ES2062432T3 - Nuevos derivados de la 1h,3h-pirrolo(1,2-c)tiazolcarboxamida-7, su preparacion y las composiciones farmaceuticas que les contienen. - Google Patents

Nuevos derivados de la 1h,3h-pirrolo(1,2-c)tiazolcarboxamida-7, su preparacion y las composiciones farmaceuticas que les contienen.

Info

Publication number
ES2062432T3
ES2062432T3 ES90400704T ES90400704T ES2062432T3 ES 2062432 T3 ES2062432 T3 ES 2062432T3 ES 90400704 T ES90400704 T ES 90400704T ES 90400704 T ES90400704 T ES 90400704T ES 2062432 T3 ES2062432 T3 ES 2062432T3
Authority
ES
Spain
Prior art keywords
phenyl
alkyl
phenylalkyl
pyridyl
hydroxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90400704T
Other languages
English (en)
Inventor
Claude James
Daniel Lave
Francoise Soler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Application granted granted Critical
Publication of ES2062432T3 publication Critical patent/ES2062432T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

NUEVOS DERIVADOS DE FORMULA (I), EN LA QUE R1 = H, HALOGENO, ALCOILO, ALCOXILO CF3, NH2, ALCOILAMINO, DIALCOILAMINO, OH, CH, FENILO O FENOXI; AR = FENILO, NAFTILO, PIRIDILO, QUINOLILO, ISOQUINOLILO, TIENILO, TIENO [2,3-B]TIENILO O TIENEO [2,3-B]TIENILO (EVENTUALMENTE SUSTITUIDOS POR HALOGENO, ALCOILO, ALCOILOXI, CF3, NH2, ALCOILAMINO, DIALCOILAMINO, OH O CN; P = 0, 1 O 2; Y A) Z ES UNION DE VALENCIA Y R2 = H, B) Z ES UNION DE VALENCIA Y R2 = PIRIDILO, QUINUCLIDINILO, PIRROLIDINILO-3, PIPERIDILO-3 O -4 (EVENTUALMENTE SUSTITUIDOS POR ALCOILO, HIDROXIALCOILO, FENILO O FENILALCOILO), C) Z ES RADICAL ALCOILENO C1-C4 Y R2 = PIRIDILO-2, -3 O -4, QUINUCLIDINILO-3, PIRROLIDINILO-2 O -3, PIPERIDILO-2, -3 O -4 (EVENTUALMENTE SUSTITUIDO POR ALCOILO, HIDROXIALCOILO, FENILO O FENILALCOILO) O R2 = CON(R3)(R4), DONDE A) R3 Y R4 FORMAN UNA PIPERAZINA EVENTUALMENTE SUSTITUIDA POR ALCOILO, HIDROXIALCOILO, PIRIDILO, FENILO O FENILALCOILO, B) R3 = HALCOILO, FENILO O FENILALCOILO O (CH2)NN(R5)(R6), DONDE 1 < N< 4 Y R5 Y R6 = H, ALCOILO, FENILO, FENILALCOILO, O R5 Y R6 FORMAN UN CICLO DE MORFOLINA, TIOMORFOLINA, PIRROLIDINA, PIPERIDINA O PIPERAZINA (EVENTUALMENTE SUSTITUIDA POR ALCOILO, HIDROXIALCOILO, PIRIDILO, FENILO, FENILALCOILO O FENILCARBONILO), Y R4 = (CH2)NN(R5)(R6) DEFINIDO COMO ANTERIORMENTE; D) Z ES ALCOILENO C1-C4 Y R2 = N(R3)(R4) O N(R5)(R6), DONDE R3, R4, R5 Y R6 SE DEFINEN COMO ANTERIORMENTE EN C), B) ENTENDIENDO QUE LOS ALCOILOS CONTIENEN 1-4 C, DE CADENA RECTA O RAMIFICADA, Y QUE LA INVENCION SE REFIERE A LOS RACEMICOS, LOS ENANTIOMEROS Y SUS MEZCLAS, LOS DIASTEROISOMEROS PUROS O EN MEZCLA, LOS ISOMEROS E Y Z, ASI COMO LAS SALES DE ESTOS PRODUCTOS.
ES90400704T 1989-03-17 1990-03-16 Nuevos derivados de la 1h,3h-pirrolo(1,2-c)tiazolcarboxamida-7, su preparacion y las composiciones farmaceuticas que les contienen. Expired - Lifetime ES2062432T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8903510A FR2644456B1 (fr) 1989-03-17 1989-03-17 Nouveaux derives du 1h, 3h-pyrrolo(1,2-c)thiazolecarboxamide-7, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2062432T3 true ES2062432T3 (es) 1994-12-16

Family

ID=9379793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90400704T Expired - Lifetime ES2062432T3 (es) 1989-03-17 1990-03-16 Nuevos derivados de la 1h,3h-pirrolo(1,2-c)tiazolcarboxamida-7, su preparacion y las composiciones farmaceuticas que les contienen.

