ES2037105T3 - Un metodo para preparar indoloquinoxalinas sustituidas. - Google Patents

Un metodo para preparar indoloquinoxalinas sustituidas.

Info

Publication number
ES2037105T3
ES2037105T3 ES198787850012T ES87850012T ES2037105T3 ES 2037105 T3 ES2037105 T3 ES 2037105T3 ES 198787850012 T ES198787850012 T ES 198787850012T ES 87850012 T ES87850012 T ES 87850012T ES 2037105 T3 ES2037105 T3 ES 2037105T3
Authority
ES
Spain
Prior art keywords
halogen
alkyl
compounds
iodine
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787850012T
Other languages
English (en)
Inventor
Jan Olof Einar Bergman
Stig Gustaf Akerfeldt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2037105T3 publication Critical patent/ES2037105T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A INDOLQUINOXALINAS DE FORMULA GENERAL (I): EN LA QUE R1 REPRESENTA UNO O VARIOS SUSTITUYENTES SIMILARES O DIFERENTES PREFERIBLEMENTE DE 1 A 4, EN LAS POSICIONES 1-4 Y/O 7-10 SELECCIONADAS DE HALOGENO, ALQUILO/ALCOXI DE HASTA 4C, TRIFLUORMETILO O TRICLOROMETILO; X ES UN GRUPO -(CH2)N-R2, EN QUE R2 REPRESENTA UN RESTO BASICO NITROGENADO COMO NH2, NHR4 O NR5R6, SIENDO R4,R5 Y R6 INDEPENDIENTEMENTE ALQUILO DE CADENA CORTA O CICLOALQUILO Y N ES UN ENTERO DE 1 A 4; R3 REPRESENTA H, UN GRUPO ALQUILO/CICLOALQUILO DE HASTA 4C. TAMBIEN SE REFIERE A LOS PRODUCTOS DE ADICION FISIOLOGICAMENTE ACEPTABLES DE COMPUESTOS DE ACIDOS Y ADUCTOS DE HALOGENO, EN ESPECIAL YODO Y MONOCLORURO O MONOBROMURO DE YODO. TAMBIEN SE INDICAN METODOS PARA PREPARAR ESOS COMPUESTOS POR REACCION DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO REACTIVO QUE CONTIENE EL RESIDUO -CHR3X, O MEDIANTE TRANSPOSICION POR CALENTAMIENTO DE UN COMPUESTO DE FORMULA (III). LAS NUEVAS INDOLQUINOXALINAS TIENEN EFECTO ANTIVIRIASICO Y SON ACTIVAS FRENTE AL CANCER.
ES198787850012T 1986-01-21 1987-01-19 Un metodo para preparar indoloquinoxalinas sustituidas. Expired - Lifetime ES2037105T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8600260A SE8600260D0 (sv) 1986-01-21 1986-01-21 Substituerade indolokinoxaliner

Publications (1)

Publication Number Publication Date
ES2037105T3 true ES2037105T3 (es) 1993-06-16

Family

ID=20363170

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787850012T Expired - Lifetime ES2037105T3 (es) 1986-01-21 1987-01-19 Un metodo para preparar indoloquinoxalinas sustituidas.

Country Status (19)

