ES2060146T3 - Metaloproteinasas colagenoliticas asociadas con metastasis. - Google Patents
Metaloproteinasas colagenoliticas asociadas con metastasis.Info
- Publication number
- ES2060146T3 ES2060146T3 ES90903555T ES90903555T ES2060146T3 ES 2060146 T3 ES2060146 T3 ES 2060146T3 ES 90903555 T ES90903555 T ES 90903555T ES 90903555 T ES90903555 T ES 90903555T ES 2060146 T3 ES2060146 T3 ES 2060146T3
- Authority
- ES
- Spain
- Prior art keywords
- enzyme
- disclosed
- found
- methods
- rat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE REVELAN METODOS Y COMPOSICIONES PARA TESTAR VARIOS TIPOS DE CANCERES HUMANOS, INCLUYENDO EN PARTICULAR CARCINOMA METASTATICO MAMARIO, ASTRACITOMA COLON CARCINOMA, CARCINOMA DE CELULA RENAL, Y MELANOMA TERATOCARCINOMA MALIGNO. EL METODO DE DIAGNOSTICO DE LA INVENCION COMPRENDE LA DETECCION DE METALOPROTEINAS GELATINOLITICAS Y COLAGENOLITICAS TIPO IV TENIENDO UN PESO MOLECULAR DE APROXIMADAMENTE DE 88 A 92 KILODALTONS. ESTE ALTO PESO MOLECULAR DE LA ENZIMA COLAGENOLITICA TIPO IV SE OBSERVA ESTA ASOCIADO CON EL ESTADO CANCEROSO, PUES NO SE OBSERVA EN NINGUNA DE LAS CELULAS NO CANCEROSAS TESTADAS Y ADEMAS TAMPOCO SE HA VISTO EN EL SUERO DE LOS ANIMALES PORTADORES SIN TUMOR. LA ENZIMA ESTA ASOCIADA CON TUMORES DE RATA Y HUMANO, SIENDO LA ENZIMA EN AMBOS CASOS BASTANTE SIMILAR. SE REVELAN METODOS PARA EL AISLAMIENTO DE LA ENZIMA 88/92 KD, SIENDO LA ENZIMA AISLADA UTIL PARA SU USO COMO ENZIMA CONTROL Y ANALISIS DIAGNOSTICOS. ADEMAS, LA ENZIMA AISLADA ES UTIL PARA LA PREPARACION DE ANTICUERPOS,INCLUYENDO ANTICUERPOS MONOCLONALES, TENIENDO ESPECIFICIDAD PARA LA ENZIMA ASOCIADA A METASTASIS. TAMBIEN SE REVELAN TECNICAS PARA EL AISLAMIENTO Y PURIFICACION PARCIAL DE LA ENZIMA A PARTIR DE RATA Y HUMANOS. ADEMAS SE REVELAN METODOS PARA LLEVAR A CABO PRUEBAS ENZIMATICAS E INMUNOLOGICAS PARA EL DIAGNOSTICO DE ENFERMEDADES METASTATICAS Y RECURRENTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31626089A | 1989-02-27 | 1989-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2060146T3 true ES2060146T3 (es) | 1994-11-16 |
Family
ID=23228283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90903555T Expired - Lifetime ES2060146T3 (es) | 1989-02-27 | 1990-01-29 | Metaloproteinasas colagenoliticas asociadas con metastasis. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0460016B1 (es) |
JP (1) | JPH04505699A (es) |
AT (1) | ATE98685T1 (es) |
AU (1) | AU639906B2 (es) |
CA (1) | CA2048695A1 (es) |
DE (1) | DE69005297T2 (es) |
DK (1) | DK0460016T3 (es) |
ES (1) | ES2060146T3 (es) |
WO (1) | WO1990010062A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324634A (en) * | 1992-03-31 | 1994-06-28 | The Research Foundation Of State University Of New York | Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer |
WO1994005807A1 (en) * | 1992-08-28 | 1994-03-17 | Dickson Robert B | Matrix-degrading metalloproteinase |
WO1997009420A2 (en) * | 1995-09-05 | 1997-03-13 | Celltech Therapeutics Limited | Dna sequences coding for a human metalloproteinase and variants thereof |
US7041787B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases |
US20130217034A1 (en) | 2010-08-13 | 2013-08-22 | Dentognostics Gmbh | Process for avoiding false positive results in a detecting process of an inflammation indicator in a rinse solution for taking up gingival crevicular fluid |
-
1990
- 1990-01-29 CA CA002048695A patent/CA2048695A1/en not_active Abandoned
- 1990-01-29 DE DE90903555T patent/DE69005297T2/de not_active Expired - Fee Related
- 1990-01-29 AU AU51047/90A patent/AU639906B2/en not_active Ceased
- 1990-01-29 JP JP2503713A patent/JPH04505699A/ja active Pending
- 1990-01-29 DK DK90903555.2T patent/DK0460016T3/da active
- 1990-01-29 AT AT90903555T patent/ATE98685T1/de active
- 1990-01-29 EP EP90903555A patent/EP0460016B1/en not_active Expired - Lifetime
- 1990-01-29 ES ES90903555T patent/ES2060146T3/es not_active Expired - Lifetime
- 1990-01-29 WO PCT/US1990/000506 patent/WO1990010062A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69005297D1 (de) | 1994-01-27 |
DE69005297T2 (de) | 1994-04-21 |
WO1990010062A1 (en) | 1990-09-07 |
AU5104790A (en) | 1990-09-26 |
ATE98685T1 (de) | 1994-01-15 |
DK0460016T3 (da) | 1994-04-25 |
EP0460016B1 (en) | 1993-12-15 |
AU639906B2 (en) | 1993-08-12 |
EP0460016A1 (en) | 1991-12-11 |
JPH04505699A (ja) | 1992-10-08 |
CA2048695A1 (en) | 1990-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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