ES2044087T3 - Un metodo para preparar una composicion de 13,14-dihidro-15-cetoprostaglandina estabilizada. - Google Patents
Un metodo para preparar una composicion de 13,14-dihidro-15-cetoprostaglandina estabilizada.Info
- Publication number
- ES2044087T3 ES2044087T3 ES89301888T ES89301888T ES2044087T3 ES 2044087 T3 ES2044087 T3 ES 2044087T3 ES 89301888 T ES89301888 T ES 89301888T ES 89301888 T ES89301888 T ES 89301888T ES 2044087 T3 ES2044087 T3 ES 2044087T3
- Authority
- ES
- Spain
- Prior art keywords
- dihydro
- stabilized
- composition
- cetoprostaglandine
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000000258 13,14-dihydro-15-keto-prostaglandin D2 derivatives Chemical class 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- 239000011872 intimate mixture Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN COMPUESTO ESTABLE DE 13,14 - DIHIDRO - 15 - CETOPROSTAGLANDINA QUE TIENE UNA MEZCLA INTIMA DE A) UNA CANTIDAD EFECTIVA TERAPEUTICAMENTE DE AL MENOS UN COMPUESTO SELECCIONADO DE 13, 14 DIHIDRO - 15 - CETOPOROSFAGLANDINAS; Y B) AL MENOS UN COMPUESTO SELECCIONADO DE CICLODEXTRINAS ESTERIZADAS ACEPTABLES FARMACEUTICAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63045622A JP2597629B2 (ja) | 1988-02-26 | 1988-02-26 | 13,14−ジヒドロ−15−ケトプロスタグランジン類の安定化 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2044087T3 true ES2044087T3 (es) | 1994-01-01 |
Family
ID=12724473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89301888T Expired - Lifetime ES2044087T3 (es) | 1988-02-26 | 1989-02-24 | Un metodo para preparar una composicion de 13,14-dihidro-15-cetoprostaglandina estabilizada. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0330511B1 (es) |
JP (1) | JP2597629B2 (es) |
KR (1) | KR970005170B1 (es) |
AT (1) | ATE79260T1 (es) |
AU (1) | AU612791B2 (es) |
CA (1) | CA1314483C (es) |
DE (1) | DE68902401T2 (es) |
ES (1) | ES2044087T3 (es) |
GB (1) | GB2216004A (es) |
GR (1) | GR3005933T3 (es) |
NZ (1) | NZ228111A (es) |
OA (1) | OA09236A (es) |
ZA (1) | ZA891410B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6420422B1 (en) | 1987-09-18 | 2002-07-16 | Sucampo Pharmaceuticals, Inc. | Ocular hypotensive agents |
US5212200A (en) * | 1987-09-18 | 1993-05-18 | R-Tech Ueno, Ltd. | Ocular hypotensive agents |
US5236907A (en) * | 1988-10-01 | 1993-08-17 | R-Tech Ueno Ltd. | Ocular hypotensive agents |
US5166178B1 (en) * | 1987-09-18 | 1998-07-21 | R Tech Ueno Ltd | Ocular hypotensive agents |
ES2052735T3 (es) * | 1987-09-18 | 1994-07-16 | R Tech Ueno Ltd | Un metodo para producir un agente hipotensor ocular. |
US5565492A (en) * | 1988-07-18 | 1996-10-15 | Alcon Laboratories, Inc. | Prostaglandin combinations in glaucoma therapy |
ATE101342T1 (de) * | 1988-09-06 | 1994-02-15 | Kabi Pharmacia Ab | Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension. |
ATE111736T1 (de) * | 1988-10-01 | 1994-10-15 | R Tech Ueno Ltd | Okulare hypotensive mittel. |
US5194429A (en) * | 1988-10-01 | 1993-03-16 | K.K. Ueno Seiyaku Oyo Kenkyujo | Ocular hypotensive agents |
US5234954A (en) * | 1989-07-27 | 1993-08-10 | K.K. Ueno Seiyaku Oyo Kenkyujo | Treatment of hyperlipidemia with 15-keto-prostaglandin compounds |
ATE122563T1 (de) * | 1989-07-27 | 1995-06-15 | Ueno Seiyaku Oyo Kenkyujo Kk | Verwendung von 15-keto-prostansäure-derivaten zur herstellung eines medikaments für die verbesserung der ausscheidung des kaliumions. |
CA2022372C (en) * | 1989-08-09 | 2000-05-02 | Ryuji Ueno | Improvement of excretion of nonprotein nitrogen into the intestine by prostanoic acid derivatives |
CA2027814C (en) * | 1989-10-20 | 1996-07-30 | Ryuji Ueno | Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds |
CA2030346C (en) * | 1989-11-22 | 2000-04-11 | Ryuji Ueno | Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds |
US5256696A (en) * | 1989-11-22 | 1993-10-26 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds |
CA2030344C (en) * | 1989-11-22 | 2000-04-18 | Ryuji Ueno | Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds |
US5254588A (en) * | 1989-11-22 | 1993-10-19 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds |
CA2031469A1 (en) * | 1989-12-28 | 1991-06-29 | Larry A. Wheeler | Use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension |
TW224942B (es) * | 1990-04-04 | 1994-06-11 | Adka Ueno Kk | |
CA2046069C (en) * | 1990-07-10 | 2002-04-09 | Ryuji Ueno | Treatment of inflammatory diseases with 15-keto-prostaglandin compounds |
DE69213057T2 (de) * | 1991-03-14 | 1997-01-09 | Ueno Seiyaku Oyo Kenkyujo Kk | Stimulierung von Wundheilung mit 15-Keto-prostaglandinverbindungen |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
US6184250B1 (en) | 1993-08-03 | 2001-02-06 | Alcon Laboratories, Inc. | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension |
US5698733A (en) * | 1994-09-30 | 1997-12-16 | Alcon Laboratories, Inc. | Use of 9-deoxy prostaglandin derivatives to treat glaucoma |
US5807892A (en) * | 1994-09-30 | 1998-09-15 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US6169111B1 (en) | 1995-06-07 | 2001-01-02 | Alcon Laboratories, Inc. | Conformationally rigid aryl prostaglandins for use in glaucoma therapy |
US6096783A (en) * | 1998-12-15 | 2000-08-01 | Alcon Laboratories, Inc. | Cyclobutane prostaglandin analogues as ocular hypotensive agents |
US6211226B1 (en) | 1998-12-17 | 2001-04-03 | Alcon Laboratories, Inc. | 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
CA2502439C (en) | 2002-10-23 | 2011-11-22 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
US20080139652A1 (en) | 2003-11-07 | 2008-06-12 | Yusuke Sakai | Pharmaceutical Composition Containing Prostaglandin |
EP1985298A1 (en) | 2007-04-24 | 2008-10-29 | Azad Pharma AG | Ophtalmic oil-in-water emulsions containing prostaglandins |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5910525A (ja) * | 1982-06-21 | 1984-01-20 | Teisan Seiyaku Kk | プロスタグランジンeの安定化組成物 |
JPH0819004B2 (ja) * | 1986-12-26 | 1996-02-28 | 日清製粉株式会社 | 徐放性医薬製剤 |
CA1323364C (en) | 1987-01-28 | 1993-10-19 | Ryuzo Ueno | Prostaglandins e and anti ulcer agents containing same |
CA1322749C (en) | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
CA1324129C (en) | 1987-04-30 | 1993-11-09 | Ryuzo Ueno | Prostaglandins of the f series |
ES2038289T3 (es) | 1987-05-15 | 1993-07-16 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Utilizacion de 15-ceto-pges para la fabricacion de un medicamento para aumentar la temperatura corporal. |
ES2052735T3 (es) | 1987-09-18 | 1994-07-16 | R Tech Ueno Ltd | Un metodo para producir un agente hipotensor ocular. |
-
1988
- 1988-02-26 JP JP63045622A patent/JP2597629B2/ja not_active Expired - Fee Related
-
1989
- 1989-02-23 ZA ZA891410A patent/ZA891410B/xx unknown
- 1989-02-23 CA CA000591913A patent/CA1314483C/en not_active Expired - Fee Related
- 1989-02-23 NZ NZ228111A patent/NZ228111A/xx unknown
- 1989-02-23 AU AU30298/89A patent/AU612791B2/en not_active Ceased
- 1989-02-24 GB GB8904232A patent/GB2216004A/en not_active Withdrawn
- 1989-02-24 DE DE8989301888T patent/DE68902401T2/de not_active Expired - Lifetime
- 1989-02-24 EP EP89301888A patent/EP0330511B1/en not_active Expired - Lifetime
- 1989-02-24 ES ES89301888T patent/ES2044087T3/es not_active Expired - Lifetime
- 1989-02-24 AT AT89301888T patent/ATE79260T1/de not_active IP Right Cessation
- 1989-02-24 OA OA59533A patent/OA09236A/xx unknown
- 1989-02-25 KR KR89002257A patent/KR970005170B1/ko not_active IP Right Cessation
-
1992
- 1992-10-12 GR GR920402253T patent/GR3005933T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GB2216004A (en) | 1989-10-04 |
JP2597629B2 (ja) | 1997-04-09 |
ZA891410B (en) | 1989-11-29 |
EP0330511A3 (en) | 1989-10-18 |
AU612791B2 (en) | 1991-07-18 |
KR970005170B1 (en) | 1997-04-14 |
ATE79260T1 (de) | 1992-08-15 |
AU3029889A (en) | 1989-08-31 |
DE68902401T2 (de) | 1992-12-10 |
KR890012654A (ko) | 1989-09-18 |
EP0330511A2 (en) | 1989-08-30 |
OA09236A (en) | 1992-06-30 |
JPH01221317A (ja) | 1989-09-04 |
GR3005933T3 (es) | 1993-06-07 |
EP0330511B1 (en) | 1992-08-12 |
DE68902401D1 (de) | 1992-09-17 |
GB8904232D0 (en) | 1989-04-12 |
CA1314483C (en) | 1993-03-16 |
NZ228111A (en) | 1991-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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