ES2058423T3 - Composicion de factor de crecimiento de fibroblastos, resistente a los acidos, para tratar enfermedades ulcerantes del tracto gastrointestinal. - Google Patents
Composicion de factor de crecimiento de fibroblastos, resistente a los acidos, para tratar enfermedades ulcerantes del tracto gastrointestinal.Info
- Publication number
- ES2058423T3 ES2058423T3 ES89115252T ES89115252T ES2058423T3 ES 2058423 T3 ES2058423 T3 ES 2058423T3 ES 89115252 T ES89115252 T ES 89115252T ES 89115252 T ES89115252 T ES 89115252T ES 2058423 T3 ES2058423 T3 ES 2058423T3
- Authority
- ES
- Spain
- Prior art keywords
- growth factor
- fibroblast growth
- treating
- gastrointestinal tract
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000018233 Fibroblast Growth Factor Human genes 0.000 title abstract 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 title abstract 4
- 229940126864 fibroblast growth factor Drugs 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 210000001035 gastrointestinal tract Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
ESTE INVENTO DESCRIBE COMPOSICIONES FARMACEUTICAS Y METODOS DE TRATAR ENFERMEDADES ULCEROSAS DEL APARATO GASTROINTESTINAL EN MAMIFEROS CON UNAS COMPOSICIONES DE FACTOR DE CRECIMIENTO DE FIBROBLASTO RESISTENTE DE ACIDO. TAMBIEN ES DESCRITO EL USO DE COMPOSICIONES DE FACTOR DE CRECIMIENTO DE FIBROBLASTO RESISTENTE DE ACIDO EN EL TRATAMIENTO DE VARIAS OTRAS CONDICIONES SENSIBLES DE FACTOR DE CRECIMIENTO DE FIBROBLASTO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23496688A | 1988-08-19 | 1988-08-19 | |
US07/382,263 US5175147A (en) | 1988-08-19 | 1989-07-20 | Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058423T3 true ES2058423T3 (es) | 1994-11-01 |
Family
ID=26928432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89115252T Expired - Lifetime ES2058423T3 (es) | 1988-08-19 | 1989-08-18 | Composicion de factor de crecimiento de fibroblastos, resistente a los acidos, para tratar enfermedades ulcerantes del tracto gastrointestinal. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5175147A (es) |
EP (1) | EP0360006B1 (es) |
JP (1) | JP2501480B2 (es) |
KR (1) | KR920700040A (es) |
CN (1) | CN1040741A (es) |
AT (1) | ATE91628T1 (es) |
CA (1) | CA1330757C (es) |
DE (1) | DE68907679T2 (es) |
DK (1) | DK93890D0 (es) |
ES (1) | ES2058423T3 (es) |
FI (2) | FI901949A0 (es) |
HU (1) | HU207227B (es) |
IE (1) | IE63046B1 (es) |
IL (1) | IL91322A (es) |
NO (1) | NO901710L (es) |
WO (1) | WO1990001941A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5202311A (en) * | 1988-08-19 | 1993-04-13 | Children's Medical Center Corporation | Stabilized fgf composition |
JPH0343088A (ja) * | 1989-09-29 | 1991-02-25 | Takeda Chem Ind Ltd | aFGF蛋白質の製造法 |
EP0406738A3 (en) * | 1989-07-03 | 1991-08-14 | Takeda Chemical Industries, Ltd. | Production of acidic fgf protein |
CA2020720A1 (en) * | 1989-07-13 | 1991-01-14 | Shigeko Yamazaki | Method for the purification of therapeutically active recombinant acidic fibroblast growth factor |
AUPN271295A0 (en) | 1995-05-02 | 1995-05-25 | Gropep Pty Ltd | Method of treatment |
US5972884A (en) * | 1991-03-11 | 1999-10-26 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