Country Status (24)

Country Link
US (1) US5086051A (es)
EP (1) EP0388309B1 (es)
JP (1) JPH02289586A (es)
KR (1) KR900014408A (es)
AT (1) ATE102210T1 (es)
BG (1) BG51159A3 (es)
CA (1) CA2012343A1 (es)
CS (2) CS438990A3 (es)
DD (1) DD297822A5 (es)
DE (1) DE69006872T2 (es)
DK (1) DK0388309T3 (es)
ES (1) ES2062432T3 (es)
FI (1) FI92069C (es)
FR (1) FR2644456B1 (es)
IE (1) IE63313B1 (es)
IL (1) IL93760A (es)
MA (1) MA21771A1 (es)
MX (1) MX26542A (es)
NO (1) NO172392C (es)
NZ (1) NZ232960A (es)
PL (1) PL284321A1 (es)
PT (1) PT93485B (es)
TN (1) TNSN90030A1 (es)
ZA (1) ZA902033B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW214545B (es) * 1992-02-17 1993-10-11 Ciba Geigy Ag
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
CA2140034A1 (en) 1992-07-13 1994-01-20 Xiong Cai 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
TW266206B (es) * 1993-04-28 1995-12-21 Takeda Pharm Industry Co Ltd
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
DE69701298T2 (de) * 1996-04-15 2000-10-05 Takeda Chemical Industries Ltd Hydroxypyridin-Derivate, ihre Herstellung und ihre pharmazeutische Verwendung
US20080266643A1 (en) * 2005-08-19 2008-10-30 National Institute Of Advanced Industrial Science And Technology Electrode for Reversible Color Change Display Device and Method of Producing the Same, and Reversible Color Change Display Device and Reversible Color Change Lighting Control Device
WO2009125434A2 (en) * 2008-04-07 2009-10-15 Cadila Healthcare Limited Oxime derivatives
WO2014192023A1 (en) * 2013-05-22 2014-12-04 Cadila Healthcare Limited Novel compounds suitable for the treatment of dyslipidemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2541280B1 (fr) * 1983-01-13 1985-06-21 Rhone Poulenc Sante Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent
FR2601016B1 (fr) * 1986-07-04 1988-10-07 Rhone Poulenc Sante Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601015B1 (fr) * 1986-07-04 1988-08-05 Rhone Poulenc Sante Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NO901237L (no) 1990-09-18
FI901325A0 (fi) 1990-03-16
CS276785B6 (en) 1992-08-12
DD297822A5 (de) 1992-01-23
MX26542A (es) 1993-09-01
US5086051A (en) 1992-02-04
PT93485B (pt) 1996-02-29
EP0388309A2 (fr) 1990-09-19
PT93485A (pt) 1990-11-07
TNSN90030A1 (fr) 1991-03-05
PL284321A1 (en) 1991-07-29
CA2012343A1 (fr) 1990-09-17
CS438990A3 (en) 1992-03-18
ATE102210T1 (de) 1994-03-15
FR2644456A1 (fr) 1990-09-21
EP0388309B1 (fr) 1994-03-02
IE63313B1 (en) 1995-04-05
FI92069C (fi) 1994-09-26
DK0388309T3 (da) 1994-04-11
BG51159A3 (en) 1993-02-15
NZ232960A (en) 1991-02-26
MA21771A1 (fr) 1990-10-01
DE69006872T2 (de) 1994-06-30
IE900984L (en) 1990-09-17
NO172392B (no) 1993-04-05
ZA902033B (en) 1990-12-28
NO172392C (no) 1993-07-14
CS125290A3 (en) 1992-03-18
KR900014408A (ko) 1990-10-23
IL93760A (en) 1994-08-26
JPH02289586A (ja) 1990-11-29
FR2644456B1 (fr) 1991-07-05
EP0388309A3 (fr) 1991-07-24
NO901237D0 (no) 1990-03-16
IL93760A0 (en) 1990-12-23
FI92069B (fi) 1994-06-15
DE69006872D1 (de) 1994-04-07

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