 T3 ES 2063102T3
- Authority
- ES
- Spain
- Prior art keywords
- imidazoles
- atherosclerosis
- treatment
- imizers
- colestaeros
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
ESTE INVENTO NOS DESCUBRE A LOS IMIZADORES COMO INHIBIDORES DEL ACIL - COA, COLESTAEROS ACILTRANFERASA (ACAT), TRATADO PARA SU PREPARACION, Y SU USO COMO UN AGENTE ANTIPERCOLESTEROLEMICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27998188A | 1988-12-05 | 1988-12-05 | |
US41660689A | 1989-10-10 | 1989-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2063102T3 true ES2063102T3 (es) | 1995-01-01 |
Family
ID=26960005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89122302T Expired - Lifetime ES2063102T3 (es) | 1988-12-05 | 1989-12-03 | Imidazoles para el tratamiento de la aterosclerosis. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0372445B1 (es) |
JP (1) | JPH0662583B2 (es) |
KR (1) | KR910009939B1 (es) |
AU (1) | AU628890B2 (es) |
CA (1) | CA2003283A1 (es) |
DE (1) | DE68913667T2 (es) |
DK (1) | DK609489A (es) |
ES (1) | ES2063102T3 (es) |
FI (1) | FI895781A0 (es) |
HU (1) | HU205916B (es) |
IL (1) | IL92533A0 (es) |
NO (1) | NO894842L (es) |
NZ (1) | NZ231605A (es) |
PT (1) | PT92484B (es) |
RU (2) | RU2028293C1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
GB9005966D0 (en) * | 1990-03-16 | 1990-05-09 | May & Baker Ltd | New compositions of matter |
US5220041A (en) * | 1991-03-04 | 1993-06-15 | Eastman Kodak Company | Sulfonate ester |
US5212318A (en) * | 1991-03-04 | 1993-05-18 | Eastman Kodak Company | Preparation of omega-substituted alkanamide |
US5179117A (en) * | 1991-12-20 | 1993-01-12 | Du Pont Merck Pharmaceutical Company | Antihypercholesterolemic 2-substituted imidazoles |
CA2085844A1 (en) * | 1991-12-27 | 1993-06-28 | Nobuyuki Hamanaka | Fused benzeneoxyacetic acid derivatives |
US5310748A (en) * | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
US5358946A (en) * | 1992-05-29 | 1994-10-25 | The Du Pont Merck Pharmaceutical Company | Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis |
US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
US6426360B1 (en) | 1994-07-28 | 2002-07-30 | G D Searle & Co. | 4,5-substituted imidazolyl compounds for the treatment of inflammation |
CA2223154A1 (en) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6515014B2 (en) | 1995-06-02 | 2003-02-04 | G. D. Searle & Co. | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
AU2404897A (en) | 1996-04-24 | 1997-11-12 | Takeda Chemical Industries Ltd. | Fused imidazopyridine derivatives as antihyperlipidemic agents |
JP4191269B2 (ja) * | 1996-05-17 | 2008-12-03 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
US6677364B2 (en) | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
ATE297900T1 (de) * | 1997-03-25 | 2005-07-15 | Kowa Co | Anilidverbindungen und medikamente, die diese enthalten |
US6969711B2 (en) | 1997-05-26 | 2005-11-29 | Kowa Company, Ltd. | Cyclic diamine compounds and medicine containing the same |
ATE285402T1 (de) * | 1997-05-26 | 2005-01-15 | Kowa Co | Neue zyklische diaminverbindungen und heilmittel das diese enthält |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
US7329401B2 (en) | 2002-04-15 | 2008-02-12 | The Regents Of The University Of California | Cyclooxygenase-2 selective agents useful as imaging probes and related methods |
HRP20020440B1 (en) | 2002-05-21 | 2008-02-29 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof |
HRP20020452A2 (en) | 2002-05-23 | 2004-02-29 | Pliva D D | 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
HRP20020453A2 (en) | 2002-05-23 | 2003-12-31 | Pliva D D | 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
DE10238045A1 (de) | 2002-08-20 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
AU2003300099A1 (en) | 2003-01-02 | 2004-07-29 | Millennium Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING TGF-Beta |
EP1939181A1 (en) * | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4137234A (en) * | 1971-03-09 | 1979-01-30 | Smith Kline & French Laboratories Limited | Thiazole, isothiazole, oxazole and isoxazole substituted thiourea and urea compounds |
US4198421A (en) * | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3323870A1 (de) * | 1983-07-02 | 1985-01-03 | A. Nattermann & Cie GmbH, 5000 Köln | Neue imidazol-2-ylthioalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3504680A1 (de) * | 1985-02-12 | 1986-08-14 | A. Nattermann & Cie GmbH, 5000 Köln | Neue ether des 2-hydroxyimidazols, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3504677A1 (de) * | 1985-02-12 | 1986-08-14 | A. Nattermann & Cie GmbH, 5000 Köln | Neue imidazol-2-yloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
