ES2037035T3 - Procedimiento para la preparacion de un agente para la terapia de hemofilia a resistente al factor viii. - Google Patents

Procedimiento para la preparacion de un agente para la terapia de hemofilia a resistente al factor viii.

Info

Publication number
ES2037035T3
ES2037035T3 ES198787110539T ES87110539T ES2037035T3 ES 2037035 T3 ES2037035 T3 ES 2037035T3 ES 198787110539 T ES198787110539 T ES 198787110539T ES 87110539 T ES87110539 T ES 87110539T ES 2037035 T3 ES2037035 T3 ES 2037035T3
Authority
ES
Spain
Prior art keywords
agent
viii
procedure
preparation
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787110539T
Other languages
English (en)
Inventor
Norbert Prof.Dr. Heimburger
Karlheinz Wenz
Wilfried Wormsbacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6305910&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2037035(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2037035T3 publication Critical patent/ES2037035T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBE UN AGENTE TERAPEUTICO PARA EL TRATAMIENTO DE UNA HEMOFILIA A RESISTENTE AL FACTOR VIII, QUE SE OBTIENE MANTENIENDO UNA MEZCLA DE FACTOR VIII, ANTOTROMBINA III, UN FOSFOLIPEDO E IONES CALCIO EN UNA SOLUCION ACUOSA DURANTE 1 MINUTO POR LO MENOS, A UNA TEMPERATURA DE 1 A 45 GRADOS CENTIGRADOS, SE AÑADE FACTOR IX Y SE MANTIENE LA SOLUCION A UNA TEMPERATURA DE Y A 45 GRADOS CENTIGRADOS HASTA QUE A UNA MUESTRA DE ESTA SOLUCION SE LE AÑADE UN PLASMA CON CUERPOS INHIBIDORES Y MUESTRA UN TIEMPO DE TROMBOPLASTINA (PTZ) DE 15 A 30 SEGUNDOS, SE AÑADE EVENTUALMENTE UN POLIOL Y EVENTUALMENTE UN AMINOACIDO, Y SE SECA EVENTUALMENTE LA SOLUCION.
ES198787110539T 1986-07-24 1987-07-21 Procedimiento para la preparacion de un agente para la terapia de hemofilia a resistente al factor viii. Expired - Lifetime ES2037035T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863625090 DE3625090A1 (de) 1986-07-24 1986-07-24 Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung

Publications (1)

Publication Number Publication Date
ES2037035T3 true ES2037035T3 (es) 1993-06-16

Family

ID=6305910

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787110539T Expired - Lifetime ES2037035T3 (es) 1986-07-24 1987-07-21 Procedimiento para la preparacion de un agente para la terapia de hemofilia a resistente al factor viii.

Country Status (12)

Country Link
US (1) US5091363A (es)
EP (1) EP0255651B1 (es)
JP (1) JP2535547B2 (es)
AT (1) ATE73673T1 (es)
AU (1) AU607924B2 (es)
CA (1) CA1321139C (es)
DE (2) DE3625090A1 (es)
DK (1) DK166652B1 (es)
ES (1) ES2037035T3 (es)
FI (1) FI87044C (es)
GR (1) GR3004868T3 (es)
PT (1) PT85386B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03215430A (ja) * 1990-01-19 1991-09-20 Kita Kiyoshi 関節腔抗凝固剤
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
DE4001451A1 (de) * 1990-01-19 1991-08-01 Octapharma Ag Stabile injizierbare loesungen von faktor viii und faktor ix
AT395597B (de) * 1991-01-25 1993-01-25 Immuno Ag Reagens zur bestimmung von faktor viii-aktivitaet
CA2090738C (en) * 1993-02-24 1996-05-21 Hema-Quebec Use of paf
US7582712B1 (en) 2008-05-09 2009-09-01 Formosa Plastics Corporation, U.S.A. Alpha-olefins polymerization catalyst
CN108226540B (zh) * 2018-02-08 2020-07-03 武汉市长立生物技术有限责任公司 一种鞣花酸试剂及其配制方法与活化部分凝血活酶时间测定试剂、aptt试剂盒

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2550011C2 (de) * 1975-11-07 1982-11-25 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines antihämophilen Mittels
AT350726B (de) * 1976-08-30 1979-06-11 Immuno Ag Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
FR2472390A1 (fr) * 1979-05-04 1981-07-03 Merieux Inst Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus
JPS56127308A (en) * 1980-03-11 1981-10-06 Green Cross Corp:The Blood-coagulation factor 8 pharmaceutical
US4364861A (en) * 1980-05-27 1982-12-21 Cutter Laboratories, Inc. Blood-coagulation-promoting products and methods of preparing them
US4404132A (en) * 1980-05-27 1983-09-13 Cutter Laboratories, Inc. Blood coagulation promoting product
JPS5770814A (en) * 1980-10-17 1982-05-01 Isamu Horikoshi Oral preparation of blood clotting eighth factor
JPS5874617A (ja) * 1981-10-28 1983-05-06 Green Cross Corp:The 人由来血液凝固第７因子含有水溶液の加熱処理方法
DE3237512A1 (de) * 1982-10-09 1984-04-12 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat
US4650858A (en) * 1983-03-21 1987-03-17 Nordisk Gentofte A/S Concentrate of the antihemophilic factor VIII and a process for producing it
AT379510B (de) * 1983-05-20 1986-01-27 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation
US4610880A (en) * 1983-06-27 1986-09-09 Queen's University At Kingston Composition for controlling hemophilia in mammals
US4536392A (en) * 1983-06-27 1985-08-20 Queen's University At Kingston Method for controlling hemophilia in mammals
US4710381A (en) * 1984-05-22 1987-12-01 The Blood Center Of Southeastern Wisconsin Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing

Also Published As

Publication number Publication date
DE3777482D1 (de) 1992-04-23
GR3004868T3 (es) 1993-04-28
US5091363A (en) 1992-02-25
DK166652B1 (da) 1993-06-28
PT85386B (pt) 2001-05-31
DK384687A (da) 1988-01-25
FI873222A (fi) 1988-01-25
JP2535547B2 (ja) 1996-09-18
EP0255651A2 (de) 1988-02-10
JPS6345224A (ja) 1988-02-26
CA1321139C (en) 1993-08-10
PT85386A (pt) 1988-07-29
FI87044C (fi) 1992-11-25
DE3625090A1 (de) 1988-01-28
FI873222A0 (fi) 1987-07-22
AU7604987A (en) 1988-01-28
EP0255651A3 (en) 1989-10-11
ATE73673T1 (de) 1992-04-15
DK384687D0 (da) 1987-07-23
FI87044B (fi) 1992-08-14
AU607924B2 (en) 1991-03-21
EP0255651B1 (de) 1992-03-18

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