ES2039360T3 - Tetrahidro-beta-carbolinas, procedimiento para su preparacion y su utilizacion como medicamentos. - Google Patents
Tetrahidro-beta-carbolinas, procedimiento para su preparacion y su utilizacion como medicamentos.Info
- Publication number
- ES2039360T3 ES2039360T3 ES198686730154T ES86730154T ES2039360T3 ES 2039360 T3 ES2039360 T3 ES 2039360T3 ES 198686730154 T ES198686730154 T ES 198686730154T ES 86730154 T ES86730154 T ES 86730154T ES 2039360 T3 ES2039360 T3 ES 2039360T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- beta
- hydrogen
- carbolinas
- tetrahidro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Eyeglasses (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE DESCRIBEN DERIVADOS DE 5, 6, 7, 8 TETRAHIDRO-BETA-CARBOLINA DE FORMULA GENERAL FIGXX EN LA QUE R1 ES UN GRUPO OXIDIAZOLILO DE FORMULA FIGXX EN LA QUE R2 REPRESENTA H, UN GRUPO ALQUILO O CICLOALQUILO INFERIOR, Y UN GRUPO COOR3 EN EL QUE R3 REPRESENTA UN H O UN GRUPO ALQUILO INFERIOR Y UN GRUPO CONR4R5 EN EL QUE R4 Y R5 REPRESENTAN H, O BIEN UN GRUPO ALQUILO O HIDROXIALQUILO INFERIOR, NO PUDIENDO SER AMBOS A LA VEZ H, O BIEN, R4 Y R5 FORMAN CON EL ATOMO DE NITROGENO VECINO UN ANILLO DE 5 O 6 ATOMOS QUE PUEDE CONTENER ADEMAS UN HETEROATOMO, Y RA REPRESENTA H,=0, CICLOALQUILO, -COOR3, EN EL QUE R3 REPRESENTA LO INDICADO ANTERIORMENTE, O BIEN, UN GRUPO ALQUILO INFERIOR QUE PUEDE ESTAR SUSTITUIDO CON OH, HALOGENOS, GRUPOS ALCOXI, FENILO Y FENOXI INFERIORES, O BIEN, _NR4R5 EN EL QUE R4 Y R5 REPRESENTAN LO INDICADO ANTERIORMENTE. RB PUEDE SER H, O UN GRUPO ALQUILO O ALCOXIALQUILO INFERIOR. ESTOS COMPUESTOS PRESENTAN VALIOSAS PROPIEDADES FARMACEUTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853535928 DE3535928A1 (de) | 1985-10-04 | 1985-10-04 | Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2039360T3 true ES2039360T3 (es) | 1993-10-01 |
Family
ID=6283083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198686730154T Expired - Lifetime ES2039360T3 (es) | 1985-10-04 | 1986-10-03 | Tetrahidro-beta-carbolinas, procedimiento para su preparacion y su utilizacion como medicamentos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4855295A (es) |
EP (1) | EP0217737B1 (es) |
JP (1) | JPH0759580B2 (es) |
AT (1) | ATE66226T1 (es) |
AU (1) | AU593024B2 (es) |
CA (1) | CA1269981A (es) |
DE (2) | DE3535928A1 (es) |
DK (1) | DK169581B1 (es) |
ES (1) | ES2039360T3 (es) |
FI (1) | FI864018A (es) |
GR (1) | GR3002944T3 (es) |
HU (1) | HU195814B (es) |
IE (1) | IE58896B1 (es) |
IL (1) | IL80215A0 (es) |
NO (1) | NO164354C (es) |
ZA (1) | ZA867616B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0552237T3 (da) * | 1990-10-09 | 1993-07-28 | Neurogen Corp | Visse cycloalkyl- og azacycloalkyl-pyrrolopyrimidiner, en klasse af ligander for GABA-receptorer i hjernen |
FR2677024B1 (fr) * | 1991-05-29 | 1995-03-03 | Centre Nat Rech Scient | Composes derives des aza-6-indoles, ligands du recepteur des benzodiazepines et medicaments les contenant. |
US5367077A (en) * | 1992-04-08 | 1994-11-22 | Neurogen Corporation | Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands |
AU664912B2 (en) * | 1992-09-02 | 1995-12-07 | Dainippon Pharmaceutical Co. Ltd. | Novel 3-oxadiazolyl-1,6-naphthyridine derivatives |
