ES2050621B1 - Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas. - Google Patents

Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

Info

Publication number
ES2050621B1
ES2050621B1 ES9202244A ES9202244A ES2050621B1 ES 2050621 B1 ES2050621 B1 ES 2050621B1 ES 9202244 A ES9202244 A ES 9202244A ES 9202244 A ES9202244 A ES 9202244A ES 2050621 B1 ES2050621 B1 ES 2050621B1
Authority
ES
Spain
Prior art keywords
aminopenicillins
preparation
substitute
improved procedure
obtains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9202244A
Other languages
English (en)
Other versions
ES2050621A1 (es
Inventor
Barruelo Oscar Ferrero
Ortiz Juan F Lopez
Alba Alejandro Vitaller
Maldonado Francisco Salto
Elvira Rosa Maria Nieves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SA filed Critical Antibioticos SA
Priority to ES9202244A priority Critical patent/ES2050621B1/es
Publication of ES2050621A1 publication Critical patent/ES2050621A1/es
Application granted granted Critical
Publication of ES2050621B1 publication Critical patent/ES2050621B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

UN PROCEDIMIENTO MEJORADO PARA LA PREPARACION DE 6-AMINOPENICILINAS, PARTICULARMENTE AMPICILINA O AMOXICILINA, EMPLEANDO DISOLVENTES EXENTOS DE ATOMOS DE HALOGENO, QUE COMPRENDE: (A) HACER REACCIONAR UN VINIL AMINOACIDO N-SUSTITUIDO CON UN AGENTE ACILANTE, EN EL SENO DE UN DISOLVENTE AROMATICO, PREFERIBLEMENTE TOLUENO, CON LO QUE SE OBTIENE UN ANHIDRIDO MIXTO; Y (B) HACER REACCIONAR DICHO ANHIDRIDO MIXTO CON UNA SAL DE ACIDO 6-AMINOPENICILANICO (6-APA) EN UN DISOLVENTE ORGANICO, CON LO QUE SE OBTIENEN 6-AMINOPENICILINAS CON UN RENDIMIENTO SUPERIORAL 85% Y UNA PUREZA SUPERIOR AL 98%.
ES9202244A 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas. Expired - Fee Related ES2050621B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202244A ES2050621B1 (es) 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202244A ES2050621B1 (es) 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

Publications (2)

Publication Number Publication Date
ES2050621A1 ES2050621A1 (es) 1994-05-16
ES2050621B1 true ES2050621B1 (es) 1994-12-16

Family

ID=8278702

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202244A Expired - Fee Related ES2050621B1 (es) 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

Country Status (1)

Country Link
ES (1) ES2050621B1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1043957B (it) * 1970-12-31 1980-02-29 Lorenzini Sas Inst Biochim Processo per la preparazione della forma anidra dell acido 6, d, meno alfa aminofenilacetamido penicillanico
YU40474B (en) * 1977-04-04 1986-02-28 Glenika Process for obtaining amoxicillin
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
YU41748B (en) * 1980-11-17 1987-12-31 Pliva Pharm & Chem Works Process for preparing semisynthetic penicilins
HU221200B1 (en) * 1990-01-22 2002-08-28 Biochemie Gmbh Process for producing beta-lactames

Also Published As

Publication number Publication date
ES2050621A1 (es) 1994-05-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051107