ES2062206T3 - Composicion estabilizada de fgf y su produccion. - Google Patents
Composicion estabilizada de fgf y su produccion.Info
- Publication number
- ES2062206T3 ES2062206T3 ES90112850T ES90112850T ES2062206T3 ES 2062206 T3 ES2062206 T3 ES 2062206T3 ES 90112850 T ES90112850 T ES 90112850T ES 90112850 T ES90112850 T ES 90112850T ES 2062206 T3 ES2062206 T3 ES 2062206T3
- Authority
- ES
- Spain
- Prior art keywords
- fgf protein
- fgf
- production
- composition
- stabilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fodder In General (AREA)
Abstract
SE DESCUBREN (1) UNA COMPOSICION DE PROTEINA FGF ESTABILIZADA LA CUAL COMPRENDE UNA PROTEINA FGF E HIDROXIPROPILO DE CELULOSA INSOLUBLE EN AGUA; (2) UN METODO PARA PREPARAR UNA COMPOSICION PROTEICA FGF ESTABILIZADA, EL CUAL COMPRENDE MEZCLAR UNA PROTEINA FGF CON HIDROXIPROPILO DE CELULOSA INSOLUBLE EN AGUA; Y (3) UN METODO PARA ESTABILIZAR UNA PROTEINA FGF, EL CUAL COMPRENDE MEZCLAR UNA PROTEINA FGF CON UN HIDROXIPROPILO DE CELULOSA INSOLUBLE EN AGUA, MEDIANTE LO CUAL SE PUEDE PROVEER UNA PROTEINA FGF ESTABILIZADA. LA COMPOSICION SE OBTIENE EN UN ESTADO SOLIDO EL CUAL ESTA PROVISTO DE ESTABILIDAD.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17622889 | 1989-07-07 | ||
JP13633390 | 1990-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062206T3 true ES2062206T3 (es) | 1994-12-16 |
Family
ID=26469955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90112850T Expired - Lifetime ES2062206T3 (es) | 1989-07-07 | 1990-07-05 | Composicion estabilizada de fgf y su produccion. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5189148A (es) |
EP (1) | EP0406856B1 (es) |
JP (1) | JP2536247B2 (es) |
CN (1) | CN1049106A (es) |
AT (1) | ATE102044T1 (es) |
AU (1) | AU632344B2 (es) |
CA (1) | CA2020654A1 (es) |
DE (1) | DE69006947T2 (es) |
DK (1) | DK0406856T3 (es) |
ES (1) | ES2062206T3 (es) |
FI (1) | FI903440A0 (es) |
HU (1) | HU205862B (es) |
IE (1) | IE902470A1 (es) |
NO (1) | NO902995L (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5202311A (en) * | 1988-08-19 | 1993-04-13 | Children's Medical Center Corporation | Stabilized fgf composition |
US5714458A (en) * | 1990-07-18 | 1998-02-03 | Farmitalia Carlo Erba S.R.L. | Stable pharmaceutical compositions containing a fibroblast growth factor |
GB9015824D0 (en) * | 1990-07-18 | 1990-09-05 | Erba Carlo Spa | Stable pharmaceutical compositions containing a fibroblast growth factor |
US5500409A (en) * | 1990-10-01 | 1996-03-19 | Thomas Jefferson University | Method for inhibiting collagen synthesis by keloid fibroblasts |
TW209174B (es) * | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
ES2109362T3 (es) | 1991-06-21 | 1998-01-16 | Univ Cincinnati | Unas proteinas administrables oralmente y metodo para hacerlas. |
DE4121043A1 (de) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
CA2080537A1 (en) * | 1991-10-21 | 1993-04-22 | David B. Volkin | Stabilized topical acidic fibroblast growth factor formulation |
CA2080538A1 (en) * | 1991-10-21 | 1993-04-22 | Joseph V. Bondi | Lyophilized acidic fibroblast growth factor |
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5482929A (en) * | 1991-12-26 | 1996-01-09 | Kaken Pharmaceutical Co., Ltd. | Composition of stabilized fibroblast growth factor |
US7070806B2 (en) * | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5348941A (en) * | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
DE4242889A1 (de) * | 1992-12-18 | 1994-06-23 | Merck Patent Gmbh | Hohlendoprothesen mit Knochenwachstumsfördernder Füllung |
JP3349535B2 (ja) * | 1993-01-12 | 2002-11-25 | フロイント産業株式会社 | 球形顆粒の製造方法 |
US5331095A (en) * | 1993-04-12 | 1994-07-19 | Scios Nova Inc. | Process for purification of basic fibroblast growth factor |
WO1994027630A1 (fr) * | 1993-05-31 | 1994-12-08 | Kaken Pharmaceutical Co., Ltd. | Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base |
JPH07112940A (ja) * | 1993-08-26 | 1995-05-02 | Takeda Chem Ind Ltd | 徐放性非経口投与製剤およびその製造方法 |
EP0943336A1 (en) * | 1996-09-04 | 1999-09-22 | Dott Research Laboratory | Peptide-containing pharmaceutical compositions for oral administration |
US6692961B1 (en) * | 1996-10-11 | 2004-02-17 | Invitrogen Corporation | Defined systems for epithelial cell culture and use thereof |
US5851579A (en) * | 1996-10-28 | 1998-12-22 | Eastman Chemical Company | Aqueous enteric coating compositions |
EP1189523B1 (en) * | 1999-06-07 | 2003-06-25 | Fibersugar APS | Particulate fibre composition |
US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
MXPA02006324A (es) * | 1999-12-23 | 2002-12-13 | Pfizer Prod Inc | Composiciones farmaceuticas que proporcionan concentraciones potenciadas de farmaco. |
