ES2058651T3 - Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy. - Google Patents

Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy.

Info

Publication number
ES2058651T3
ES2058651T3 ES90106200T ES90106200T ES2058651T3 ES 2058651 T3 ES2058651 T3 ES 2058651T3 ES 90106200 T ES90106200 T ES 90106200T ES 90106200 T ES90106200 T ES 90106200T ES 2058651 T3 ES2058651 T3 ES 2058651T3
Authority
ES
Spain
Prior art keywords
manufacture
npy
medicine
guanidine derivatives
antagonist activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90106200T
Other languages
English (en)
Inventor
Martin C Dr Michel
Johann Peter Dr Dipl- Morsdorf
Heidrun Dr Engler
Helmut Dr Dipl-Ch Schickaneder
Kurt-Henning Dr Ahrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Pharma GmbH and Co
Original Assignee
Heumann Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma GmbH and Co filed Critical Heumann Pharma GmbH and Co
Application granted granted Critical
Publication of ES2058651T3 publication Critical patent/ES2058651T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

LA INVENCION DESCRIBE LA APLICACION DE DERIVADOS DE GUANIDINA CON ESTRUCTURA PRINCIPAL DE FORMULA (I) PARA LA PRODUCCION DE MEDICAMENTOS CON ACCION ANTAGONISTICA NPY Y PARA LA OBTENCION DE MEDICAMENTOS PARA EL TRATAMIENTO DE LA ELEVADA PRESION SANGUINEA.
ES90106200T 1990-03-30 1990-03-30 Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy. Expired - Lifetime ES2058651T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90106200A EP0448765B1 (de) 1990-03-30 1990-03-30 Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung

Publications (1)

Publication Number Publication Date
ES2058651T3 true ES2058651T3 (es) 1994-11-01

Family

ID=8203843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90106200T Expired - Lifetime ES2058651T3 (es) 1990-03-30 1990-03-30 Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy.

Country Status (14)

Country Link
EP (1) EP0448765B1 (es)
JP (1) JPH0789939A (es)
KR (1) KR910016329A (es)
AT (1) ATE109979T1 (es)
AU (1) AU637882B2 (es)
CA (1) CA2037433A1 (es)
DE (1) DE59006842D1 (es)
DK (1) DK0448765T3 (es)
ES (1) ES2058651T3 (es)
HU (1) HU207945B (es)
IE (1) IE65252B1 (es)
IL (1) IL97424A (es)
PT (1) PT97138A (es)
ZA (1) ZA911471B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012139A1 (en) * 1991-12-19 1993-06-24 Garvan Institute Of Medical Research A novel molecule which inhibits neuropeptide tyrosine biological function
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) * 1994-02-03 1996-08-13 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5602024A (en) * 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5989920A (en) 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
AU7692896A (en) * 1995-12-01 1997-06-27 Novartis Ag Quinazolin-2,4-diazirines as NPY receptor antagonist
WO1997020823A2 (en) * 1995-12-01 1997-06-12 Novartis Ag 2-amino quinazoline derivatives as npy receptor antagonists
EP0912551A1 (en) * 1996-05-14 1999-05-06 Novo Nordisk A/S Somatostatin agonists and antagonists
DE69713402T2 (de) * 1996-08-23 2002-11-07 Agouron Pharma Liganden des neuropeptids y
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
JP2001502712A (ja) * 1996-10-31 2001-02-27 ノボ ノルディスク アクティーゼルスカブ 束縛されたソマトスタチン・アゴニスト及びアンタゴニスト
WO1998035957A1 (en) * 1997-02-14 1998-08-20 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists
EP0927166A1 (en) * 1997-02-14 1999-07-07 Bayer Corporation Amides as npy5 receptor antagonists
US6048900A (en) * 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
US6245817B1 (en) 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
PL337887A1 (en) 1997-07-03 2000-09-11 Neurogen Corp Some diarylimidazole derivatives, novel class of specific npy ligands
ES2161594B1 (es) * 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AU2935200A (en) 1999-04-30 2000-11-17 Pfizer Products Inc. Compounds for the treatment of obesity
ES2311544T3 (es) 2000-09-20 2009-02-16 Schering Corp Imidazoles sustituidos como agonistas o antagonistas duales de histamina h1 y h3.
ES2313985T3 (es) 2000-09-20 2009-03-16 Schering Corporation Imidazoles sutituidos como agonistas o antagonistas de histamina h1 y h3.
EP1318996B1 (en) 2000-09-20 2004-12-01 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
WO2002024659A2 (en) 2000-09-20 2002-03-28 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199845B1 (de) * 1985-04-02 1990-08-01 HEUMANN PHARMA GMBH & CO Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0448765A1 (de) 1991-10-02
ATE109979T1 (de) 1994-09-15
AU637882B2 (en) 1993-06-10
HU910979D0 (en) 1991-10-28
PT97138A (pt) 1991-11-29
JPH0789939A (ja) 1995-04-04
CA2037433A1 (en) 1991-10-01
IL97424A (en) 1995-05-26
IE65252B1 (en) 1995-10-18
AU7206891A (en) 1991-10-03
HU207945B (en) 1993-07-28
DE59006842D1 (de) 1994-09-22
KR910016329A (ko) 1991-11-05
HUT57044A (en) 1991-11-28
IL97424A0 (en) 1992-06-21
EP0448765B1 (de) 1994-08-17
ZA911471B (en) 1991-11-27
IE910995A1 (en) 1991-10-09
DK0448765T3 (da) 1994-09-19

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