ES2050621A1 - Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas. - Google Patents

Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

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Publication number
ES2050621A1
ES2050621A1 ES09202244A ES9202244A ES2050621A1 ES 2050621 A1 ES2050621 A1 ES 2050621A1 ES 09202244 A ES09202244 A ES 09202244A ES 9202244 A ES9202244 A ES 9202244A ES 2050621 A1 ES2050621 A1 ES 2050621A1
Authority
ES
Spain
Prior art keywords
alpha
aminopenicillins
preparation
improved procedure
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09202244A
Other languages
English (en)
Other versions
ES2050621B1 (es
Inventor
Barruelo Oscar Ferrero
Ortiz Juan F Lopez
Alba Alejandro Vitaller
Maldonado Francisco Salto
Elvira Rosa Maria Nieves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SA filed Critical Antibioticos SA
Priority to ES9202244A priority Critical patent/ES2050621B1/es
Publication of ES2050621A1 publication Critical patent/ES2050621A1/es
Application granted granted Critical
Publication of ES2050621B1 publication Critical patent/ES2050621B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

UN PROCEDIMIENTO MEJORADO PARA LA PREPARACION DE 6-AMINOPENICILINAS, PARTICULARMENTE AMPICILINA O AMOXICILINA, EMPLEANDO DISOLVENTES EXENTOS DE ATOMOS DE HALOGENO, QUE COMPRENDE: (A) HACER REACCIONAR UN VINIL AMINOACIDO N-SUSTITUIDO CON UN AGENTE ACILANTE, EN EL SENO DE UN DISOLVENTE AROMATICO, PREFERIBLEMENTE TOLUENO, CON LO QUE SE OBTIENE UN ANHIDRIDO MIXTO; Y (B) HACER REACCIONAR DICHO ANHIDRIDO MIXTO CON UNA SAL DE ACIDO 6-AMINOPENICILANICO (6-APA) EN UN DISOLVENTE ORGANICO, CON LO QUE SE OBTIENEN 6-AMINOPENICILINAS CON UN RENDIMIENTO SUPERIORAL 85% Y UNA PUREZA SUPERIOR AL 98%.
ES9202244A 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas. Expired - Fee Related ES2050621B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202244A ES2050621B1 (es) 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202244A ES2050621B1 (es) 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

Publications (2)

Publication Number Publication Date
ES2050621A1 true ES2050621A1 (es) 1994-05-16
ES2050621B1 ES2050621B1 (es) 1994-12-16

Family

ID=8278702

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202244A Expired - Fee Related ES2050621B1 (es) 1992-11-06 1992-11-06 Un procedimiento mejorado para la preparacion de 6-*-aminopenicilinas.

Country Status (1)

Country Link
ES (1) ES2050621B1 (es)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2120150A1 (en) * 1970-12-31 1972-08-11 Istituto Biochimico Italiano Anhydrous ampicillin prepn - without isolation of hydrated ampicillin
US4128547A (en) * 1977-09-06 1978-12-05 Gist-Brocades N.V. 6-(D-α-Amino-p-hydroxyphenylacetamido)-penicillanic acid preparation
GB1594997A (en) * 1977-04-04 1981-08-05 Galenika Pharmaceutical Process for the preparation of amoxicillin
GB2087871A (en) * 1980-11-17 1982-06-03 Pliva Pharm & Chem Works Manufacture of semisynthetic penicillins
EP0439096A2 (en) * 1990-01-22 1991-07-31 Biochemie Gesellschaft M.B.H. Improvements in or relating to beta lactam production

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2120150A1 (en) * 1970-12-31 1972-08-11 Istituto Biochimico Italiano Anhydrous ampicillin prepn - without isolation of hydrated ampicillin
GB1594997A (en) * 1977-04-04 1981-08-05 Galenika Pharmaceutical Process for the preparation of amoxicillin
US4128547A (en) * 1977-09-06 1978-12-05 Gist-Brocades N.V. 6-(D-α-Amino-p-hydroxyphenylacetamido)-penicillanic acid preparation
GB2087871A (en) * 1980-11-17 1982-06-03 Pliva Pharm & Chem Works Manufacture of semisynthetic penicillins
EP0439096A2 (en) * 1990-01-22 1991-07-31 Biochemie Gesellschaft M.B.H. Improvements in or relating to beta lactam production

Also Published As

Publication number Publication date
ES2050621B1 (es) 1994-12-16

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Legal Events

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FD1A Patent lapsed

Effective date: 20051107