JP4711520B2 (ja) * | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
US9387094B2 (en) | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
US7323193B2 (en) | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
EP1434608B1 (en) | 2001-10-12 | 2018-08-22 | Warsaw Orthopedic, Inc. | Improved bone graft |
FR2836011B1 (fr) * | 2002-02-20 | 2004-05-14 | Goemar Lab Sa | Agent pour la stimulation des defenses naturelles des plantes et procede pour sa mise en oeuvre |
CA2481214A1 (en) * | 2002-04-01 | 2003-10-09 | Kaken Pharmaceutical Co., Ltd. | Viscous preparation for dental use containing basic fibroblast growth factor |
AU2004247143B2 (en) | 2003-06-11 | 2010-09-23 | Warsaw Orthopedic, Inc. | Osteoimplants and methods for their manufacture |
WO2005058207A1 (en) | 2003-12-11 | 2005-06-30 | Isto Technologies, Inc. | Particulate cartilage system |
US20070004036A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for keratinocyte culture |
US20070128685A1 (en) * | 2005-07-01 | 2007-06-07 | Rodolfo Faudoa | Methods and compositions for cell culture |
US20070003541A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for therapeutics |
WO2007025290A2 (en) | 2005-08-26 | 2007-03-01 | Isto Technologies, Inc. | Implants and methods for repair, replacement and treatment of joint disease |
WO2007056671A1 (en) | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
US20080154233A1 (en) * | 2006-12-20 | 2008-06-26 | Zimmer Orthobiologics, Inc. | Apparatus for delivering a biocompatible material to a surgical site and method of using same |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
US20090012629A1 (en) * | 2007-04-12 | 2009-01-08 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
KR20110086045A (ko) | 2008-10-24 | 2011-07-27 | 오스테오테크, 인코포레이티드 | 뼈 형성 촉진용 조성물 및 뼈 형성 촉진방법 |
EP2832848B1 (en) * | 2012-03-30 | 2019-02-13 | Ajinomoto Co., Inc. | Culture medium for proliferating stem cell, which contains sulfated compound |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US11746135B2 (en) | 2015-11-27 | 2023-09-05 | Masarykova Univerzita | Thermostable FGF2 polypeptide, use thereof |
JP2021138648A (ja) * | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
EP4183796A1 (en) | 2021-11-19 | 2023-05-24 | Enantis s.r.o. | Thermostable fgf10 polypeptide or fragment thereof use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4717717A (en) * | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
NZ235556A (en) * | 1986-11-05 | 1991-06-25 | Ethicon Inc | Breast milk substitute containing recombinant human egf |
JP2526965B2 (ja) * | 1987-02-24 | 1996-08-21 | 武田薬品工業株式会社 | ムテイン,dnaおよびその用途 |
NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
NZ226170A (en) * | 1987-09-18 | 1990-07-26 | Ethicon Inc | Stable freeze-dried pharmaceutical composition containing epidermal growth factor |
-
1990
- 1990-06-06 CA CA002020654A patent/CA2020654A1/en not_active Abandoned
- 1990-07-03 US US07/547,454 patent/US5189148A/en not_active Expired - Fee Related
- 1990-07-04 NO NO90902995A patent/NO902995L/no unknown
- 1990-07-05 JP JP2178917A patent/JP2536247B2/ja not_active Expired - Lifetime
- 1990-07-05 DE DE69006947T patent/DE69006947T2/de not_active Expired - Fee Related
- 1990-07-05 EP EP90112850A patent/EP0406856B1/en not_active Expired - Lifetime
- 1990-07-05 AT AT90112850T patent/ATE102044T1/de not_active IP Right Cessation
- 1990-07-05 ES ES90112850T patent/ES2062206T3/es not_active Expired - Lifetime
- 1990-07-05 DK DK90112850.4T patent/DK0406856T3/da active
- 1990-07-06 CN CN90103391A patent/CN1049106A/zh active Pending
- 1990-07-06 IE IE247090A patent/IE902470A1/en unknown
- 1990-07-06 AU AU58799/90A patent/AU632344B2/en not_active Ceased
- 1990-07-06 HU HU904116A patent/HU205862B/hu not_active IP Right Cessation
- 1990-07-06 FI FI903440A patent/FI903440A0/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU904116D0 (en) | 1990-12-28 |
DE69006947T2 (de) | 1994-08-25 |
AU632344B2 (en) | 1992-12-24 |
DK0406856T3 (da) | 1994-07-04 |
NO902995D0 (no) | 1990-07-04 |
HU205862B (en) | 1992-07-28 |
JP2536247B2 (ja) | 1996-09-18 |
IE902470A1 (en) | 1991-02-13 |
JPH04128239A (ja) | 1992-04-28 |
NO902995L (no) | 1991-01-08 |
HUT54895A (en) | 1991-04-29 |
ATE102044T1 (de) | 1994-03-15 |
CN1049106A (zh) | 1991-02-13 |
EP0406856A2 (en) | 1991-01-09 |
AU5879990A (en) | 1991-01-10 |
CA2020654A1 (en) | 1991-01-08 |
DE69006947D1 (de) | 1994-04-07 |
FI903440A0 (fi) | 1990-07-06 |
EP0406856A3 (en) | 1991-04-10 |
EP0406856B1 (en) | 1994-03-02 |
US5189148A (en) | 1993-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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