ES2058576T3 - Compuestos activos sobre las formas tisulares de la malaria y procedimiento de preparacion. - Google Patents

Compuestos activos sobre las formas tisulares de la malaria y procedimiento de preparacion.

Info

Publication number
ES2058576T3
ES2058576T3 ES89402593T ES89402593T ES2058576T3 ES 2058576 T3 ES2058576 T3 ES 2058576T3 ES 89402593 T ES89402593 T ES 89402593T ES 89402593 T ES89402593 T ES 89402593T ES 2058576 T3 ES2058576 T3 ES 2058576T3
Authority
ES
Spain
Prior art keywords
free amine
acid
peptide
amino acid
carboxyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89402593T
Other languages
English (en)
Inventor
Philippe Pirson
Jean-Bernard Falmagne
Andre Trouet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
La Region Wallonne
Original Assignee
La Region Wallonne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by La Region Wallonne filed Critical La Region Wallonne
Application granted granted Critical
Publication of ES2058576T3 publication Critical patent/ES2058576T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE QUINOLEINA QUE CONTIENEN UNA FUNCION AMINA LIBRE Y QUE TIENEN PROPIEDADES ANTIMALARICAS, EN ESPECIAL A NUEVOS DERIVADOS DE LA PRIMAQUINA O SUS SALES DE ADICION CON ACIDO Y PROCEDIMIENTO PARA SU OBTENCION. SEGUN LA INVENCION, ESTOS NUEVOS DERIVADOS ESTAN REPRESENTADOS ESQUEMATICAMENTE POR LA FORMULA PQ-X, EN LA QUE PQ REPRESENTA QUINOLEINAS QUE CONTIENEN UNA FUNCION AMINA LIBRE Y QUE TIENEN PROPIEDADES ANTIMALARICAS, EN PARTICULAR LA PRIMAQUINA; X REPRESENTA UN AMINOACIDO O UN PEPTIDO DE 2-4 AMINOACIDOS; SIENDO LA UNION PQ-X UNA UNION COVALENTE PEPTIDICA ENTRE EL GRUPO AMINA LIBRE DE PQ Y EL GRUPO CARBOXILICO DE X, SIENDO ESTABLE LA UNION PQ-X EN EL SUERO Y RESISTENTE A LAS HIDROLASAS LISOSOMIALES. EN UNA FORMA DE REALIZACION DE LA INVENCION, EL AMINOACIDO O EL PRIMER AMINOACIDO DE PEPTIDO UNIDO A PQ ES EL ACIDO (TAU) L-GLUTAMICO O EL ACIDO (BETA)-ASPARTICO UNIDO A PQ POR SU GRUPO (TAU)- O (BETA)-CARBOXILO, O EL ACIDO L-PIROGLUTAMICO, O EL ACIDO ASPARTICO UNIDO A PQ POR SU GRUPO (ALFA)-CARBOXILO.
ES89402593T 1988-09-23 1989-09-21 Compuestos activos sobre las formas tisulares de la malaria y procedimiento de preparacion. Expired - Lifetime ES2058576T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8812441A FR2644462B1 (fr) 1988-09-23 1988-09-23 Nouveaux composes actifs sur les formes tissulaires de la malaria et procede de preparation

Publications (1)

Publication Number Publication Date
ES2058576T3 true ES2058576T3 (es) 1994-11-01

Family

ID=9370310

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89402593T Expired - Lifetime ES2058576T3 (es) 1988-09-23 1989-09-21 Compuestos activos sobre las formas tisulares de la malaria y procedimiento de preparacion.

Country Status (7)

Country Link
US (1) US5110935A (es)
EP (1) EP0362031B1 (es)
JP (1) JPH02129170A (es)
AT (1) ATE91283T1 (es)
DE (1) DE68907458T2 (es)
ES (1) ES2058576T3 (es)
FR (1) FR2644462B1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510356A (en) * 1991-10-03 1996-04-23 University Of Nebraska Board Of Regents Bisquinolines and processes for their production and use to treat malaria
NZ332197A (en) * 1996-03-29 2000-06-23 Univ Mississippi 8-aminoquinolines comprising a triple phenoxy substitution for antiparasitic treatment
AU780973B2 (en) * 1999-06-25 2005-04-28 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of IMPDH
WO2004085402A1 (en) * 2003-03-27 2004-10-07 Council Of Scientific And Industrial Research Ring-substituted 8-aminoqunoline derivates as antimalarial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0037388B1 (fr) * 1980-03-31 1984-12-12 Institut International De Pathologie Cellulaire Et Moleculaire Formes pharmaceutiques, leur préparation et les compositions qui les contiennent
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2612778B1 (fr) * 1987-03-24 1991-10-18 Ire Cell Targ Sa Nouveaux derives d'aminoquinoleine antimalarique, procede de preparation et composition pharmaceutique en contenant
FR2618674B1 (fr) * 1987-07-30 1990-06-15 Ire Celltarg Sa Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation

Also Published As

Publication number Publication date
EP0362031B1 (fr) 1993-07-07
US5110935A (en) 1992-05-05
ATE91283T1 (de) 1993-07-15
DE68907458T2 (de) 1993-12-16
JPH02129170A (ja) 1990-05-17
FR2644462B1 (fr) 1993-07-09
EP0362031A1 (fr) 1990-04-04
FR2644462A1 (fr) 1990-09-21
DE68907458D1 (de) 1993-08-12

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