ES2004097A6 - Procedimiento de preparacion de un nuevo derivado triciclico denominado acido 5-(3-cloro-6-metil-5,5-dioxo-6,11-dihidro-(c,f)-dibenzo-(1,2)-tiazepin-11-il)amino)-pentanoico - Google Patents

Procedimiento de preparacion de un nuevo derivado triciclico denominado acido 5-(3-cloro-6-metil-5,5-dioxo-6,11-dihidro-(c,f)-dibenzo-(1,2)-tiazepin-11-il)amino)-pentanoico

Info

Publication number
ES2004097A6
ES2004097A6 ES8700429A ES8700429A ES2004097A6 ES 2004097 A6 ES2004097 A6 ES 2004097A6 ES 8700429 A ES8700429 A ES 8700429A ES 8700429 A ES8700429 A ES 8700429A ES 2004097 A6 ES2004097 A6 ES 2004097A6
Authority
ES
Spain
Prior art keywords
medicines
thiazepin
dibenzo
dioxo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8700429A
Other languages
English (en)
Inventor
Charles Malen
Poignant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES2004097A6 publication Critical patent/ES2004097A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

EL PROCEDIMIENTO SE CARACTERIZA POR LA CONDENSACION DE UN DERIVADO 11-CLORO O 11-BROMO DE LA REFERIDA DIBENZOTIAZEPINA CON UN ESTER DEL ACIDO 5-AMINO-PENTANOICO, SEGUIDA DE SAPONIFICACION PARA RENDIR EL ACIDO DEL TITULO. LOS COMPUESTOS PREPARADOS SEGUN EL PROCEDIMIENTO DESCRITO POSEEN IMPORTANTES EFECTOS ANTIDEPRESIVOS. 1. PROCEDIMIENTO DE PREPARACION DEL COMPUESTO DE FORMULA I EN FORMA RACEMICA O DE ISOMEROS OPTICOS Y SUS SALES DE ADICION A UNA BASE ORGANICA O MINERAL O A UN ACIDO MINERAL U ORGANICA FARMACEUTICAMENTE ACEPTABLE, CARACTERIZADO POR CONDENSARSE UN DERIVADO HALOGENADO DE FORMULA GENERAL II EN LA QUE X REPRESENTA UN ATOMO DE CLORO O DE BROMO, CON UN ESTER DE ACIDO 5-AMINO-PENTANOICO DE FORMULA GENERAL III, EN LA QUE R REPRESENTA UN RADICAL ALQUILO INFERIOR QUE CONTIENE DE 1 A 4 ATOMOS DE CARBONO, EN FORMA DE BASE O DE UNZ DE SUS SALES DE ADICION CON UN ACIDO MINERAL U ORGANICO.
ES8700429A 1986-02-21 1987-02-19 Procedimiento de preparacion de un nuevo derivado triciclico denominado acido 5-(3-cloro-6-metil-5,5-dioxo-6,11-dihidro-(c,f)-dibenzo-(1,2)-tiazepin-11-il)amino)-pentanoico Expired ES2004097A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8602399A FR2594827B1 (fr) 1986-02-21 1986-02-21 Nouveau derive tricyclique denomme acide ((chloro-3 methyl-6 dioxo-5,5 dihydro-6, 11 dibenzo (c,f) thiazepine (1,2) yl-11 amino)-5 pentazoique, son procede de preparation et les compositions pharmaceutiques qui le contiennent

Publications (1)

Publication Number Publication Date
ES2004097A6 true ES2004097A6 (es) 1988-12-01

Family

ID=9332386

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8700429A Expired ES2004097A6 (es) 1986-02-21 1987-02-19 Procedimiento de preparacion de un nuevo derivado triciclico denominado acido 5-(3-cloro-6-metil-5,5-dioxo-6,11-dihidro-(c,f)-dibenzo-(1,2)-tiazepin-11-il)amino)-pentanoico

Country Status (12)

