ES2060715T3 - Medicamentos escasamente solubles inmovilizados en substancias polimericas de una manera adecuada para incrementar su grado de disolucion. - Google Patents
Medicamentos escasamente solubles inmovilizados en substancias polimericas de una manera adecuada para incrementar su grado de disolucion.Info
- Publication number
- ES2060715T3 ES2060715T3 ES89119241T ES89119241T ES2060715T3 ES 2060715 T3 ES2060715 T3 ES 2060715T3 ES 89119241 T ES89119241 T ES 89119241T ES 89119241 T ES89119241 T ES 89119241T ES 2060715 T3 ES2060715 T3 ES 2060715T3
- Authority
- ES
- Spain
- Prior art keywords
- dissolution
- scarly
- immobilized
- degree
- increase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004090 dissolution Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- 229920006037 cross link polymer Polymers 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
DICHO MEDICAMENTO ES INCORPORADO A PARTICULAS DE UN POLIMERO LIGADO EN CRUZ, EL CUAL ES DILATABLE EN AGUA PERO NO SOLUBLE, Y EL PRODUCTO OBTENIDO ES LLEVADO A CONTACTAR CON UN DISOLVENTE CAPAZ DE DILATAR EL POLIMERO. EL PRODUCTO OBTENIDO POR ESTE TRATAMIENTO ES DESPUES SECADO AL VACIO Y TIENE UN PORCENTAJE DE DISOLUCION CONSIDERABLEMENTE MAYOR QUE EL MEDICAMENTO PURO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8822336A IT1230566B (it) | 1988-10-17 | 1988-10-17 | Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2060715T3 true ES2060715T3 (es) | 1994-12-01 |
Family
ID=11194858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89119241T Expired - Lifetime ES2060715T3 (es) | 1988-10-17 | 1989-10-17 | Medicamentos escasamente solubles inmovilizados en substancias polimericas de una manera adecuada para incrementar su grado de disolucion. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0364944B1 (es) |
JP (1) | JP2869103B2 (es) |
KR (1) | KR0148006B1 (es) |
AT (1) | ATE91622T1 (es) |
CA (1) | CA2000744C (es) |
DE (1) | DE68907687T2 (es) |
ES (1) | ES2060715T3 (es) |
HU (1) | HU203481B (es) |
IT (1) | IT1230566B (es) |
YU (1) | YU198489A (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1243745B (it) * | 1990-10-17 | 1994-06-21 | Vectorpharma Int | Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione. |
EP1004318A3 (en) * | 1991-06-21 | 2002-08-07 | Takeda Chemical Industries, Ltd. | Cyclodextrin composition |
IT1252867B (it) * | 1991-12-31 | 1995-06-28 | Gentili Ist Spa | Composizioni farmaceutiche contenenti progesterone ad elevata biodisponibilita' |
AU722246B2 (en) * | 1995-06-07 | 2000-07-27 | Johnson & Johnson Consumer Products, Inc. | Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same |
NL1003503C2 (nl) * | 1996-07-04 | 1998-01-07 | Negma Steba International Dev | Farmaceutische samenstelling voor orale toediening. |
US6287693B1 (en) | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
CA2353552A1 (en) * | 1998-12-04 | 2000-06-15 | California Institute Of Technology | Supramolecular complexes containing therapeutic agents |
IT1318404B1 (it) * | 2000-03-17 | 2003-08-25 | Eurand Int | Processo per la preparazione di formulazioni a rilascio accelerato conimpiego di fluidi compressi. |
PT1534340E (pt) | 2002-09-06 | 2012-03-13 | Cerulean Pharma Inc | Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente |
EP1844765B1 (en) | 2003-06-13 | 2015-01-21 | Skendi Finance, Ltd. | Slow release estradiol-progesterone formulation |
DE102006026578B4 (de) | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
WO2009034558A2 (en) | 2007-09-14 | 2009-03-19 | Wockhardt Research Centre | Rhein or diacerein compositions |
GB0812742D0 (en) | 2008-07-11 | 2008-08-20 | Critical Pharmaceuticals Ltd | Process |
TWI473610B (zh) * | 2008-10-28 | 2015-02-21 | Twi Biotechnology Inc | 包含雙醋瑞因(diacerein)之醫藥組合物 |
IE20100799A1 (en) | 2010-12-22 | 2012-08-01 | Eurand Pharmaceuticals Ltd | Pharmaceutical composites of poorly water soluble drugs and polymers |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU189534B (en) | 1981-09-09 | 1986-07-28 | Chinoin Rt.,Hu | Process for producing new tablets containing cyclodextrin polymer as desintegrator |
DE3326167A1 (de) * | 1983-07-20 | 1985-02-21 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Feste arzneiformen, die als wirkstoff n-4-(2-(5-chlor-2-methoxybenzamido)-ethyl)-phenylsulfonyl-n'-cyclohexylharnstoff enthalten und verfahren zu ihrer herstellung |
IE63321B1 (en) * | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
-
1988
- 1988-10-17 IT IT8822336A patent/IT1230566B/it active
-
1989
- 1989-10-13 YU YU01984/89A patent/YU198489A/xx unknown
- 1989-10-16 HU HU895330A patent/HU203481B/hu unknown
- 1989-10-16 KR KR1019890014823A patent/KR0148006B1/ko not_active IP Right Cessation
- 1989-10-16 CA CA002000744A patent/CA2000744C/en not_active Expired - Lifetime
- 1989-10-17 ES ES89119241T patent/ES2060715T3/es not_active Expired - Lifetime
- 1989-10-17 AT AT89119241T patent/ATE91622T1/de not_active IP Right Cessation
- 1989-10-17 JP JP1270148A patent/JP2869103B2/ja not_active Expired - Lifetime
- 1989-10-17 EP EP89119241A patent/EP0364944B1/en not_active Expired - Lifetime
- 1989-10-17 DE DE89119241T patent/DE68907687T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE91622T1 (de) | 1993-08-15 |
YU198489A (en) | 1991-08-31 |
EP0364944B1 (en) | 1993-07-21 |
HUT52398A (en) | 1990-07-28 |
DE68907687T2 (de) | 1993-10-28 |
CA2000744A1 (en) | 1990-04-17 |
HU895330D0 (en) | 1990-01-28 |
KR0148006B1 (ko) | 1998-08-17 |
DE68907687D1 (de) | 1993-08-26 |
CA2000744C (en) | 1999-12-07 |
IT8822336A0 (it) | 1988-10-17 |
IT1230566B (it) | 1991-10-28 |
KR900005960A (ko) | 1990-05-07 |
JP2869103B2 (ja) | 1999-03-10 |
EP0364944A1 (en) | 1990-04-25 |
HU203481B (en) | 1991-08-28 |
JPH02149513A (ja) | 1990-06-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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