US6399569B1 (en) | 1991-03-11 | 2002-06-04 | Curis, Inc. | Morphogen treatments for limiting proliferation of epithelial cells |
JPH06506939A (ja) * | 1991-04-12 | 1994-08-04 | クリエイティブ バイオモレキュルズ インコーポレイテッド | 血小板由来の成長因子に依る消化管潰瘍の治療方法 |
NO921495L (no) * | 1991-04-16 | 1992-10-19 | Seikagaku Kogyo Co Ltd | Oligosakkarid og fremgangsmaate for dets fremstilling |
US6190864B1 (en) * | 1991-05-08 | 2001-02-20 | Chiron Corporation | HCV genomic sequences for diagnostics and therapeutics |
US5348941A (en) * | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
AU685058B2 (en) * | 1992-06-16 | 1998-01-15 | Selective Genetics, Inc. | Recombinant production of saporin-containing proteins |
US5464815A (en) * | 1993-09-08 | 1995-11-07 | Genentech, Inc. | Inhibition of heparin-binding |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
FR2718023B1 (fr) * | 1994-03-30 | 1996-08-14 | Paris Val Marne Universite | Médicament et composition pharmaceutique pour le traitement de lésions du tractus digestif. |
US5783568A (en) * | 1994-06-10 | 1998-07-21 | Sugen, Inc. | Methods for treating cancer and other cell proliferative diseases |
US5531880A (en) * | 1994-09-13 | 1996-07-02 | Microelectronics And Computer Technology Corporation | Method for producing thin, uniform powder phosphor for display screens |
FR2724665B1 (fr) * | 1994-09-16 | 1996-12-20 | Rhone Poulenc Rorer Sa | Procede de production de proteines recombinantes, plasmides et cellules modifiees |
US5593696A (en) * | 1994-11-21 | 1997-01-14 | Mcneil-Ppc, Inc. | Stabilized composition of famotidine and sucralfate for treatment of gastrointestinal disorders |
US5538737A (en) * | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
AU2001284914B2 (en) * | 2000-08-15 | 2006-02-09 | New Technologies Holdings Pte Ltd | Phage-dependent superproduction of biologically active protein and peptides |
US7754686B2 (en) * | 2000-08-31 | 2010-07-13 | Novartis Vaccines And Diagnostics, Inc. | Stabilized FGF formulations containing reducing agents |
EP3752174A4 (en) * | 2018-02-13 | 2021-11-17 | University of Florida Research Foundation, Incorporated | ANALOGUES OF FIBROBLASTS GROWTH FACTOR AND THEIR USES |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4296100A (en) * | 1980-06-30 | 1981-10-20 | Franco Wayne P | Method of treating the heart for myocardial infarction |
EP0105014B1 (en) * | 1982-09-24 | 1992-05-20 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Repair of tissue in animals |
JPS6034997A (ja) * | 1983-05-09 | 1985-02-22 | ジヨージ、ジヨセフ、トダロ | 生物学的活性ポリペプチド類 |
JPS6028999A (ja) * | 1983-06-30 | 1985-02-14 | Maruho Kk | 細胞増殖促進作用を有するたんぱく質、その組成物と製造方法 |
US4745098A (en) * | 1984-02-24 | 1988-05-17 | The Regents Of The University Of California | Compositions and method for improving wound healing |
CA1207239A (en) * | 1984-08-10 | 1986-07-08 | Upendra K. Banik | Gastrointestinal compositions |
JPS6172947A (ja) * | 1984-09-18 | 1986-04-15 | Takasago Thermal Eng Co Ltd | クリ−ンル−ムの形成法およびこの方法に使用する空気調和設備ユニツト |
IE66689B1 (en) * | 1985-09-12 | 1996-01-24 | Scios Nova Inc | Recombinant fibroblast growth factors |
DK122687A (da) * | 1986-03-14 | 1987-09-15 | Takeda Chemical Industries Ltd | Polypeptid, dna og anvendelse deraf |
