ES2055740T3 - Procedimiento y equipo para la captacion de muestras de t-3 o t-4 homogeneas. - Google Patents
Procedimiento y equipo para la captacion de muestras de t-3 o t-4 homogeneas.Info
- Publication number
- ES2055740T3 ES2055740T3 ES88309122T ES88309122T ES2055740T3 ES 2055740 T3 ES2055740 T3 ES 2055740T3 ES 88309122 T ES88309122 T ES 88309122T ES 88309122 T ES88309122 T ES 88309122T ES 2055740 T3 ES2055740 T3 ES 2055740T3
- Authority
- ES
- Spain
- Prior art keywords
- thyroxine
- enzyme
- activity
- tbg
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA UN ENSAYO MEJORADO PARA MEDIR ASIMILACION DE TIROXINA QUE ENLAZA GLOBULINA, EN LA QUE LA ACTIVIDAD DE TIROXINA QUE ENLAZA GLOBULINA (TBG) SE MIDE DIRECTAMENTE. EL METODO CONSISTE EN COMBINAR UNA MUESTRA EN DISOLUCION ACUOSA CON UN CONJUGADO DONADOR DE ENZIMA (ED) CON UN ANALOGO DE POLIYODOTIRONINA, QUE COMPITE CON LA TIROXINA POR LOS PUNTOS DE UNION DE LA TIROXINA QUE ENLAZA GLOBULINA. UN ACEPTOR DE ENZIMAS (EA), CARACTERIADO POR PROPORCIONAR UNA ACTIVIDAD ENZIMATICA MODULADA EN RELACION CON LA CANTIDAD DE ACTIVIDAD TBG, SE COMBINA CON UN DONADOR DE ENZIMA Y LA MUESTRA EN UNA DISOLUCION ACUOSA. SE DETERMINA LA CANTIDAD DE ACTIVIDAD ENZIMATICA EN COMPARACION CON UNA DISOLUCION CONTROL, QUE TIENE UNA CANTIDAD CONOCIDA DE PUNTOS DE UNION TBG UTILIZABLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10434287A | 1987-10-02 | 1987-10-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2055740T3 true ES2055740T3 (es) | 1994-09-01 |
Family
ID=22299991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88309122T Expired - Lifetime ES2055740T3 (es) | 1987-10-02 | 1988-09-30 | Procedimiento y equipo para la captacion de muestras de t-3 o t-4 homogeneas. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0310430B1 (es) |
JP (1) | JP2579672B2 (es) |
AT (1) | ATE105414T1 (es) |
AU (1) | AU618022B2 (es) |
CA (1) | CA1317861C (es) |
DE (1) | DE3889407T2 (es) |
ES (1) | ES2055740T3 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1335707C (en) * | 1989-08-15 | 1995-05-30 | Pyare Khanna | Drug screening assay |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4171244A (en) * | 1975-02-20 | 1979-10-16 | Syva Company | Enzyme-bound-polyidothyronine |
CA1028643A (en) * | 1975-02-20 | 1978-03-28 | Judith I. Blakemore | Polylodothyronine immunoassay |
US4341865A (en) * | 1980-07-21 | 1982-07-27 | Abbott Laboratories | Determination of thyroxine binding globulin |
US4378428A (en) * | 1981-03-30 | 1983-03-29 | Baker Instruments Corporation | Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays |
US4614712A (en) * | 1983-02-25 | 1986-09-30 | The Upjohn Company | Immunoassays with luciferase labeled ligands or receptors |
US4708929A (en) * | 1984-10-29 | 1987-11-24 | Microgenics Corporation | Methods for protein binding enzyme complementation assays |
EP0199801B1 (en) * | 1984-10-29 | 1993-08-25 | MICROGENICS CORPORATION (a Delaware corporation) | Methods for protein binding enzyme complementation assays |
DE3504406A1 (de) * | 1985-02-08 | 1986-08-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung der bindungskapazitaet des thyroxin bindenden globulins |
JPS61225655A (ja) * | 1985-03-29 | 1986-10-07 | Eiken Kagaku Kk | 血中遊離型サイロキシンの測定法 |
-
1988
- 1988-09-30 ES ES88309122T patent/ES2055740T3/es not_active Expired - Lifetime
- 1988-09-30 EP EP88309122A patent/EP0310430B1/en not_active Expired - Lifetime
- 1988-09-30 AU AU22993/88A patent/AU618022B2/en not_active Ceased
- 1988-09-30 CA CA000579043A patent/CA1317861C/en not_active Expired - Fee Related
- 1988-09-30 DE DE3889407T patent/DE3889407T2/de not_active Expired - Fee Related
- 1988-09-30 JP JP63244687A patent/JP2579672B2/ja not_active Expired - Fee Related
- 1988-09-30 AT AT8888309122T patent/ATE105414T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0310430A3 (en) | 1990-01-17 |
EP0310430B1 (en) | 1994-05-04 |
ATE105414T1 (de) | 1994-05-15 |
DE3889407T2 (de) | 1994-11-03 |
JPH01257262A (ja) | 1989-10-13 |
AU2299388A (en) | 1989-04-06 |
EP0310430A2 (en) | 1989-04-05 |
CA1317861C (en) | 1993-05-18 |
DE3889407D1 (de) | 1994-06-09 |
AU618022B2 (en) | 1991-12-12 |
JP2579672B2 (ja) | 1997-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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