ES2062336T3 - Derivados de benzoxepina. - Google Patents
Derivados de benzoxepina.Info
- Publication number
- ES2062336T3 ES2062336T3 ES90302745T ES90302745T ES2062336T3 ES 2062336 T3 ES2062336 T3 ES 2062336T3 ES 90302745 T ES90302745 T ES 90302745T ES 90302745 T ES90302745 T ES 90302745T ES 2062336 T3 ES2062336 T3 ES 2062336T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- chem
- benzoxepine derivatives
- benzoxepine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
UN DERIVADO DE BENZOXEPINA REPRESENTADO POR LA FORMULA (I) DONDE R REPRESENTA UN GRUPO HETEROCICLICO Y SALES DEL MISMO, UN PROCESO PARA PRODUCCION DE ESTE COMPRENDE LOS PASOS DE: REDUCIR UN OXIMA REPRESENTADO POR LA FORMULA (V) DONDE R TIENE EL SIGNIFICADO YA DEFINIDO EN LA FORMULA (I) Y LA HIDROLIZACION DEL INTERMEDIRARIO PRODUCIDO POR LA REDUCCION ANTERIOR, Y FARMACOS QUE COMPRENDE EL COMPUESTOS (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1061040A JP2851054B2 (ja) | 1989-03-15 | 1989-03-15 | ベンズオキセピン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062336T3 true ES2062336T3 (es) | 1994-12-16 |
Family
ID=13159742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90302745T Expired - Lifetime ES2062336T3 (es) | 1989-03-15 | 1990-03-14 | Derivados de benzoxepina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5041444A (es) |
EP (1) | EP0388188B1 (es) |
JP (1) | JP2851054B2 (es) |
AT (1) | ATE100097T1 (es) |
DE (1) | DE69005861T2 (es) |
DK (1) | DK0388188T3 (es) |
ES (1) | ES2062336T3 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006026430A2 (en) | 2004-08-27 | 2006-03-09 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
ITMI20042168A1 (it) * | 2004-11-12 | 2005-02-12 | Erregierre Spa | Processo di preparazione di itopride cloridrato |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
JP2010520295A (ja) | 2007-03-07 | 2010-06-10 | インフィニティ・ディスカバリー・インコーポレイテッド | へテロ環状シクロパミン類似体及びその使用方法 |
KR20090117956A (ko) | 2007-03-07 | 2009-11-16 | 인피니티 디스커버리, 인코포레이티드 | 시클로파민 락탐 유사체 및 그의 사용 방법 |
EP2224807B1 (en) | 2007-12-27 | 2016-11-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
EP2247587B1 (en) * | 2008-03-01 | 2014-03-26 | Merck Patent GmbH | 5-oxo-2, 3,4,5-tetrahydro-benzo[b]oxepine-4-carboxylic acid amides and 2,3-dihydro-benzo[b]oxepine-4-carboxylic acid amides for treatment and prevention of diabetes typ 1 and 2 |
ES2567134T3 (es) | 2009-08-05 | 2016-04-20 | Infinity Pharmaceuticals, Inc. | Transaminación enzimática de análogos de ciclopamina |
US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
WO2016019587A1 (en) * | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [7, 6]-fused bicyclic antidiabetic compounds |
WO2016196928A1 (en) | 2015-06-04 | 2016-12-08 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766212A (en) * | 1983-02-15 | 1988-08-23 | Merrell Dow Pharmaceuticals Inc. | 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives |
AU597671B2 (en) * | 1986-06-20 | 1990-06-07 | Suntory Limited | 2-Phenylbenzoxepin derivative |
-
1989
- 1989-03-15 JP JP1061040A patent/JP2851054B2/ja not_active Expired - Lifetime
-
1990
- 1990-03-08 US US07/490,327 patent/US5041444A/en not_active Expired - Fee Related
- 1990-03-14 EP EP90302745A patent/EP0388188B1/en not_active Expired - Lifetime
- 1990-03-14 AT AT90302745T patent/ATE100097T1/de not_active IP Right Cessation
- 1990-03-14 DE DE90302745T patent/DE69005861T2/de not_active Expired - Fee Related
- 1990-03-14 DK DK90302745.6T patent/DK0388188T3/da active
- 1990-03-14 ES ES90302745T patent/ES2062336T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH02243687A (ja) | 1990-09-27 |
DK0388188T3 (da) | 1994-02-14 |
US5041444A (en) | 1991-08-20 |
DE69005861T2 (de) | 1994-04-28 |
JP2851054B2 (ja) | 1999-01-27 |
EP0388188A1 (en) | 1990-09-19 |
DE69005861D1 (de) | 1994-02-24 |
ATE100097T1 (de) | 1994-01-15 |
EP0388188B1 (en) | 1994-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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