CA1294546C (en) * | 1986-04-23 | 1992-01-21 | John S. Sundsmo | Wound healing composition containing collagen |
NZ220917A (en) * | 1986-07-11 | 1991-05-28 | Merck & Co Inc | Human and bovine acidic fibroblast growth factor vectors, hosts and compositions |
CA1323317C (en) * | 1987-01-16 | 1993-10-19 | Allen R. Banks | Production of fibroblast growth factor |
EP0377579A1 (en) * | 1987-07-07 | 1990-07-18 | California Biotechnology, Inc. | Recombinant fibroblast growth factors |
WO1989004832A1 (en) * | 1987-11-24 | 1989-06-01 | Amgen Inc. | Analogs of fibroblast growth factor |
AU614137B2 (en) * | 1988-06-06 | 1991-08-22 | Takeda Chemical Industries Ltd. | Stabilized fgf composition and production thereof |
JPH0240399A (ja) * | 1988-07-27 | 1990-02-09 | Takeda Chem Ind Ltd | 線維芽細胞増殖因子ムテインの複合体あるいは組成物 |
-
1989
- 1989-07-20 US US07/382,263 patent/US5175147A/en not_active Expired - Fee Related
- 1989-08-11 JP JP1509678A patent/JP2501480B2/ja not_active Expired - Lifetime
- 1989-08-11 WO PCT/US1989/003467 patent/WO1990001941A1/en active Application Filing
- 1989-08-11 KR KR1019900700801A patent/KR920700040A/ko not_active IP Right Cessation
- 1989-08-11 HU HU895785A patent/HU207227B/hu not_active IP Right Cessation
- 1989-08-15 IL IL9132289A patent/IL91322A/en unknown
- 1989-08-18 AT AT89115252T patent/ATE91628T1/de not_active IP Right Cessation
- 1989-08-18 ES ES89115252T patent/ES2058423T3/es not_active Expired - Lifetime
- 1989-08-18 IE IE266489A patent/IE63046B1/en not_active IP Right Cessation
- 1989-08-18 DE DE89115252T patent/DE68907679T2/de not_active Expired - Fee Related
- 1989-08-18 EP EP89115252A patent/EP0360006B1/en not_active Expired - Lifetime
- 1989-08-18 CA CA000608827A patent/CA1330757C/en not_active Expired - Fee Related
- 1989-08-19 CN CN89106448A patent/CN1040741A/zh active Pending
-
1990
- 1990-04-17 DK DK093890A patent/DK93890D0/da not_active Application Discontinuation
- 1990-04-18 FI FI901949A patent/FI901949A0/fi not_active IP Right Cessation
- 1990-04-18 NO NO90901710A patent/NO901710L/no unknown
-
1992
- 1992-04-03 US US07/862,776 patent/US5401721A/en not_active Expired - Fee Related
-
1994
- 1994-06-22 FI FI943028A patent/FI943028A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HU207227B (en) | 1993-03-29 |
DE68907679D1 (de) | 1993-08-26 |
EP0360006A2 (en) | 1990-03-28 |
IE892664L (en) | 1990-02-19 |
ATE91628T1 (de) | 1993-08-15 |
IL91322A (en) | 1994-12-29 |
DE68907679T2 (de) | 1994-01-27 |
AU630111B2 (en) | 1992-10-22 |
FI901949A0 (fi) | 1990-04-18 |
HUT55638A (en) | 1991-06-28 |
EP0360006B1 (en) | 1993-07-21 |
FI943028A0 (fi) | 1994-06-22 |
CN1040741A (zh) | 1990-03-28 |
JPH03505736A (ja) | 1991-12-12 |
CA1330757C (en) | 1994-07-19 |
WO1990001941A1 (en) | 1990-03-08 |
US5401721A (en) | 1995-03-28 |
IE63046B1 (en) | 1995-03-22 |
AU4218989A (en) | 1990-03-23 |
EP0360006A3 (en) | 1990-04-04 |
HU895785D0 (en) | 1990-12-28 |
NO901710D0 (no) | 1990-04-18 |
IL91322A0 (en) | 1990-03-19 |
DK93890A (da) | 1990-04-17 |
NO901710L (no) | 1990-04-18 |
JP2501480B2 (ja) | 1996-05-29 |
DK93890D0 (da) | 1990-04-17 |
FI943028A (fi) | 1994-06-22 |
KR920700040A (ko) | 1992-02-19 |
US5175147A (en) | 1992-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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