Country Link
US (1) US4990510A (es)
EP (1) EP0238459B1 (es)
JP (1) JPH07107066B2 (es)
KR (1) KR880700801A (es)
AP (1) AP27A (es)
AT (1) ATE74920T1 (es)
AU (1) AU606047B2 (es)
CA (1) CA1303613C (es)
DE (1) DE3778190D1 (es)
DK (1) DK492587D0 (es)
ES (1) ES2037105T3 (es)
FI (1) FI883373A0 (es)
HU (1) HU201937B (es)
IL (1) IL81209A (es)
NO (1) NO873945L (es)
OA (1) OA08744A (es)
RU (1) RU1776259C (es)
SE (1) SE8600260D0 (es)
WO (1) WO1987004436A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8600261D0 (sv) * 1986-01-21 1986-01-21 Lundblad Leif Indolokinoxaliner med substituenter i 6-position som innehaller cykliska grupper
CA2160769A1 (en) * 1993-04-22 1994-10-27 Taro Matsumoto Indolo[2,3-b]quinoxaline derivatives
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
SE504289C2 (sv) * 1994-06-23 1996-12-23 Leif J I Lundblad Användning av vissa indolo-2,3b-kinoxaliner för framställning av ett läkemedel för inhibering av enzymet HIV-integras
SE504862C2 (sv) * 1994-12-27 1997-05-20 Leif J I Lundblad Användning av vissa indolo-§2,3b¤-kinoxaliner för framställning av ett läkemedel för skydd av DNA i initieringsfasen och/eller promotionsfasen av karcinogenes och för förhindrande av oxidativ stress i patienter med sjukdomar relaterade till fria radikaler
US5721277A (en) * 1995-04-21 1998-02-24 Sugen, Inc. Compounds and methods for inhibiting hyper-proliferative cell growth
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
US6465466B1 (en) 1995-12-22 2002-10-15 Leif J. I. Lundblad Uses of indolo-2 [2,3b] -quinoxalines
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
SE9704723D0 (sv) * 1997-12-17 1997-12-17 Leif J I Lundblad Ligands
US6333327B2 (en) * 2000-02-18 2001-12-25 Leif J. I. Lundblad Method for the treatment of Multiple Sclerosis
SE516067C2 (sv) * 2000-02-18 2001-11-12 Lundblad Leif J I Användning av en förening för framställning av ett läkemedel
GB0022922D0 (en) * 2000-09-19 2000-11-01 Chapman Robert E Compounds for use in medicine
SE529777C2 (sv) * 2006-01-23 2007-11-20 Vironova Ab Nya föreningar och användning därav
ATE473977T1 (de) 2008-04-30 2010-07-15 Univ Duisburg Essen Indolä2,3-bü-, indenä1,2-bü- und indenä2,1- büpyridoä2,3-fü quinoxalin-3-carboxylsäuren und ester, verfahren zu ihrer herstellung und ihre verwendung als antivirus- und antitumormittel
EP2489354A1 (en) 2011-02-18 2012-08-22 Vironova AB Pharmaceutical formulation of B220 for topical treatment of herpes
CN105061432B (zh) * 2015-07-16 2017-09-29 河北大学 6H‑吲哚[2,3‑b]喹喔啉衍生物、药物组合物及其制备和应用
WO2022002898A1 (en) * 2020-06-29 2022-01-06 Vironova Medical Ab 6h-indolo(2,3-b)quinoxaline derivatives useful in therapy in particular in a virus infection
EP4171561A1 (en) * 2020-06-29 2023-05-03 Vironova Medical AB 6h-indolo[2,3-b]quinoxaline derivatives useful in therapy

Also Published As

Publication number Publication date
FI883373A (fi) 1988-07-15
OA08744A (en) 1989-03-31
KR880700801A (ko) 1988-04-12
EP0238459B1 (en) 1992-04-15
DK492587A (da) 1987-09-18
AU6899587A (en) 1987-08-14
CA1303613C (en) 1992-06-16
DE3778190D1 (de) 1992-05-21
IL81209A (en) 1991-04-15
IL81209A0 (en) 1987-08-31
EP0238459A1 (en) 1987-09-23
RU1776259C (ru) 1992-11-15
US4990510A (en) 1991-02-05
FI883373A0 (fi) 1988-07-15
NO873945D0 (no) 1987-09-21
AP27A (en) 1988-12-02
ATE74920T1 (de) 1992-05-15
NO873945L (no) 1987-09-21
HU201937B (en) 1991-01-28
SE8600260D0 (sv) 1986-01-21
AP8700055A0 (en) 1986-11-01
JPS63502588A (ja) 1988-09-29
WO1987004436A1 (en) 1987-07-30
JPH07107066B2 (ja) 1995-11-15
DK492587D0 (da) 1987-09-18
AU606047B2 (en) 1991-01-31
HUT47937A (en) 1989-04-28

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