DE4308788A1 (de) * | 1993-03-18 | 1994-09-22 | Bayer Ag | Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate |
CA2140722A1 (en) * | 1994-01-24 | 1995-07-25 | Joseph A. Jakubowski | Beta-carboline thromboxane synthase inhibitors |
US5550118A (en) * | 1994-01-31 | 1996-08-27 | Eli Lilly And Company | Polyhydronorharman synthase inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES273769A1 (es) * | 1961-01-18 | 1962-06-01 | Geigy Ag J R | Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico |
NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
DE3240511A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von ss-carbolinderivaten |
DE3240513A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung |
DK149270C (da) * | 1983-05-27 | 1986-08-25 | Schering Ag | Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater |
DK240084D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | New beta-carboline-3-oxadiazolyl derivatives |
-
1985
- 1985-10-04 DE DE19853535928 patent/DE3535928A1/de not_active Withdrawn
-
1986
- 1986-10-02 IL IL80215A patent/IL80215A0/xx not_active IP Right Cessation
- 1986-10-02 DK DK471686A patent/DK169581B1/da active
- 1986-10-03 HU HU864182A patent/HU195814B/hu not_active IP Right Cessation
- 1986-10-03 ES ES198686730154T patent/ES2039360T3/es not_active Expired - Lifetime
- 1986-10-03 NO NO863962A patent/NO164354C/no unknown
- 1986-10-03 JP JP61234694A patent/JPH0759580B2/ja not_active Expired - Lifetime
- 1986-10-03 DE DE8686730154T patent/DE3680850D1/de not_active Expired - Lifetime
- 1986-10-03 AT AT86730154T patent/ATE66226T1/de not_active IP Right Cessation
- 1986-10-03 FI FI864018A patent/FI864018A/fi not_active Application Discontinuation
- 1986-10-03 EP EP86730154A patent/EP0217737B1/de not_active Expired - Lifetime
- 1986-10-06 CA CA000519910A patent/CA1269981A/en not_active Expired - Lifetime
- 1986-10-06 US US06/915,357 patent/US4855295A/en not_active Expired - Fee Related
- 1986-10-06 IE IE262986A patent/IE58896B1/en not_active IP Right Cessation
- 1986-10-06 ZA ZA867616A patent/ZA867616B/xx unknown
- 1986-10-07 AU AU63662/86A patent/AU593024B2/en not_active Ceased
-
1991
- 1991-10-18 GR GR91401328T patent/GR3002944T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0217737A3 (en) | 1988-06-01 |
JPS62181278A (ja) | 1987-08-08 |
NO164354C (no) | 1990-09-26 |
NO863962L (no) | 1987-04-06 |
GR3002944T3 (en) | 1993-01-25 |
ATE66226T1 (de) | 1991-08-15 |
ZA867616B (en) | 1987-05-27 |
DK471686A (da) | 1987-04-05 |
DK169581B1 (da) | 1994-12-12 |
FI864018A0 (fi) | 1986-10-03 |
EP0217737B1 (de) | 1991-08-14 |
DE3680850D1 (de) | 1991-09-19 |
AU593024B2 (en) | 1990-02-01 |
US4855295A (en) | 1989-08-08 |
DE3535928A1 (de) | 1987-04-09 |
FI864018A (fi) | 1987-04-05 |
HUT42091A (en) | 1987-06-29 |
JPH0759580B2 (ja) | 1995-06-28 |
DK471686D0 (da) | 1986-10-02 |
NO164354B (no) | 1990-06-18 |
AU6366286A (en) | 1987-04-09 |
HU195814B (en) | 1988-07-28 |
CA1269981A (en) | 1990-06-05 |
EP0217737A2 (de) | 1987-04-08 |
IE58896B1 (en) | 1993-12-01 |
IL80215A0 (en) | 1987-01-30 |
NO863962D0 (no) | 1986-10-03 |
IE862629L (en) | 1987-04-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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