ES2060803T3 - Soporte biologico para cultivos celulares constituido por proteinas plasmaticas coaguladas por trombina, su utilizacion para el cultivo de los queratinocitos, su recuperacion y su transporte con fines de utilizacion terapeutica. - Google Patents

Soporte biologico para cultivos celulares constituido por proteinas plasmaticas coaguladas por trombina, su utilizacion para el cultivo de los queratinocitos, su recuperacion y su transporte con fines de utilizacion terapeutica.

Info

Publication number
ES2060803T3
ES2060803T3 ES89403319T ES89403319T ES2060803T3 ES 2060803 T3 ES2060803 T3 ES 2060803T3 ES 89403319 T ES89403319 T ES 89403319T ES 89403319 T ES89403319 T ES 89403319T ES 2060803 T3 ES2060803 T3 ES 2060803T3
Authority
ES
Spain
Prior art keywords
keratinocits
cultivation
recovery
transport
cell cultures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89403319T
Other languages
English (en)
Other versions
ES2060803T5 (es
Inventor
Herve Broly
Vincent Ronfard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRE REGIONAL DE TRANSFUSION
Centre Regional de Transfusion Sanguine de Lille
Original Assignee
CENTRE REGIONAL DE TRANSFUSION
Centre Regional de Transfusion Sanguine de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9372604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2060803(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by CENTRE REGIONAL DE TRANSFUSION, Centre Regional de Transfusion Sanguine de Lille filed Critical CENTRE REGIONAL DE TRANSFUSION
Application granted granted Critical
Publication of ES2060803T3 publication Critical patent/ES2060803T3/es
Publication of ES2060803T5 publication Critical patent/ES2060803T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/56—Fibrin; Thrombin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SOPORTE BIOLOGICO PARA CULTIVOS CELULARES CONSTITUIDO POR LA MEZCLA COAGULADA DE UN CONCENTRADO DE PROTEINAS PLASMATICAS Y TROMBINA. EL CONCENTRADO DE PROTEINAS SE OBTIENE POR PRECIPITACION DE PLASMA FRESCO EN ETANOL, Y CONTIENE PROPORCIONES EQUILIBRADAS DE FIBRINOGENO, FACTOR XIII Y FIBRONECTINA. LA CONCENTRACION EN TROMBINA SE AJUSTA PARA CONSEGUIR LA CONSISTENCIA DESEADA DEL SOPORTE COAGULADO BAJO FORMA DE PELICULA. EL SOPORTE BIOLOGICO SE UTILIZA PREFERIBLEMENTE PARA EL CULTIVO DE QUERATINOCITOS, SU RECUPERACION BAJO FORMA DE TEJIDO RECONSTITUIDO Y EL TRANSPORTE DE ESTE. EL TEJIDO RECONSTITUIDO SE ADAPTA ASI ESPECIALMENTE PARA EL USO COMO INJERTO.
ES89403319T 1988-12-06 1989-11-30 Soporte biologico para cultivos celulares constituido por proteinas plasmaticas coaguladas por trombina, su utilizacion para el cultivo de los queratinocitos, su recuperacion y su transporte con fines de utilizacion terapeutica. Expired - Lifetime ES2060803T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8815950 1988-12-06
FR8815950A FR2639958B1 (fr) 1988-12-06 1988-12-06 Support biologique pour cultures cellulaires constitue de proteines plasmatiques coagulees par la thrombine, son utilisation pour la culture des keratinocytes, leur recuperation et leur transport a des fins d'utilisation therapeutique

Publications (2)

Publication Number Publication Date
ES2060803T3 true ES2060803T3 (es) 1994-12-01
ES2060803T5 ES2060803T5 (es) 2004-06-16

Family

ID=9372604

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89403319T Expired - Lifetime ES2060803T5 (es) 1988-12-06 1989-11-30 Soporte biologico para cultivos celulares constituido por proteinas plasmaticas coaguladas por trombina, su utilizacion para el cultivo de los queratinocitos, su recuperacion y su transporte con fines de utilizacion terapeutica.

