ES2058252T3 - Arnasa l activada como marcador para infecciones viricas. - Google Patents

Arnasa l activada como marcador para infecciones viricas.

Info

Publication number
ES2058252T3
ES2058252T3 ES88301819T ES88301819T ES2058252T3 ES 2058252 T3 ES2058252 T3 ES 2058252T3 ES 88301819 T ES88301819 T ES 88301819T ES 88301819 T ES88301819 T ES 88301819T ES 2058252 T3 ES2058252 T3 ES 2058252T3
Authority
ES
Spain
Prior art keywords
pathway
rnase
aids
biochemical
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88301819T
Other languages
English (en)
Inventor
William A Carter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEM Pharmaceuticals Corp
Original Assignee
HEM Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HEM Pharmaceuticals Corp filed Critical HEM Pharmaceuticals Corp
Application granted granted Critical
Publication of ES2058252T3 publication Critical patent/ES2058252T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/922—Ribonucleases (RNAses); Deoxyribonucleases (DNAses)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

UNA PRIMERALINEA DE DEFENSA CELULAR CONTRA MUCHOS VIRUS, INCLUEYNDO AQUELLOS CAUSANTES DE SIDA, ES LA ACTIVACION DE UN SISTEMA BIOQUIMICO INTRACELULAR DEIMINADO COMO TRAYECTORIA DE 2''-5'' OLIGOADENILATO/RNASA. ES BIEN CONOCIDO QUE ESTA TRAYECTORIA FUNCIONA MAL EN INDIVIDUOS CON DISFUNCION INMUNE RELATIVA AL SIDA PROGRESIVA, PERO EL MECANISMO DEL M,AL FUNCINAMIENTO PERMANECE OSCURO. UNA SUSTANCIA INHIBIDORA, LIBERADA EN CELULAS INFECTDAS DE HIV O UN INHIBIDOR DIRIGIDO AL VIRUS DE COMPUESTOS INTERMEDIOS BIOQUIMICOS EN LA TRAYECTORIA 2''-5''A/RNASA, QUE POR ATAQUE APARENTEMENTE FISICO AL PRODUCTO TERMINAL (RNASAL) EN LA TRAYECTORIA BIOQUIMICA, HACE QUE EL SISTEMA COMPLETO FUNCIONE MAL, LO QUE PERMITE AL HIV MULTIPLICERSE INCONTROLABLEMENTE, NO HA SIDO INDENTIFICADO HASTA AHORA. EL NIVEL INTRACELULAR RELATIVO DE ESTE INHIBIDOR RECIENTEMENTE AISLADO TIENE SIGNIFICANCIA COMO PRONOSTICO CON RESPECTO AL DESARROLLO DE SID COMPLETAMENTE DIFUNDIDO Y MUERTE EVENTUAL.
ES88301819T 1987-03-03 1988-03-02 Arnasa l activada como marcador para infecciones viricas. Expired - Lifetime ES2058252T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2137287A 1987-03-03 1987-03-03

Publications (1)

Publication Number Publication Date
ES2058252T3 true ES2058252T3 (es) 1994-11-01

Family

ID=21803819

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88301819T Expired - Lifetime ES2058252T3 (es) 1987-03-03 1988-03-02 Arnasa l activada como marcador para infecciones viricas.

Country Status (20)

