ES2052492T1 - Aminacion reductiva de un aminoacido o de un derivado de un aminoacido con un alfa-cetoacido o con un derivado de alfa-cetoacido. - Google Patents

Aminacion reductiva de un aminoacido o de un derivado de un aminoacido con un alfa-cetoacido o con un derivado de alfa-cetoacido.

Info

Publication number
ES2052492T1
ES2052492T1 ES92111142T ES92111142T ES2052492T1 ES 2052492 T1 ES2052492 T1 ES 2052492T1 ES 92111142 T ES92111142 T ES 92111142T ES 92111142 T ES92111142 T ES 92111142T ES 2052492 T1 ES2052492 T1 ES 2052492T1
Authority
ES
Spain
Prior art keywords
cetoacide
alpha
derivative
amino acid
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES92111142T
Other languages
English (en)
Other versions
ES2052492T3 (es
Inventor
Matthias Dr Kottenhahn
Horst Harr
Karlheinz Dr Drauz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Publication of ES2052492T1 publication Critical patent/ES2052492T1/es
Application granted granted Critical
Publication of ES2052492T3 publication Critical patent/ES2052492T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

2.1 AMINOACIDOS ORES DE ANGIOTENSING CONVERTING ENZYMES (ACE), REPRESENTANTES DE ELLOS SON POR EJEMPLO EL ENALAPRIL Y RAMIPRIL. ESTOS COMPUESTOS SE PRESENTA A TRAVES DE TRANSFORMACION HIDROGENOLITICA DE UNA AMINA PRIMARIA CON UNA ACETONA, LOS PROCESOS CONOCIDOS SON SIN EMBARGO DIFICILES DE REPRODUCIR Y CONTIENEN EN SU MAYORIA AUN CANTIDAD CONSIDERABLE DE PRODUCTOS PROXIMOS. CON EL NUEVO PROCESO DEBE SER OBTENIDO UN BUEN RENDIMIENTO CON MENOS PRODUCTOS PROXIMOS Y SIN ALTO COSTE ADICIONAL. 2.2 LA TRANSFORMACION HIDROGENOLITICA SE EFECTUA SEGUN LA INVENCION BAJO LA ADICION DE UNA BASE ORGANICA O INORGANICA, DONDE SON PREFERENTES LAS BASES INORGANICAS COMPUESTAS DE OXIDO DE ALUMINIO. A TRAVES DE LA UTILIZACION DE BASES ORGANICAS ES FAVORABLE LA GENERACION DE UN DIASTEREOMERO. 2.3 ACE, REGULADORES DE LA PRESION SANGUINEA.
ES92111142T 1991-07-13 1992-07-01 Aminacion reductora de un aminoacido o de un derivado de aminoacido con un alfa-cetoacido o con un derivado de un alfa-cetoacido. Expired - Lifetime ES2052492T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4123248A DE4123248C2 (de) 1991-07-13 1991-07-13 Verfahren zur Herstellung von N-substituierten alpha-Aminosäuren und alpha-Aminosäure-Derivaten

Publications (2)

Publication Number Publication Date
ES2052492T1 true ES2052492T1 (es) 1994-07-16
ES2052492T3 ES2052492T3 (es) 1996-07-16

Family

ID=6436071

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92111142T Expired - Lifetime ES2052492T3 (es) 1991-07-13 1992-07-01 Aminacion reductora de un aminoacido o de un derivado de aminoacido con un alfa-cetoacido o con un derivado de un alfa-cetoacido.

Country Status (14)

Country Link
US (1) US5387696A (es)
EP (1) EP0523449B1 (es)
JP (1) JP3224422B2 (es)
AT (1) ATE138075T1 (es)
CZ (1) CZ286877B6 (es)
DE (2) DE4123248C2 (es)
DK (1) DK0523449T3 (es)
ES (1) ES2052492T3 (es)
GR (1) GR3020061T3 (es)
HK (1) HK1000209A1 (es)
HU (1) HU213524B (es)
IE (1) IE73437B1 (es)
SG (1) SG48736A1 (es)
SK (1) SK283042B6 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3511519B2 (ja) * 1993-01-08 2004-03-29 鐘淵化学工業株式会社 Ｎ▲２▼−（（ｓ）−１−エトキシカルボニル−３−フェニルプロピル）−ｎ▲６▼−トリフルオロアセチル−ｌ−リシル−ｌ−プロリンの結晶化方法
US5319098A (en) * 1993-05-18 1994-06-07 Celgene Corporation Process for the stereoselective preparation of L-alanyl-L-proline
DE4331540A1 (de) * 1993-09-17 1995-03-23 Degussa Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester)
IT1271687B (it) * 1994-08-04 1997-06-04 Flamma Spa Sali organici idrosolubili della creatina
JPH11512522A (ja) * 1995-09-15 1999-10-26 メルク エンド カンパニー インコーポレーテッド エナラプリル及びエナラプリラトの異性体の分析法
US5907044A (en) 1997-07-30 1999-05-25 Degussa Aktiengellschaft Method of isolating 1- N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl!-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE)
TW533196B (en) * 1998-09-23 2003-05-21 Merck & Co Inc Improved stereoselective process for ENALAPRIL
US6555551B1 (en) 1999-08-31 2003-04-29 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
US20040157911A1 (en) * 1999-08-31 2004-08-12 Spiridon Spireas Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
AR033048A1 (es) * 2001-03-19 2003-12-03 Kaneka Corp Metodo para la purificacion de la n-(1(s)-etoxicarbonil-3-fenilpropil) -l-alanina
US7074959B2 (en) 2002-08-01 2006-07-11 New Mexico Highlands University Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces
US20080103202A1 (en) * 2004-11-08 2008-05-01 Chris Ferguson Method of preparing creatine ester salts and uses thereof.
WO2008132759A2 (en) * 2007-04-27 2008-11-06 Matrix Laboratories Ltd Industrially advantageous process for the production of lisinopril dihydrate
US20150225329A1 (en) 2012-09-14 2015-08-13 Bioamber Inc. Alternative pathways to adipic acid by combined fermentation and catalytic methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU543804B2 (en) * 1980-10-31 1985-05-02 Takeda Chemical Industries Ltd. Amides having bicyclic substituents on nitrogen

Also Published As

Publication number Publication date
CZ286877B6 (cs) 2000-07-12
JPH05201882A (ja) 1993-08-10
EP0523449A2 (de) 1993-01-20
DE4123248A1 (de) 1993-01-14
EP0523449B1 (de) 1996-05-15
SK216692A3 (en) 1994-12-07
DE4123248C2 (de) 1996-03-07
ES2052492T3 (es) 1996-07-16
DK0523449T3 (da) 1996-07-08
CZ216692A3 (en) 1993-02-17
HU9202295D0 (en) 1992-10-28
SK283042B6 (sk) 2003-02-04
GR3020061T3 (en) 1996-08-31
HU213524B (en) 1997-07-28
HUT63634A (en) 1993-09-28
ATE138075T1 (de) 1996-06-15
IE73437B1 (en) 1997-06-04
HK1000209A1 (en) 1998-02-06
JP3224422B2 (ja) 2001-10-29
IE922274A1 (en) 1993-01-13
EP0523449A3 (en) 1993-09-29
US5387696A (en) 1995-02-07
DE59206279D1 (de) 1996-06-20
SG48736A1 (en) 1998-05-18

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