Country Status (6)

Country Link
US (1) US5474770A (es)
EP (1) EP0373044B2 (es)
AT (1) ATE113071T1 (es)
DE (1) DE68918922T3 (es)
ES (1) ES2060803T5 (es)
FR (1) FR2639958B1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2165678A1 (en) 2001-03-01 2010-03-24 Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas (C.I.E.M.A.T.) Artificial dermis and production method therefor
WO2015119491A1 (es) * 2014-02-04 2015-08-13 Alvaro Galue Eduardo Proceso de obtencion de un compuesto de aspersion celular de fibroblastos y queratinocitos humanos en solucion y su uso como agente regenerativo de lesiones cutáneas

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
FR2743421B1 (fr) * 1996-01-08 1998-03-20 Aetsrn Procede pour l'evaluation de la migration des keratinocytes
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
US6110895A (en) * 1996-12-16 2000-08-29 University Of Southern California Method of promoting healing in skin grafts
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
DE19851334C2 (de) * 1998-11-06 2000-09-28 Aventis Behring Gmbh Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung
AU764347B2 (en) * 1998-12-02 2003-08-14 Vivolution A/S Spray delivery of cells
DK1151007T3 (da) 1999-02-12 2006-09-04 Baxter Ag Fremgangsmåde til fremstilling af et præparat baseret på fibrinogen og fibronectin samt proteinsammensætninger fremstillet derved
JP4771594B2 (ja) * 1999-02-12 2011-09-14 バクスター アクチェンゲゼルシャフト フィブリノーゲンおよびフィブロネクチンをベースとする製剤を生成するための方法ならびにこの方法により入手可能なタンパク質組成物
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US6371984B1 (en) 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
DE19958693C2 (de) * 1999-12-06 2002-07-18 Biotissue Technologies Gmbh Verfahren und Zusammensetzungen zur Herstellung von Zelltransplantaten
US7144729B2 (en) 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
US20040126881A1 (en) * 2002-09-06 2004-07-01 Vincent Ronfard Fibrin cell supports and methods of use thereof
FR2904223B1 (fr) * 2006-07-26 2013-01-11 Oreal Utilisation de carboxypeptidases dans le domaine cosmetique et therapeutique
WO2008012476A2 (fr) * 2006-07-26 2008-01-31 L'oreal Utilisation de carboxypeptidases dans le domaine cosmetique et therapeutique
WO2010132673A1 (en) 2009-05-13 2010-11-18 Keraplast Technologies, Ltd. Biopolymer materials
US9962480B2 (en) 2012-01-23 2018-05-08 Estar Technologies Ltd System and method for obtaining a cellular sample enriched with defined cells such as platelet rich plasma (PRP)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2469193A (en) * 1942-02-09 1949-05-03 Research Corp Protein fractionation
US2533004A (en) * 1943-10-27 1950-12-05 John D Ferry Fibrin clots and methods for preparing the same
US3920625A (en) * 1973-06-19 1975-11-18 Kabi Ab Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates
AT359652B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
ATE20824T1 (de) * 1981-06-25 1986-08-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung.
US4442655A (en) * 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
US4452893A (en) * 1981-08-03 1984-06-05 Cutter Laboratories, Inc. Cell growth medium supplement
DE3203775A1 (de) * 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
GB8331803D0 (en) * 1983-11-29 1984-01-04 Macleod A J Preparing component of cell growth medium
US5260420A (en) * 1987-07-30 1993-11-09 Centre Regional De Transfusion Sanguine De Lille Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof
FR2618784B1 (fr) * 1987-07-30 1990-04-06 Lille Transfusion Sanguine Concentre de proteines coagulables par la thrombine, son procede d'obtention et son utilisation a titre de colle biologique

