ES2032799T3 - Procedimiento para preparar sustitutivos de la sangre exentos de estroma. - Google Patents

Procedimiento para preparar sustitutivos de la sangre exentos de estroma.

Info

Publication number
ES2032799T3
ES2032799T3 ES198787115562T ES87115562T ES2032799T3 ES 2032799 T3 ES2032799 T3 ES 2032799T3 ES 198787115562 T ES198787115562 T ES 198787115562T ES 87115562 T ES87115562 T ES 87115562T ES 2032799 T3 ES2032799 T3 ES 2032799T3
Authority
ES
Spain
Prior art keywords
kpa
exempt
stroke
procedure
blood substitutes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787115562T
Other languages
English (en)
Inventor
Wolfgang Dr. Feller
Norbert Macht
Johannes Dr. Bottrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Melsungen AG
Original Assignee
B Braun Melsungen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B Braun Melsungen AG filed Critical B Braun Melsungen AG
Application granted granted Critical
Publication of ES2032799T3 publication Critical patent/ES2032799T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA INVENCION SE REFIERE A PRODUCTOS SUSTITUIVOS DE LA SANGRE, EXENTOS DE ESTROMA, CARACTERIZADOS PORQUE SE ENLAZAN, EN FORMA COVALENTE, CON HEMOGLOBINA, FRAGMENTOS DE GLUCOSAMINOGLUCANOS SULFATADOS, OBTENIDOS POR METODOS CONOCIDOS, DE MODO QUE SE FORMAN PRODUCTOS CUYA RELACION DE UNION CON OXIGENO SE PUEDE AJUSTAR EN EL INTERVALO DE 2,66 PKA (20 ,, DE HG) HASTA 10,66 PKA (80 MM DE HG), PREFERENTEMENTE, EN EL INTERVALO DE 4,79 PKA (36 MM DE HG) HASTA 9,33 (70 MM DE HG UTILIZANDO PARA ELLO EL AJUSTE DE LA RELACION ENTRE LA HEMOGLOBINA Y EL FRAGMENTO DE GLUCOSAMINOGLUCANO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA OBTENCION DE PRODUCTOS SUSTITUTIVOS DE LA SANGRE.
ES198787115562T 1986-10-28 1987-10-23 Procedimiento para preparar sustitutivos de la sangre exentos de estroma. Expired - Lifetime ES2032799T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863636590 DE3636590A1 (de) 1986-10-28 1986-10-28 Blutersatzmittel

Publications (1)

Publication Number Publication Date
ES2032799T3 true ES2032799T3 (es) 1993-03-01

Family

ID=6312609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787115562T Expired - Lifetime ES2032799T3 (es) 1986-10-28 1987-10-23 Procedimiento para preparar sustitutivos de la sangre exentos de estroma.

Country Status (6)

Country Link
US (1) US4920194A (es)
EP (1) EP0265865B1 (es)
JP (1) JPS63122629A (es)
AT (1) ATE76752T1 (es)
DE (2) DE3636590A1 (es)
ES (1) ES2032799T3 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600894B1 (fr) * 1986-07-02 1989-01-13 Centre Nat Rech Scient Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US5545727A (en) 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
JP2975632B2 (ja) * 1990-03-30 1999-11-10 生化学工業株式会社 グリコサミノグリカン修飾プロテイン
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
AU9067791A (en) * 1990-11-20 1992-06-11 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
DE69226197T2 (de) * 1991-11-08 1999-02-11 Somatogen Inc Hämoglobine als arzneimittelabgabesystem
DE69401109T2 (de) * 1993-03-16 1997-05-28 Hemosol Inc Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5514665A (en) * 1993-12-30 1996-05-07 University Of British Columbia Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US5895810A (en) * 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US5691453A (en) * 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6562781B1 (en) 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6491965B1 (en) 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
AU735799C (en) * 1997-02-28 2005-04-28 Regents Of The University Of California, The Methods and compositions for optimisation of oxygen transport by cell-free systems
JP5099951B2 (ja) 1999-11-12 2012-12-19 バクスター・インターナショナル・インコーポレイテッド 副作用が減少されたヘモグロビン組成物
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20070123698A1 (en) * 2003-12-26 2007-05-31 Oxygenix Co., Ltd. Process for purification of hemoglobin
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US20120238523A1 (en) * 2009-12-09 2012-09-20 Agency For Science, Technology And Research Glycosaminoglycan mixtures
LT2861626T (lt) * 2012-06-15 2019-01-25 Merz Pharma Gmbh & Co. Kgaa Paruošimo būdas kompozicijos hialurono rūgšties pagrindu

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
DE2616086C2 (de) * 1976-04-13 1986-04-03 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Substanz zur Verwendung in einem kolloidalen Blutvolumenersatzmittel aus Hydroxyethylstärke und Hämoglobin
US4401652A (en) * 1980-12-31 1983-08-30 Allied Corporation Process for the preparation of stroma-free hemoglobin solutions
US4547490A (en) * 1981-12-31 1985-10-15 Neomed, Inc. Synthetic whole blood and a method of making the same
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
DE3340592A1 (de) * 1983-11-10 1985-05-23 B. Braun Melsungen Ag, 3508 Melsungen Konjugate makromolekularer verbindungen an haemoglobine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3501349A1 (de) * 1985-01-17 1986-07-17 Battelle-Institut E.V., 6000 Frankfurt Blutersatz

Also Published As

Publication number Publication date
EP0265865A2 (de) 1988-05-04
ATE76752T1 (de) 1992-06-15
EP0265865A3 (en) 1989-01-04
JPS63122629A (ja) 1988-05-26
DE3779561D1 (de) 1992-07-09
DE3636590A1 (de) 1988-05-26
US4920194A (en) 1990-04-24
EP0265865B1 (de) 1992-06-03

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