ES2077582T3 - Derivados de proteinas y un procedimiento para su preparacion. - Google Patents
Derivados de proteinas y un procedimiento para su preparacion.Info
- Publication number
- ES2077582T3 ES2077582T3 ES89308681T ES89308681T ES2077582T3 ES 2077582 T3 ES2077582 T3 ES 2077582T3 ES 89308681 T ES89308681 T ES 89308681T ES 89308681 T ES89308681 T ES 89308681T ES 2077582 T3 ES2077582 T3 ES 2077582T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- group
- peptide
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
DERIVADOS DE LA PROTEINA DE FORMULA (I), DONDE A-CO ES UN RESIDUO DE UNA PROTEINA O PEPTIDO A-CO2H (ESPECIALMENTE DONDE -CO2H ES EL GRUPO CARBOXILICO TERMINAL -C DE LA PROTEINA O PEPTIDO); R1, R2, R3 Y R4 PUEDEN SER IGUALES O DIFERENTES Y PUEDEN ESTAR PRESENTES O AUSENTES EN CADA UNO DE ELLOS, V UN GRUPO ESPACIADOR, X ES UN OXIGENO O UN ATOMO DE SULFURO; Y LAS SALES DEL MISMO. LOS COMPUESTOS PUEDEN SER PREPARADOS POR UNA REACCION CONDENSACION, ESPECIALMENTE EN LA PRESENCIA DE UNA ENZIMA CAPAZ DE CATALIZAR LA FORMACION DE UN ENLACE PEPTIDO. LOS COMPUESTOS PUEDEN SER USADOS PARA FORMAR PROTEINAS CONJUGADAS EN LAS CUALES UN GRUPO DE INTERES COMO SON OTRA PROTEINA O PEPTIDO O UN GRUPO REPORTADOR REALIZADOR ES ACOPLADO A LA PROTEINA A TRAVES DE UN GRUPO -N (R'') N (R2) - Z'' - C (=X) - Z2 - N (R3) N.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888820378A GB8820378D0 (en) | 1988-08-26 | 1988-08-26 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2077582T3 true ES2077582T3 (es) | 1995-12-01 |
Family
ID=10642823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89308681T Expired - Lifetime ES2077582T3 (es) | 1988-08-26 | 1989-08-25 | Derivados de proteinas y un procedimiento para su preparacion. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0359428B1 (es) |
JP (1) | JP2778775B2 (es) |
AT (1) | ATE126236T1 (es) |
AU (1) | AU637326B2 (es) |
DE (1) | DE68923746T2 (es) |
ES (1) | ES2077582T3 (es) |
GB (1) | GB8820378D0 (es) |
GR (1) | GR3017089T3 (es) |
WO (1) | WO1990002136A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8610551D0 (en) | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
US6673347B1 (en) | 1986-04-30 | 2004-01-06 | Gryphon Therapeutics | Polypeptide and protein derivatives and process for their preparation |
GB9004538D0 (en) * | 1990-02-28 | 1990-04-25 | Offord Robin E | Chemical compounds |
AU8091091A (en) * | 1990-07-26 | 1992-02-18 | University Of Iowa Research Foundation, The | Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule |
US5272253A (en) * | 1991-07-01 | 1993-12-21 | Eli Lilly And Company | Cluster conjugates of drugs with antibodies |
GB9525955D0 (en) * | 1995-12-19 | 1996-02-21 | Therexsys Ltd | Improved pharmaceutical compositions |
US5830852A (en) * | 1995-12-19 | 1998-11-03 | Cobra Therapeutics, Ltd. | Compositions for insulin-receptor mediated nucleic acid delivery |
US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
WO2006080017A2 (en) * | 2005-01-26 | 2006-08-03 | Ramot At Tel Aviv University Ltd. | Biologically active silver-coated proteins |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL71947A (en) * | 1984-05-29 | 1987-10-30 | Yeda Research And Dev Comp Ltd | Enzyme hydrazides and method for detection and determination of glycoconjugates |
EP0305967B1 (de) * | 1987-09-02 | 1993-05-05 | Ciba-Geigy Ag | Konjugate von Interferon alpha mit Immunglobulinen |
-
1988
- 1988-08-26 GB GB888820378A patent/GB8820378D0/en active Pending
-
1989
- 1989-08-25 JP JP1509484A patent/JP2778775B2/ja not_active Expired - Lifetime
- 1989-08-25 DE DE68923746T patent/DE68923746T2/de not_active Expired - Fee Related
- 1989-08-25 ES ES89308681T patent/ES2077582T3/es not_active Expired - Lifetime
- 1989-08-25 AU AU41906/89A patent/AU637326B2/en not_active Ceased
- 1989-08-25 WO PCT/GB1989/000994 patent/WO1990002136A1/en unknown
- 1989-08-25 EP EP89308681A patent/EP0359428B1/en not_active Expired - Lifetime
- 1989-08-25 AT AT89308681T patent/ATE126236T1/de not_active IP Right Cessation
-
1995
- 1995-08-10 GR GR950401930T patent/GR3017089T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE126236T1 (de) | 1995-08-15 |
EP0359428B1 (en) | 1995-08-09 |
AU637326B2 (en) | 1993-05-27 |
DE68923746T2 (de) | 1996-03-21 |
AU4190689A (en) | 1990-03-23 |
JPH03501623A (ja) | 1991-04-11 |
GR3017089T3 (en) | 1995-11-30 |
GB8820378D0 (en) | 1988-09-28 |
JP2778775B2 (ja) | 1998-07-23 |
WO1990002136A1 (en) | 1990-03-08 |
DE68923746D1 (de) | 1995-09-14 |
EP0359428A1 (en) | 1990-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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