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2165678A1 (en) 2001-03-01 2010-03-24 Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas (C.I.E.M.A.T.) Artificial dermis and production method therefor
WO2015119491A1 (es) * 2014-02-04 2015-08-13 Alvaro Galue Eduardo Proceso de obtencion de un compuesto de aspersion celular de fibroblastos y queratinocitos humanos en solucion y su uso como agente regenerativo de lesiones cutáneas

Also Published As

Publication number Publication date
DE68918922T2 (de) 1995-04-20
FR2639958A1 (fr) 1990-06-08
DE68918922D1 (de) 1994-11-24
US5474770A (en) 1995-12-12
ATE113071T1 (de) 1994-11-15
EP0373044A1 (fr) 1990-06-13
FR2639958B1 (fr) 1992-08-21
EP0373044B2 (fr) 2003-09-03
ES2060803T5 (es) 2004-06-16
EP0373044B1 (fr) 1994-10-19
DE68918922T3 (de) 2004-11-11

Similar Documents

Publication Publication Date Title
ES2060803T3 (es) Soporte biologico para cultivos celulares constituido por proteinas plasmaticas coaguladas por trombina, su utilizacion para el cultivo de los queratinocitos, su recuperacion y su transporte con fines de utilizacion terapeutica.
Shadduck et al. Production of colony stimulating factor in long‐term bone marrow cultures
Terranova et al. Human endothelial cells are chemotactic to endothelial cell growth factor and heparin.
Younai et al. Modulation of collagen synthesis by transforming growth factor-β in keloid and hypertrophic scar fibroblasts
IL150018A0 (en) Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
Sampath et al. Extracellular bone matrix-derived growth factor
Poole et al. Stimulation of rat peritoneal mast cell migration by tumor-derived peptides
NO940597L (no) Isolering, vekst, differensiering og genslöyd på menneskers muskelceller
ATE110108T1 (de) Genetische modifizierung von endothelialen zellen.
IL139699A0 (en) Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
EA200201008A1 (ru) Получение рекомбинантных факторов свертывания крови в линиях клеток человека
NO960111L (no) Preparater og metoder for stimulering av vekst og differensiering av megakaryocytter
DE3855523D1 (de) Proteine mit Faktor-VIII-Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende pharmazeutische Zusammensetzungen
ATE438386T1 (de) Teilchenförmige zellfreie gewebematrix
DE68914582D1 (de) Endothelin-DNA und ihre Verwendung.
ES536510A0 (es) Un procedimiento para preparar un extracto completo de organos de mamiferos y de cultivos celulares
DE69939330D1 (de) Wachstumsfaktor-homologe zvegf-3
TAYLOR-PAPADIMITRIOU et al. Inhibitory effect of interferon on cellular DNA synthesis: modulation by pure mitogenic factors
ATE107665T1 (de) Proteaseresistenter pdgf und dessen verwendungen.
DE602005016847D1 (de) Nichtaktivierte polypeptide mit einer geweberegenerationsfunktion und verfahren zu ihrer herstellung
BR0312365A (pt) Meio de cultura autólogo de células-mães progenitoras autólogas humanas, métodos para a preparação do mesmo e de uma composição de células-mães progenitoras autólogas humanas e para a obtenção de células-mães progenitoras musculares autólogas humanas, emprego de um meio de cultura autólogo de células-mães progenitoras autólogas humanas, procedimento para a obtenção de células-mães progenitoras musculares autólogas humanas e procedimento terapêutico de cardiomioplastia celular autóloga, composição enriquecida com células-mães progenitoras musculares autólogas humanas e composição farmacêutica
CN101875699A (zh) 人表皮生长因子和金属硫蛋白的融合蛋白及其制备方法和应用
Porter et al. The culture of tissue cells in clots formed from purified bovine fibrinogen and thrombin.
Fojo et al. The isolation and characterization of a colony stimulating factor from human lung
Falanga et al. The effects of endothelin-1 on human dermal fibroblast growth and synthetic activity

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 373044

Country of ref document: ES