ES2062086T3 - Nuevos derivados de leucotrieno-b4, procedimientos para su preparacion y su utilizacion como medicamentos. - Google Patents
Nuevos derivados de leucotrieno-b4, procedimientos para su preparacion y su utilizacion como medicamentos.Info
- Publication number
- ES2062086T3 ES2062086T3 ES89730124T ES89730124T ES2062086T3 ES 2062086 T3 ES2062086 T3 ES 2062086T3 ES 89730124 T ES89730124 T ES 89730124T ES 89730124 T ES89730124 T ES 89730124T ES 2062086 T3 ES2062086 T3 ES 2062086T3
- Authority
- ES
- Spain
- Prior art keywords
- residue
- group
- hydrogen atom
- derivates
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE PATENTE ABARCA DERIVADOS DE LEUCOTRIENO-B4 DE FORMULA I, DONDE R1 REPRESENTA EL RESTO CH2OH, EL RESTO COOR5 O EL RESTO CONHR6; A ES UN GRUPO TRANS,TRANS - CH = CH - CH = CH O TETRAMETILENO, B ES UN GRUPO ALQUILENO CON HASTA 10 ATOMOS DE CARBONO, DE CADENA SIMPLE O COMPLEJA, SATURADO O NO; D ES UN ENLACE DIRECTO, OXIGENO, AZUFRE, UN GRUPO - C (EQUIVALE) C - O UN GRUPO CH = CR7, B Y D JUNTOS SON UN ENLACE DIRECTO; R2 Y R3 PUEDEN SER IGUALES O DISTINTOS, Y REPRESENTAN UN ATOMO DE HIDROGENO O UN RESTO ACIDO DE UN ACIDO ORGANICO CON 1-15 ATOMOS DE CARBONO; Y R4 ES UN ATOMO DE HIDROGENO, UN RESTO ALQUILO, UN RESTO CICLOALQUILO, UN RESTO ARILO O UN RESTO HETEROCICLICO DE 5 O 6 MIEMBROS EN EL CASO DE QUE R5 SEA UN ATOMO DE HIDROGENO. TAMBIEN ABARCA LAS SALES DE ESTOS COMPUESTOS CON BASES FISIOLOGICAMENTE COMPATIBLES Y SUS CICLODEXTRINCLATRATOS, TAMBIEN EL PROCESO PARA SU OBTENCION Y SU USO COMO MEDICAMENTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3817385A DE3817385A1 (de) | 1988-05-19 | 1988-05-19 | Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062086T3 true ES2062086T3 (es) | 1994-12-16 |
Family
ID=6354874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89730124T Expired - Lifetime ES2062086T3 (es) | 1988-05-19 | 1989-05-19 | Nuevos derivados de leucotrieno-b4, procedimientos para su preparacion y su utilizacion como medicamentos. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0344096B1 (es) |
JP (1) | JPH03505326A (es) |
AT (1) | ATE99663T1 (es) |
AU (1) | AU3733489A (es) |
DE (2) | DE3817385A1 (es) |
DK (1) | DK275390A (es) |
ES (1) | ES2062086T3 (es) |
HU (1) | HUT54605A (es) |
IE (1) | IE66678B1 (es) |
IL (1) | IL90351A0 (es) |
WO (1) | WO1989011469A1 (es) |
ZA (1) | ZA893795B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988005045A1 (en) * | 1986-12-29 | 1988-07-14 | The Upjohn Company | Leukotriene b4 analogs |
DE4009117A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US6342525B1 (en) * | 1999-11-09 | 2002-01-29 | Alcon Universal Ltd. | Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders |
JP4807549B2 (ja) * | 2003-02-28 | 2011-11-02 | 克彦 友岡 | シロキサン類,シラノール類及びシラン類,並びにその製造方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0296580B1 (en) * | 1987-06-26 | 1992-11-11 | G.D. Searle & Co. | Phenylene, furyl, and thienyl leukotriene b4 analogues |
US4855324A (en) * | 1987-12-08 | 1989-08-08 | G. D. Searle & Co. | Furyl, phenylene, and thienyl leukotriene B4 analogues |
-
1988
- 1988-05-19 DE DE3817385A patent/DE3817385A1/de not_active Withdrawn
-
1989
- 1989-05-19 AU AU37334/89A patent/AU3733489A/en not_active Abandoned
- 1989-05-19 AT AT89730124T patent/ATE99663T1/de not_active IP Right Cessation
- 1989-05-19 HU HU893626A patent/HUT54605A/hu unknown
- 1989-05-19 ZA ZA893795A patent/ZA893795B/xx unknown
- 1989-05-19 JP JP1505373A patent/JPH03505326A/ja active Pending
- 1989-05-19 WO PCT/DE1989/000326 patent/WO1989011469A1/de active Application Filing
- 1989-05-19 DE DE89730124T patent/DE58906619D1/de not_active Expired - Fee Related
- 1989-05-19 IE IE162689A patent/IE66678B1/en not_active IP Right Cessation
- 1989-05-19 ES ES89730124T patent/ES2062086T3/es not_active Expired - Lifetime
- 1989-05-19 EP EP89730124A patent/EP0344096B1/de not_active Expired - Lifetime
- 1989-05-19 IL IL90351A patent/IL90351A0/xx unknown
-
1990
- 1990-11-19 DK DK275390A patent/DK275390A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1989011469A1 (en) | 1989-11-30 |
IE66678B1 (en) | 1996-01-24 |
IL90351A0 (en) | 1989-12-15 |
HU893626D0 (en) | 1991-01-28 |
IE891626L (en) | 1989-11-19 |
EP0344096B1 (de) | 1994-01-05 |
DK275390D0 (da) | 1990-11-19 |
AU3733489A (en) | 1989-12-12 |
JPH03505326A (ja) | 1991-11-21 |
HUT54605A (en) | 1991-03-28 |
DE3817385A1 (de) | 1989-11-30 |
ZA893795B (en) | 1990-11-28 |
DK275390A (da) | 1990-11-19 |
DE58906619D1 (de) | 1994-02-17 |
ATE99663T1 (de) | 1994-01-15 |
EP0344096A1 (de) | 1989-11-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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