Country Link
EP (1) EP0285263B1 (es)
JP (1) JPH0675520B2 (es)
KR (1) KR880011593A (es)
AT (1) ATE107964T1 (es)
AU (1) AU618525B2 (es)
CA (1) CA1337278C (es)
DE (1) DE3850428T2 (es)
DK (1) DK112888A (es)
ES (1) ES2058252T3 (es)
FI (1) FI880959A (es)
IE (1) IE66831B1 (es)
IL (1) IL85576A0 (es)
MX (1) MX173802B (es)
NO (1) NO880934L (es)
NZ (1) NZ223721A (es)
OA (1) OA08720A (es)
PH (1) PH30882A (es)
PT (1) PT86878B (es)
RU (1) RU2049336C1 (es)
ZA (1) ZA881471B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593973A (en) * 1987-09-04 1997-01-14 Hemispherx Biopharma Inc. Treatment of viral hepatitis with mismatched dsRNA
DE3853755T2 (de) * 1987-09-04 1995-12-14 Hem Pharma Corp Diagnose von Mangelzuständen doppelsträngiger RNS.
AU724056B2 (en) * 1987-09-04 2000-09-14 Hem Research, Inc. Diagnosis and treatment of double stranded deficiency states
ATE103493T1 (de) * 1988-07-07 1994-04-15 Hem Pharma Corp Diagnose und behandlung chronischer ermuedungserscheinungen.
US5985565A (en) * 1996-10-09 1999-11-16 Temple University-Of The Commonwealth System Of Higher Education Chronic fatigue syndrome diagnosis
US6207366B1 (en) 1999-04-14 2001-03-27 Temple University- Of The Commonwealth System Of Higher Education Chronic fatigue syndrome diagnosis
US6080554A (en) * 1999-04-27 2000-06-27 R.E.D. Laboratories, N.V. Methods and compositions for use in characterizing multiple sclerosis disease activity in a subject
WO2017193051A1 (en) * 2016-05-06 2017-11-09 The Trustees Of Princeton University Methods of monitoring rnase l activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3380200D1 (en) * 1982-09-16 1989-08-24 William Alvin Carter Anti-proliferative action of dsnras on tumor cells
CA1326450C (en) * 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)

Also Published As

Publication number Publication date
IE880587L (en) 1988-09-03
DK112888D0 (da) 1988-03-02
DE3850428T2 (de) 1994-11-24
PT86878B (pt) 1992-05-29
PT86878A (pt) 1988-04-01
NO880934L (no) 1988-09-05
IL85576A0 (en) 1988-08-31
PH30882A (en) 1997-12-23
CA1337278C (en) 1995-10-10
AU618525B2 (en) 1992-01-02
ATE107964T1 (de) 1994-07-15
NZ223721A (en) 1991-02-26
EP0285263A2 (en) 1988-10-05
OA08720A (en) 1989-03-31
DK112888A (da) 1988-09-04
EP0285263B1 (en) 1994-06-29
JPH0675520B2 (ja) 1994-09-28
NO880934D0 (no) 1988-03-02
AU1256388A (en) 1988-09-01
RU2049336C1 (ru) 1995-11-27
JPS63309200A (ja) 1988-12-16
FI880959A0 (fi) 1988-03-02
DE3850428D1 (de) 1994-08-04
EP0285263A3 (en) 1990-04-18
ZA881471B (en) 1988-12-28
KR880011593A (ko) 1988-10-29
MX173802B (es) 1994-03-29
IE66831B1 (en) 1996-02-07
FI880959A (fi) 1988-09-04

Similar Documents

Publication Publication Date Title
AU6497694A (en) Method for selective inactivation of viral replication
ES2058252T3 (es) Arnasa l activada como marcador para infecciones viricas.
WO2003079757A3 (en) Hiv therapeutic
AU2022295A (en) Nucleic acid amplification with DNA-dependant RNA polymerase activity of RNA replicases
FI883763A0 (fi) Frigoering av vaerdens foersvarsmediatorer i biologiska vaetskor genom systematisk behandling med dubbelstraengat rna.
ES2033018T3 (es) Casco de fragmentacion para cuerpos explosivos y procedimientos para su fabricacion.
ES2108969T3 (es) Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales.
AU590817B2 (en) Antiviral combinations
SE8601435D0 (sv) Aktivt pansar
ZA881512B (en) Synergistic interplay of lymphokines and double-stranded rnas
EP0135713A3 (en) Antiviral combinations
DK615788A (da) Nucleosidforbindelser til anvendelse mod virale infektioner
IT8709410A0 (it) Arma giocattolo per il lancio pneumatico di proiettili,con il pistone del sistema cilindropistone combinato al cane,dell'arma
WO1988007080A3 (en) Transgenic animal cells resistant to viral infection
DE69718911D1 (de) Interleukin - 8 als antivirale- und antitumorwirkstoffe
ES2053601T3 (es) Agentes de biocontrol fundidos.
NO985110L (no) Eksplosivformuleringer
Pravdina et al. Inhibiting effect of adenylyl-(3'-5')-ribavirin on the activity of influenza A viral RNA polymerase.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 285263

Country of ref document: ES