ES2056465T3 - Nuevos agentes para la formacion de imagenes por resonancia magnetica. - Google Patents

Nuevos agentes para la formacion de imagenes por resonancia magnetica.

Info

Publication number
ES2056465T3
ES2056465T3 ES90907933T ES90907933T ES2056465T3 ES 2056465 T3 ES2056465 T3 ES 2056465T3 ES 90907933 T ES90907933 T ES 90907933T ES 90907933 T ES90907933 T ES 90907933T ES 2056465 T3 ES2056465 T3 ES 2056465T3
Authority
ES
Spain
Prior art keywords
magnetic resonance
representation
animal
new
images
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907933T
Other languages
English (en)
Inventor
Raghavan Rajagopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ES2056465T3 publication Critical patent/ES2056465T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Compounds Of Iron (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS NUEVOS AGENTES DE REPRESENTACION DE IMAGENES DE RESONANCIA MAGNETICA COMPRENDEN COMPLEJOS DE IONES PARAMAGNETICOS CON DERIVADOS DE HIDRACINA DE AGENTES ACIDO POLIAMINOCARBOXILICO. ESTOS NUEVOS AGENTES DE REPRESENTACION SE CARACTERIZAN POR EXCELENTES PROPIEDADES DE CONTRASTE DE IMAGEN NMR (NOVEL MAGNETIC RESONANCE) Y POR LA ALTA SOLUBILIDAD EN SOLUCIONES FISIOLOGICAS. EL NUEVO METODO DE LLEVAR A CABO UN PROCEDIMIENTO DIAGNOSTICO NMR IMPLICA ADMINISTRAR A UN ANIMAL DE SANGRE CALIENTE UNA CANTIDAD EFECTIVA DE UN COMPLEJO COMO EL ANTES DESCRITO Y LUEGO EXPONER AL ANIMAL DE SANGRE CALIENTE A UN PROCEDIMIENTO DE REPRESENTACION NMR, POR TANTO DANDO LA IMAGEN DE AL MENOS UNA PORCION DEL CUERPO DEL ANIMAL DE SANGRE CALIENTE.
ES90907933T 1989-04-24 1990-03-12 Nuevos agentes para la formacion de imagenes por resonancia magnetica. Expired - Lifetime ES2056465T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/341,978 US5384108A (en) 1989-04-24 1989-04-24 Magnetic resonance imaging agents

Publications (1)

Publication Number Publication Date
ES2056465T3 true ES2056465T3 (es) 1994-10-01

Family

ID=23339815

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907933T Expired - Lifetime ES2056465T3 (es) 1989-04-24 1990-03-12 Nuevos agentes para la formacion de imagenes por resonancia magnetica.

Country Status (10)

Country Link
US (2) US5384108A (es)
EP (1) EP0470188B1 (es)
JP (1) JP3040462B2 (es)
AT (1) ATE106751T1 (es)
AU (1) AU640140B2 (es)
CA (1) CA2051815A1 (es)
DE (1) DE69009758T2 (es)
DK (1) DK0470188T3 (es)
ES (1) ES2056465T3 (es)
WO (1) WO1990012598A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
GB9115375D0 (en) * 1991-07-17 1991-09-04 Salutar Inc Compounds
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
US5858327A (en) * 1993-09-03 1999-01-12 Resolutions Pharmaceuticals, Inc. Hydrazino-type N2 S2 radionuclide chelating compounds
ATE164833T1 (de) * 1994-01-12 1998-04-15 Bracco Int Bv Liganden und deren metallkomplexe
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6153150A (en) * 1998-01-12 2000-11-28 Advanced Technology Materials, Inc. Apparatus and method for controlled decomposition oxidation of gaseous pollutants
US6596259B1 (en) 1998-12-22 2003-07-22 University Of Puerto Rico Metal based cubane structure contained in an octanuclear complex stable over several oxidation states and a method of producing the same
US7807137B1 (en) 1998-12-22 2010-10-05 University Of Puerto Rico Iron-based contrast agent

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DD45083A (es) *
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US3787482A (en) * 1966-09-20 1974-01-22 F Bersworth Method of synthesizing hydrazine compounds carboxylic acids
US3507892A (en) * 1967-08-17 1970-04-21 Weston Chemical Corp Heavy metal chelates of amino hydrazide chelating agents
US3565813A (en) * 1967-10-02 1971-02-23 Frederick C Bersworth Composite chelating compositions
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
US4001212A (en) * 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
DE2803528C2 (de) * 1977-03-09 1984-10-18 Tabushi, Iwao, Kyoto Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4965211A (en) * 1979-09-10 1990-10-23 Irwin Wieder Fluorometric analysis method
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3324236A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4609757A (en) * 1983-08-10 1986-09-02 Nuclear Technology Corporation Hydrazides of amino-polyacetic acids as chelants
CA1242643A (en) * 1983-08-12 1988-10-04 Eric T. Fossel Nmr imaging utilizing chemical shift reagents
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
US4687659A (en) * 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
EP0250358A3 (en) * 1986-06-20 1988-10-05 Schering Aktiengesellschaft Novel complex compounds
US5039512A (en) * 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3701665A1 (de) * 1987-01-19 1988-07-28 Schering Ag Polymer-komplexe, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4822594A (en) * 1987-01-27 1989-04-18 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
US5078986A (en) * 1989-02-15 1992-01-07 Mallinckrodt Medical, Inc. Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
EP0490897A1 (en) * 1989-09-05 1992-06-24 Mallinckrodt, Inc. Novel magnetic resonance imaging agents

Also Published As

Publication number Publication date
US5384108A (en) 1995-01-24
CA2051815A1 (en) 1990-10-25
EP0470188B1 (en) 1994-06-08
AU5535090A (en) 1990-11-16
WO1990012598A1 (en) 1990-11-01
JP3040462B2 (ja) 2000-05-15
ATE106751T1 (de) 1994-06-15
DE69009758D1 (de) 1994-07-14
DK0470188T3 (da) 1994-07-11
US5554357A (en) 1996-09-10
EP0470188A1 (en) 1992-02-12
DE69009758T2 (de) 1994-09-22
AU640140B2 (en) 1993-08-19
JPH04507097A (ja) 1992-12-10

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