ES2030650T1 - Dispositivo de cultivo celular. - Google Patents

Dispositivo de cultivo celular.

Info

Publication number
ES2030650T1
ES2030650T1 ES199191907500T ES91907500T ES2030650T1 ES 2030650 T1 ES2030650 T1 ES 2030650T1 ES 199191907500 T ES199191907500 T ES 199191907500T ES 91907500 T ES91907500 T ES 91907500T ES 2030650 T1 ES2030650 T1 ES 2030650T1
Authority
ES
Spain
Prior art keywords
cell culture
pct
wall
permeable
culture device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES199191907500T
Other languages
English (en)
Inventor
Patrick Binot
Dominique Cognard
Frederic Dufau
Jean Hache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bertin Technologies SAS
Original Assignee
Bertin et Cie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bertin et Cie SA filed Critical Bertin et Cie SA
Publication of ES2030650T1 publication Critical patent/ES2030650T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

DISPOSITIVO DE CULTIVO CELULAR O BIORREACTOR DE MASA EN CONTINUO QUE PERMITE EN PARTICULAR LA OBTENCION MEJORADA DE LOS PRODUCTOS DE DICHOS CULTIVOS, DEL TIPO QUE COMPRENDE UN ESPACIO DE CULTIVO CELULAR (X) EN EL QUE LAS CELULAS ESTAN CONFINADAS EN UN MEDIO LIQUIDO, ESTANDO DELIMITADO DICHO ESPACIO POR PAREDES DE LAS QUE AL MENOS TRES SON SELECTIVAMENTE PERMEABLES, LA PRIMERA EL MEDIO NUTRITIVO FRESCO, LA SEGUNDA A LOS FLUIDOS GASEOSOS Y LA ULTIMA AL MEDIO NUTRITIVO USADO Y MEDIOS DE CIRCULACION DE LOS FLUIDOS EN DICHO DISPOSITIVO, DICHO DISPOSITIVO SE CARACTERIZA EN QUE LA PRIMERA PARED ESTA CONSTITUIDA POR UNA CAPA DE TUBOS (T) DE PARED PERMEABLE AL MEDIO NUTRITIVO FRESCO, ESTANDO MONTADOS DICHOS TUBOS EN PARALELO ENTRE UN COLECTOR DE ENTRADA (42) Y UN COLECTOR DE SALIDA (43) EN UN CIRCUITO DE BUCLE CERRADO (10, 11, 16), QUE INCLUYE MEDIOS DE SUMINISTRO (10; 40) DE DICHO MEDIO NUTRITIVO FRESCO Y QUE SON RECORRIDOS CADA UNO DE EXTREMO A EXTREMO POR UN FLUJO DE MEDIO FRESCO VARIAS VECES SUPERIOR AL QUE ATRAVIESA SU PARED.
ES199191907500T 1990-03-30 1991-03-28 Dispositivo de cultivo celular. Pending ES2030650T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9004092A FR2660323B1 (fr) 1990-03-30 1990-03-30 Dispositif de culture cellulaire.

Publications (1)

Publication Number Publication Date
ES2030650T1 true ES2030650T1 (es) 1992-11-16

Family

ID=9395286

Family Applications (1)

Application Number Title Priority Date Filing Date
ES199191907500T Pending ES2030650T1 (es) 1990-03-30 1991-03-28 Dispositivo de cultivo celular.

Country Status (11)

Country Link
US (1) US5290700A (es)
EP (1) EP0474847B1 (es)
JP (1) JP3078317B2 (es)
KR (1) KR920701417A (es)
AT (1) ATE127837T1 (es)
CA (1) CA2054761C (es)
DE (1) DE69112965T2 (es)
ES (1) ES2030650T1 (es)
FR (1) FR2660323B1 (es)
GR (1) GR920300050T1 (es)
WO (1) WO1991015570A1 (es)

Families Citing this family (44)

