ZA893795B - New leukotriene b4 derivatives,a process for their producation and their use as pharmaceutical agents - Google Patents

New leukotriene b4 derivatives,a process for their producation and their use as pharmaceutical agents

Info

Publication number
ZA893795B
ZA893795B ZA893795A ZA893795A ZA893795B ZA 893795 B ZA893795 B ZA 893795B ZA 893795 A ZA893795 A ZA 893795A ZA 893795 A ZA893795 A ZA 893795A ZA 893795 B ZA893795 B ZA 893795B
Authority
ZA
South Africa
Prior art keywords
residue
group
hydrogen atom
producation
derivatives
Prior art date
Application number
ZA893795A
Inventor
Werner Skuballa
Skuballa Werner
Bernd Buchmann
Buchmann Bernd
Wolfgang Froehlich
Froehlich Wolfgang
Roland Ekerdt
Ekerdt Roland
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA893795B publication Critical patent/ZA893795B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
    • C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Leukotriene-B4 derivates are disclosed having the formula (I), in which R1 is the residue CH2OH, the residue COOR5 or the residue CONHR6, A is a transmethylene group, a trans-CH=CH-CH=CH-methylene group or a tetramethylene group, B is a straight or branched chain, saturated or insaturated alkylene group with up to 10 C-atoms, D is a direct link, oxygen, sulfur, a -C=C- group or a -CH=CR7- group, B and D form together a direct link, R2 and R3 can be identical or different, and represent a hydrogen atom or an acid residue of an organic acid with 1 to 15 C-atoms and R4 is a hydrogen atom, an alkyl residue, a cycloalkyl residue, an aryl residue or a heterocyclic residue with 5 to 6 members and, when R5 is a hydrogen atom, their salts with physiologically compatible bases and their cyclodextrinclathrates. A process for producing these derivates and their use as medicaments are also disclosed.
ZA893795A 1988-05-19 1989-05-19 New leukotriene b4 derivatives,a process for their producation and their use as pharmaceutical agents ZA893795B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3817385A DE3817385A1 (en) 1988-05-19 1988-05-19 NEW LEUKOTRIA-B (DOWN ARROW) 4 (DOWN ARROW) DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ZA893795B true ZA893795B (en) 1990-11-28

Family

ID=6354874

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893795A ZA893795B (en) 1988-05-19 1989-05-19 New leukotriene b4 derivatives,a process for their producation and their use as pharmaceutical agents

Country Status (12)

Country Link
EP (1) EP0344096B1 (en)
JP (1) JPH03505326A (en)
AT (1) ATE99663T1 (en)
AU (1) AU3733489A (en)
DE (2) DE3817385A1 (en)
DK (1) DK275390A (en)
ES (1) ES2062086T3 (en)
HU (1) HUT54605A (en)
IE (1) IE66678B1 (en)
IL (1) IL90351A0 (en)
WO (1) WO1989011469A1 (en)
ZA (1) ZA893795B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339046B1 (en) * 1986-12-29 1995-02-15 The Upjohn Company Leukotriene b 4 analogs
DE4009117A1 (en) * 1990-03-19 1991-09-26 Schering Ag NEW LEUKOTRIA-B (DOWN ARROW) 4 (DOWN ARROW) DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
CA2388030A1 (en) * 1999-11-09 2001-05-17 Alcon, Inc. Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders
JP4807549B2 (en) * 2003-02-28 2011-11-02 克彦 友岡 Siloxanes, silanols and silanes, and methods for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052639T3 (en) * 1987-06-26 1994-07-16 Searle & Co ANALOGS OF FENILEN-, FURIL- AND TIENIL-LEUCOTRENE B4.
US4855324A (en) * 1987-12-08 1989-08-08 G. D. Searle & Co. Furyl, phenylene, and thienyl leukotriene B4 analogues

Also Published As

Publication number Publication date
IE66678B1 (en) 1996-01-24
DK275390D0 (en) 1990-11-19
IE891626L (en) 1989-11-19
ES2062086T3 (en) 1994-12-16
JPH03505326A (en) 1991-11-21
AU3733489A (en) 1989-12-12
DE58906619D1 (en) 1994-02-17
IL90351A0 (en) 1989-12-15
EP0344096A1 (en) 1989-11-29
HUT54605A (en) 1991-03-28
DK275390A (en) 1990-11-19
WO1989011469A1 (en) 1989-11-30
EP0344096B1 (en) 1994-01-05
ATE99663T1 (en) 1994-01-15
HU893626D0 (en) 1991-01-28
DE3817385A1 (en) 1989-11-30

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