DK171349B1 (da) * | 1986-11-14 | 1996-09-16 | Hoffmann La Roche | Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler |
US4882348A (en) * | 1987-12-29 | 1989-11-21 | Smithkline Beckman Corporation | 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
-
1989
- 1989-11-17 CA CA002003283A patent/CA2003283A1/en not_active Abandoned
- 1989-12-01 NZ NZ231605A patent/NZ231605A/xx unknown
- 1989-12-03 DE DE68913667T patent/DE68913667T2/de not_active Expired - Fee Related
- 1989-12-03 ES ES89122302T patent/ES2063102T3/es not_active Expired - Lifetime
- 1989-12-03 EP EP89122302A patent/EP0372445B1/en not_active Expired - Lifetime
- 1989-12-04 NO NO89894842A patent/NO894842L/no unknown
- 1989-12-04 PT PT92484A patent/PT92484B/pt not_active IP Right Cessation
- 1989-12-04 KR KR1019890017841A patent/KR910009939B1/ko not_active IP Right Cessation
- 1989-12-04 DK DK609489A patent/DK609489A/da not_active Application Discontinuation
- 1989-12-04 IL IL92533A patent/IL92533A0/xx unknown
- 1989-12-04 RU SU894742800A patent/RU2028293C1/ru active
- 1989-12-04 JP JP1313553A patent/JPH0662583B2/ja not_active Expired - Lifetime
- 1989-12-04 FI FI895781A patent/FI895781A0/fi not_active Application Discontinuation
- 1989-12-05 HU HU896428A patent/HU205916B/hu not_active IP Right Cessation
- 1989-12-05 AU AU45930/89A patent/AU628890B2/en not_active Ceased
-
1991
- 1991-01-25 RU SU914894323A patent/RU2026292C1/ru active
Also Published As
Publication number | Publication date |
---|---|
NO894842D0 (no) | 1989-12-04 |
AU628890B2 (en) | 1992-09-24 |
IL92533A0 (en) | 1990-08-31 |
AU4593089A (en) | 1990-06-07 |
DE68913667T2 (de) | 1994-07-14 |
PT92484B (pt) | 1995-08-09 |
HUT54121A (en) | 1991-01-28 |
DE68913667D1 (de) | 1994-04-14 |
EP0372445A1 (en) | 1990-06-13 |
CA2003283A1 (en) | 1990-06-05 |
FI895781A0 (fi) | 1989-12-04 |
NO894842L (no) | 1990-06-06 |
KR900009604A (ko) | 1990-07-05 |
HU205916B (en) | 1992-07-28 |
EP0372445B1 (en) | 1994-03-09 |
DK609489D0 (da) | 1989-12-04 |
DK609489A (da) | 1990-06-06 |
JPH0662583B2 (ja) | 1994-08-17 |
RU2028293C1 (ru) | 1995-02-09 |
KR910009939B1 (ko) | 1991-12-06 |
JPH02237980A (ja) | 1990-09-20 |
PT92484A (pt) | 1990-06-29 |
NZ231605A (en) | 1991-09-25 |
RU2026292C1 (ru) | 1995-01-09 |
HU896428D0 (en) | 1990-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2063102T3 (es) | Imidazoles para el tratamiento de la aterosclerosis. | |
PA8468401A1 (es) | Compuestos para el tratamiento de la isquemia | |
ES2018706B3 (es) | Composicion polimera, un procedimiento para obtener una composicion polimera y el uso de dicha composicion. | |
ES2195970T3 (es) | L-ribavirina y usos de la misma. | |
IT8684947A0 (it) | Mandrino autoserrante per trapani ed apparecchiature simili, particolarmente adatto per trapani portatili ad uso chirurgico. | |
PT797439E (pt) | Utilizacao de pramipexote como agente neuroprotector | |
ES2177601T3 (es) | Ranolazina y pepeerazinas relacionadas para uso en el tratamiento de estados de choque. . | |
ES540645A0 (es) | Aparato para el tratamiento del plasma. | |
ES505721A0 (es) | Procedimiento de obtencion de una composicion a base de derivados de urea para el tratamiento de textiles. | |
AR016981A2 (es) | Polipeptidos sinteticos | |
ECSP034766A (es) | Una combinacion que comprende combretastatina y agentes anticancerigenos | |
IT8019513A0 (it) | Apparecchiatura per il trattamento del plasma. | |
ES2133412T3 (es) | 2',5'-oligoadenilato-2',3'-ciclofosfatos y 2',5'-oligoadenilatos con actividad sobre el virus papiloma. | |
ES2013631B3 (es) | Metodo para el tratamiento de tejidos. | |
ES2167678T3 (es) | Tratamiento y profilaxis de la pancreatitis. | |
ES2177811T3 (es) | Uso de nitroflavonoides para el tratamiento de la ansiedad. | |
ES2196069T3 (es) | Derivados morfinoides condensados con heterociclos. | |
FI872833A0 (fi) | Anordning foer att aostadkomma lokalt verkande tryckkrafter pao en glasskiva innanfoer konturerna foer den bilglasskiva som utskaers. | |
ES2136628T3 (es) | 4-iminoquinolinas, procedimiento para su preparacion y su empleo. | |
ES2052850T3 (es) | Un procedimiento para preparar un compuesto de hidrazona. | |
AR008860A1 (es) | Empleo de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica | |
FI881510A (fi) | Material baserat pao fibertyg, som kan anvaendas saosom foerstaerkningsinlaeggning i taetande reveteringar. | |
AR005704A1 (es) | Heteroariloxazolidinonas | |
ES2175661T3 (es) | Derivados de la isoflavona, procedimientos para la preparacion de los mismos y composiciones farmaceuticas que los contienen. | |
UY24915A1 (es) | Derivados de benzoxazindiona, aplicación de los mismos y medicamentos que los contienen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 372445 Country of ref document: ES |