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DE4230194C2 (de) * 1992-09-09 1995-07-27 Joerg Dr Med Gerlach Reaktor zur Züchtung und zur Nutzung von Stoffwechselleistungen und/oder zum Erhalt von Mikroorganismen
FR2706483B1 (fr) * 1993-06-09 1995-09-01 Bertin & Cie Bioréacteur, destiné notamment à la culture de cellules.
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
US5622857A (en) * 1995-08-08 1997-04-22 Genespan Corporation High performance cell culture bioreactor and method
GB9503197D0 (en) * 1995-02-18 1995-04-05 Atomic Energy Authority Uk A bioreactor
BE1009306A5 (fr) 1995-04-28 1997-02-04 Baxter Int Bioreacteur.
GB9602444D0 (en) 1996-02-07 1996-04-03 Chege Joseph Pharmaceutical compositions for the prevention or treatment of retrovirus infections
FR2762092B1 (fr) 1997-04-15 1999-05-28 Bio Merieux Procede et dispositif de remplissage avec un milieu liquide d'une carte d'analyse
FR2771421B1 (fr) * 1997-11-27 2001-05-04 Bertin & Cie Dispositif d'amplification de cellules hematopoietiques et ses applications
US20020034819A1 (en) * 1998-02-23 2002-03-21 Alan K. Smith Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses
DE19810901C1 (de) * 1998-03-13 1999-06-17 Ascalon Gesellscchaft Fuer Inn Bioreaktor
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
WO2000053796A1 (de) * 1999-03-09 2000-09-14 Acordis Industrial Fibers Gmbh Membranmodul zum testen von wirkstoffen an zellen
FR2794130B1 (fr) * 1999-05-26 2003-01-03 Bertin Technologies Sa Procede et dispositif de culture de cellules a applications multiples
EP1185612B1 (en) * 1999-06-03 2004-08-25 The University of North Carolina at Chapel Hill Bioreactor design and process for engineering tissue from cells
JP2002112763A (ja) * 2000-10-10 2002-04-16 Nipro Corp 細胞培養容器
US6582955B2 (en) * 2001-05-11 2003-06-24 Spectrum Laboratories, Inc. Bioreactor with application as blood therapy device
US6566126B2 (en) * 2001-06-22 2003-05-20 Fibercell Systems, Inc. Apparatus and method for growing cells
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
EP1479760A1 (de) * 2003-05-19 2004-11-24 ProBioGen AG Künstliches Immunorgan
DE10326748B4 (de) * 2003-06-13 2006-11-23 Gerlach, Jörg, Dr.med. Nervenzellkulturbioreaktor und hybrides Nervenzellsystem
DE10326747B4 (de) * 2003-06-13 2006-11-02 Gerlach, Jörg, Dr.med. Perfusionseinheit und Perfusionsstation zur Hautwundbehandlung sowie dessen Verwendung
US20050026275A1 (en) * 2003-06-23 2005-02-03 Andrej Bahoric Device, system and method for receiving, processing and dispersing cells
WO2005008419A2 (en) * 2003-07-10 2005-01-27 Comcast Cable Holdings, Llc Distributed and scalable architecture for on demand session and resource management
US7514256B2 (en) * 2005-02-11 2009-04-07 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
GB0505377D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Capilliary devices for cell and embryo culture
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US9260688B2 (en) 2005-07-07 2016-02-16 The Regents Of The University Of California Methods and apparatus for cell culture array
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9376658B2 (en) 2008-01-03 2016-06-28 Emd Millipore Corporation Cell culture array system for automated assays and methods of operation and manufacture thereof
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
US9309491B2 (en) 2007-05-29 2016-04-12 Corning Incorporated Cell culture apparatus for co-culture of cells
EP2130905A1 (en) * 2008-06-04 2009-12-09 Pharmacell B.V. Method for culturing eukaryotic cells
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
WO2012024646A2 (en) * 2010-08-19 2012-02-23 The Johns Hopkins University Cell culture system and method of use thereof
EP2444478A1 (en) 2010-10-22 2012-04-25 Gerlach, Jörg, Dr. med. Tubular body fluid mass exchange system and mass exchange device
DE102010064098B4 (de) * 2010-12-23 2014-02-13 Hochschule Wismar Zellreaktor
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
DE102011106914B4 (de) 2011-07-08 2015-08-27 Zellwerk Gmbh Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen
SG10201604400RA (en) 2011-12-03 2016-07-28 Emd Millipore Corp Micro-incubation systems for microfluidic cell culture and methods
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US4087327A (en) * 1976-04-12 1978-05-02 Monsanto Company Mammalion cell culture process
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
US4442206A (en) * 1980-08-21 1984-04-10 Stanford University Method of using isotropic, porous-wall polymeric membrane, hollow-fibers for culture of microbes
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
FR2580514B1 (fr) * 1985-04-17 1989-08-18 Lyonnaise Eaux Ensemble composite de membranes de filtration et son utilisation dans un bioreacteur
US4610789A (en) * 1985-04-22 1986-09-09 Ppg Industries, Inc. Filtration cartridge and reactor
JPH04506149A (ja) * 1989-05-05 1992-10-29 セントコール，インコーポレイテッド 改良された細胞培養系

Also Published As

Publication number Publication date
CA2054761A1 (en) 1991-10-01
US5290700A (en) 1994-03-01
JP3078317B2 (ja) 2000-08-21
KR920701417A (ko) 1992-08-11
GR920300050T1 (en) 1992-08-31
FR2660323A1 (fr) 1991-10-04
EP0474847B1 (fr) 1995-09-13
CA2054761C (en) 2002-01-08
EP0474847A1 (fr) 1992-03-18
WO1991015570A1 (fr) 1991-10-17
ATE127837T1 (de) 1995-09-15
DE69112965D1 (de) 1995-10-19
JPH05500616A (ja) 1993-02-12
DE69112965T2 (de) 1996-04-04
FR2660323B1 (fr) 1992-07-24

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