Country Link
US (1) US4766114A (es)
EP (1) EP0239436B1 (es)
JP (1) JPS62198672A (es)
AT (1) ATE53995T1 (es)
CA (1) CA1282781C (es)
DE (1) DE3763311D1 (es)
DK (1) DK88087A (es)
ES (1) ES2004097A6 (es)
FR (1) FR2594827B1 (es)
GR (1) GR870285B (es)
IE (1) IE59468B1 (es)
PT (1) PT84332B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2040629B1 (es) * 1991-12-18 1994-06-16 Consejo Superior Investigacion Procedimiento de obtencion de derivados triciclicos de la benzotiazepina farmacologicamente activos.
US5716949A (en) * 1995-04-07 1998-02-10 Novo Nordisk A/S Heterocyclic compounds
US6683072B1 (en) 2003-02-04 2004-01-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia
US20050227961A1 (en) * 2004-04-08 2005-10-13 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of neuropathic pain, fibromyalgia and chronic fatigue syndrome
TWI436988B (zh) * 2007-03-05 2014-05-11 Transform Pharmaceuticals Inc ７-〔（３-氯-６，１１-二氫-６-甲基二苯并〔ｃ，ｆ〕〔１，２〕噻氮呯-１１-基）胺〕庚酸ｓ，ｓ二氧化物之多晶型及其製造與使用方法
US9314469B2 (en) 2008-05-05 2016-04-19 Tonix Pharma Holdings Limited Method for treating neurocognitive dysfunction
GB201208315D0 (en) 2012-05-11 2012-06-27 Numedicus Ltd Pharmaceutical methods and compositions
JP6557674B2 (ja) * 2014-03-12 2019-08-07 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 新規クラスのミュー−オピオイド受容体アゴニスト
WO2017049158A1 (en) 2015-09-16 2017-03-23 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
US20230365519A1 (en) * 2020-10-06 2023-11-16 Kures, Inc. Carboxylic diarylthiazepineamines and uses thereof
US20240092802A1 (en) * 2020-10-06 2024-03-21 Kures, Inc. Mu-opioid receptor agonists and uses therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1269551A (en) * 1969-03-27 1972-04-06 Science Union & Cie New tricyclic derivatives and process for their manufacture
US3821249A (en) * 1970-03-13 1974-06-28 En Nom Collectif Science Union Dibenzothiazefin derivatives

Also Published As

Publication number Publication date
PT84332A (fr) 1987-03-01
JPS62198672A (ja) 1987-09-02
CA1282781C (fr) 1991-04-09
DE3763311D1 (de) 1990-07-26
GR870285B (en) 1987-06-30
DK88087D0 (da) 1987-02-20
US4766114A (en) 1988-08-23
JPH0378858B2 (es) 1991-12-17
EP0239436B1 (fr) 1990-06-20
FR2594827A1 (fr) 1987-08-28
IE59468B1 (en) 1994-03-09
PT84332B (pt) 1989-09-14
DK88087A (da) 1987-08-22
IE870427L (en) 1987-08-21
EP0239436A1 (fr) 1987-09-30
FR2594827B1 (fr) 1988-05-20
ATE53995T1 (de) 1990-07-15

Similar Documents

Publication Publication Date Title
AU2411588A (en) Improved process for the manufacture of 1,1,1- trifluorodichloroethane and 1,1,1,2-tetrafluorochloroethane
EP0302020A3 (en) Process for the preparation of 2,2,6,6-tetramethyl-4-piperidyl-amines
GR3005035T3 (es)
GR3014958T3 (en) 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds.
IL84446A0 (en) 3-pyrrolidinylthio-1-azabicyclo-(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU2705588A (en) New ciclosporin crystal form, processes for its production, pharmaceutical compositions containing it and its use.
HU913216D0 (en) Process for the production of saturated hydroxy-alkyl-kinoline acids, and of medical preparations containing them
HUT47103A (en) Process for producing 1,4-benzoxazine derivatives and pharmaceutical compositions comprising the same
ES2004097A6 (es) Procedimiento de preparacion de un nuevo derivado triciclico denominado acido 5-(3-cloro-6-metil-5,5-dioxo-6,11-dihidro-(c,f)-dibenzo-(1,2)-tiazepin-11-il)amino)-pentanoico
GR3001619T3 (en) Process for the preparation of (2,2)-paracyclophane
AR243180A1 (es) Procedimiento para la obtencion de 3,4-dihidro-2h-benzopiranos sustituidos.
HU901428D0 (en) Process for the preparation of 5-substituted 1,4-dihydro-4-oxo-naphthiridine-3-carboxylic acid derivatives
ZA897541B (en) Benzoxazolinone derivatives,process for the preparation thereof and pharmaceutical compositions containing them
EP0278452A3 (en) 2,4- and 2,5-pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds
GB2205830B (en) Process for the preparation of 1,2,5,6,9,10-hexabromocyclododecane
EP0264744A3 (en) Process for the preparation of 4,4'-diaminodiphenylmethane and its derivatives.
DK0719276T3 (da) Ïstradiolestre med stærk oral virkning samt farmaceutiske præparater med indhold deraf
IL86646A (en) Process for the preparation of 5,11-di-and 5,6,11,12-tetraphenylnaphthacenes
DE69104608D1 (de) Pharmazeutische Zubereitungen, Clavulansäure enthaltend, für die Behandlung der Periodontitis.
EP0438641A3 (en) Process for preparing 2,6-di-tert.butylphenol
IL82294A0 (en) 1,3-dihydropyridine derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
HU9201117D0 (en) Substituted 2',3'-didezoxy-5-trifluor-methyl-uridine, and process for the production of medical preparations containing such compounds
HUT51626A (en) Process for producing 5-substituted amino-8-phenyl or substituted phenyl-3h,6h-1,4,5a,8a-tetraaza-ceanaphthylene-3-ones and pharmaceutical preparations containing these compounds
YU91779A (en) Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5h-dibenzo (b,f,)azepine-5-carboxamide into 10-oxo-10,11-dihydro-5h-dibenzo(b,f)azepine-5-carboxamide
AU4720889A (en) Process for the preparation of 1,1-dichloro-1-fluoroethane

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405