ES2059717T3 - Nuevos polipeptidos y adn codante para estos. - Google Patents

Nuevos polipeptidos y adn codante para estos.

Info

Publication number
ES2059717T3
ES2059717T3 ES89301007T ES89301007T ES2059717T3 ES 2059717 T3 ES2059717 T3 ES 2059717T3 ES 89301007 T ES89301007 T ES 89301007T ES 89301007 T ES89301007 T ES 89301007T ES 2059717 T3 ES2059717 T3 ES 2059717T3
Authority
ES
Spain
Prior art keywords
amino acid
polypeptides
acid residue
dna code
new polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89301007T
Other languages
English (en)
Inventor
Michiko Yamayoshi
Hitoshi Kawashima
Junichi Yamagishi
Hirotada Kotani
Ryuji Furuta
Toshikazu Fukui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2059717T3 publication Critical patent/ES2059717T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NUEVOS POLIPEPTIDOS TIENEN UNA SECUENCIA MODIFICADA DE AMINOACIDOS DE POLIPEPTIDOS INTERLEUQUINA HUMANA 1 (TIPO - ALFA Y TIPO - BETA, EN QUE DICHA SECUENCIA DE AMINOACIDOS ES INTERCAMBIADA POR OTROS RESIDUOS DE AMINOACIDOS Y UN CIERTO RESIDUO DE AMINOACIDOS EN EL TERMINO N Y/O EN EL TERMONO C SON SUPRIMIDOS OPCIONALMENTE. LOS POLIPEPTIDOS NO TIENEN CAPACIDAD PARA INDUCIR PRODUCCION DE PROSTAGLANDINA E2 PERO MANTIENEN OTRAS ACTIVIDADES BIOLOGICAS DE INTERLEUQUINA HUMANA 1 TAL COMO ACTIVACION DE LINFOCITO. SE CREE QUE SON UTILES COMO MEDICAMENTOS.
ES89301007T 1988-02-03 1989-02-02 Nuevos polipeptidos y adn codante para estos. Expired - Lifetime ES2059717T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63024613A JP2698976B2 (ja) 1988-02-03 1988-02-03 新規ポリペプチド及びそれをコードするｄｎａ

Publications (1)

Publication Number Publication Date
ES2059717T3 true ES2059717T3 (es) 1994-11-16

Family

ID=12142999

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89301007T Expired - Lifetime ES2059717T3 (es) 1988-02-03 1989-02-02 Nuevos polipeptidos y adn codante para estos.

Country Status (6)

Country Link
EP (1) EP0327360B1 (es)
JP (1) JP2698976B2 (es)
KR (1) KR960016705B1 (es)
AT (1) ATE108207T1 (es)
DE (1) DE68916559T2 (es)
ES (1) ES2059717T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2667601A1 (fr) * 1990-10-05 1992-04-10 Rhone Poulenc Sante Polypeptides derives de l'interleukine-1 beta, procede de preparation et utilisation, notamment dans le cadre des pathologies osteoarticulaires.
US7176179B1 (en) 1997-05-30 2007-02-13 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
US20030154504A1 (en) 1998-06-24 2003-08-14 Farese Robert V. Methods and compositions for modulating carbohydrate metabolism

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0188920B1 (en) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin 1 and its derivative
EP0200986B2 (en) * 1985-04-25 1998-03-11 F. Hoffmann-La Roche Ag Recombinant human interleukin-1
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
JP2591615B2 (ja) * 1986-03-14 1997-03-19 大塚製薬株式会社 インターロイキン−１β誘導体及び医薬
US5017692A (en) * 1986-09-04 1991-05-21 Schering Corporation Truncated human interleukin-a alpha

Also Published As

Publication number Publication date
JP2698976B2 (ja) 1998-01-19
EP0327360B1 (en) 1994-07-06
DE68916559T2 (de) 1994-11-03
JPH01199998A (ja) 1989-08-11
EP0327360A2 (en) 1989-08-09
KR960016705B1 (ko) 1996-12-20
EP0327360A3 (en) 1990-05-02
KR890013177A (ko) 1989-09-21
ATE108207T1 (de) 1994-07-15
DE68916559D1 (de) 1994-08-11

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