DE69005861D1 - Benzoxepin-Derivate. - Google Patents

Benzoxepin-Derivate.

Info

Publication number
DE69005861D1
DE69005861D1 DE90302745T DE69005861T DE69005861D1 DE 69005861 D1 DE69005861 D1 DE 69005861D1 DE 90302745 T DE90302745 T DE 90302745T DE 69005861 T DE69005861 T DE 69005861T DE 69005861 D1 DE69005861 D1 DE 69005861D1
Authority
DE
Germany
Prior art keywords
formula
chem
benzoxepine derivatives
benzoxepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90302745T
Other languages
English (en)
Other versions
DE69005861T2 (de
Inventor
Toshio Tatsuoka
Makoto Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of DE69005861D1 publication Critical patent/DE69005861D1/de
Application granted granted Critical
Publication of DE69005861T2 publication Critical patent/DE69005861T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
DE90302745T 1989-03-15 1990-03-14 Benzoxepin-Derivate. Expired - Fee Related DE69005861T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1061040A JP2851054B2 (ja) 1989-03-15 1989-03-15 ベンズオキセピン誘導体

Publications (2)

Publication Number Publication Date
DE69005861D1 true DE69005861D1 (de) 1994-02-24
DE69005861T2 DE69005861T2 (de) 1994-04-28

Family

ID=13159742

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90302745T Expired - Fee Related DE69005861T2 (de) 1989-03-15 1990-03-14 Benzoxepin-Derivate.

Country Status (7)

Country Link
US (1) US5041444A (de)
EP (1) EP0388188B1 (de)
JP (1) JP2851054B2 (de)
AT (1) ATE100097T1 (de)
DE (1) DE69005861T2 (de)
DK (1) DK0388188T3 (de)
ES (1) ES2062336T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7230004B2 (en) 2004-08-27 2007-06-12 Infinity Discovery, Inc. Cyclopamine analogues and methods of use thereof
ITMI20042168A1 (it) * 2004-11-12 2005-02-12 Erregierre Spa Processo di preparazione di itopride cloridrato
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
EP2129677B1 (de) 2007-03-07 2014-12-17 Infinity Discovery, Inc. Heterocyclische cyclopamin-analoga und verfahren zu ihrer verwendung
RU2009137012A (ru) 2007-03-07 2011-04-20 Инфинити Дискавери, Инк. (Us) Аналоги циклопаминлактама и способы их применения
ES2717797T3 (es) 2007-12-27 2019-06-25 Infinity Pharmaceuticals Inc Métodos para reducción estereoselectiva de derivados de 4-en-3-ona de ciclopamina
US8383838B2 (en) * 2008-03-01 2013-02-26 MERCK Patent Gesellschaft mit beschränkter Haftung 5-oxo-2,3,4,5-tetrahydro-benzo[b]oxepine-4-carboxylic acid amides and 2,3-dihydro-benzo[b]oxepine-4-carboxylic acid amides for treatment and prevention of diabetes typ 1 and 2
EP2462115B1 (de) 2009-08-05 2016-01-06 Infinity Pharmaceuticals, Inc. Enzymatische transaminierung von cyclopamin-analogen
US9394313B2 (en) 2010-09-14 2016-07-19 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds
AU2016271468B2 (en) 2015-06-04 2020-01-02 Sol-Gel Technologies Ltd. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766212A (en) * 1983-02-15 1988-08-23 Merrell Dow Pharmaceuticals Inc. 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives
AU597671B2 (en) * 1986-06-20 1990-06-07 Suntory Limited 2-Phenylbenzoxepin derivative

Also Published As

Publication number Publication date
JPH02243687A (ja) 1990-09-27
US5041444A (en) 1991-08-20
JP2851054B2 (ja) 1999-01-27
DK0388188T3 (da) 1994-02-14
EP0388188B1 (de) 1994-01-12
ATE100097T1 (de) 1994-01-15
DE69005861T2 (de) 1994-04-28
ES2062336T3 (es) 1994-12-16
EP0388188A1 (de) 1990-09-19

Similar Documents

Publication Publication Date Title
HU9401415D0 (en) Enzofuranyl- and -thiophenyl-alkane-carboxylic acid derivatives, pharmaceutical compositions contaning them, and process for producing them
EP0872481A4 (de) Depsipeptid-derivat, verfahren zu dessen herstellung und zwischenprodukt dafür
DE69637747D1 (de) Zuckerverbindungen
DE69005861D1 (de) Benzoxepin-Derivate.
AU8163091A (en) Novel tricyclic compound or salts thereof, method for producing the same and antimicrobial agent containing the same
AU5835190A (en) Antitumor substance be-13793c
AU5156593A (en) Vitamin d derivative and process for producing the same
ATE141583T1 (de) Alpha-methylencyclopentanon-derivate und verfahren zu ihrer herstellung
PL288792A1 (en) Method of obtaining novel compounds
NZ332245A (en) Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
EP1132375A4 (de) Derivate der aminoacryl-säure und ein verfahren zur herstellung derselben
EP0955376A4 (de) Antibiotikum TKR 459, Herstellungsverfahren und Mikroorganismus
ATE298744T1 (de) Amycomycin, verfahren zu dessen herstellung und seine verwendung als arzneimittel
CA2122705A1 (en) Optically Active 1-Phenylpyrrolidone Derivative, Intermediate for Producing the Same, and Process for Producing Both
AU7535287A (en) A method for epimerizing an optically active benzylalcohol derivative
DE69000335T2 (de) Butalactin, verfahren zu seiner herstellung und seine verwendung als arzneimittel.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee