ES2028008T3 - Procedimiento para preparar derivados de benzotiazepina. - Google Patents

Procedimiento para preparar derivados de benzotiazepina.

Info

Publication number
ES2028008T3
ES2028008T3 ES198787112096T ES87112096T ES2028008T3 ES 2028008 T3 ES2028008 T3 ES 2028008T3 ES 198787112096 T ES198787112096 T ES 198787112096T ES 87112096 T ES87112096 T ES 87112096T ES 2028008 T3 ES2028008 T3 ES 2028008T3
Authority
ES
Spain
Prior art keywords
alkyl
benzotiazepine
derivatives
preparing
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787112096T
Other languages
English (en)
Inventor
David Mack Floyd
Karnail Singh Atwal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of ES2028008T3 publication Critical patent/ES2028008T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I) O A SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN LOS QUE LA ESTEREOQUIMICA DE LOS CENTROS QUIRALES DE LAS POSICIONES 3 Y 4 DEL NUCLEO DE BENZOTIAZEPINA ES CIS, Y EN LOS QUE R1 ES ALQUILO, ARILO, ARILALQUILO, ALQUENILO O ALQUINILO; R2 Y R5 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO O ALCOXI DE 1 A 4 ATOMOS DE C, HALOGENO O TRIFLUORMETILO; Y R3 Y R4 SON CADA UNO INDEPENDIENTEMENTE ALQUILO O CICLOALQUILO, O JUNTOS CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS SON PIRROLIDINILO, PIPERIDINILO O MORFOLINILO. ESTOS COMPUESTOS POSEEN ACTIVIDAD BLOQUEANTE DE LOS CANALES DE CALCIO.
ES198787112096T 1986-08-21 1987-08-20 Procedimiento para preparar derivados de benzotiazepina. Expired - Lifetime ES2028008T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/898,570 US4694002A (en) 1986-08-21 1986-08-21 Benzothiazepine derivatives

Publications (1)

Publication Number Publication Date
ES2028008T3 true ES2028008T3 (es) 1992-07-01

Family

ID=25409650

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787112096T Expired - Lifetime ES2028008T3 (es) 1986-08-21 1987-08-20 Procedimiento para preparar derivados de benzotiazepina.

Country Status (8)

Country Link
US (1) US4694002A (es)
EP (1) EP0262373B1 (es)
JP (1) JPS6351381A (es)
AT (1) ATE72242T1 (es)
CA (1) CA1338417C (es)
DE (1) DE3776478D1 (es)
ES (1) ES2028008T3 (es)
GR (1) GR3004426T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607004B1 (fr) * 1986-11-20 1990-06-01 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
US4871731A (en) * 1987-10-07 1989-10-03 Marion Laboratories, Inc. Captopril and diltiazem composition and the like
US5008411A (en) * 1988-05-24 1991-04-16 Hoffmann-La Roche Inc. Glycidic acid ester and process of preparation
US5037821A (en) * 1988-06-01 1991-08-06 E. R. Squibb & Sons, Inc. Method for inhibiting loss of cognitive functions employing a calcium channel blocker alone or in combination with an ACE inhibitor
DE3990664T1 (de) * 1988-06-20 1991-04-25 Squibb & Sons Inc Benzazepin- und benzothiazepin-derivate
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
WO1990006118A1 (en) * 1988-12-05 1990-06-14 Houston Biotechnology Incorporated Therapeutic use of dihydropyrimidones and benzazepine and benzothiazepine derivatives in retinal or optic nerve dysfunction
US4952692A (en) * 1989-04-04 1990-08-28 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
FR2645744B1 (fr) * 1989-04-13 1994-01-21 Roussel Uclaf Derives de la benzothiazepine, leur procede de preparation et les intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
US5559017A (en) * 1989-08-09 1996-09-24 E. R. Squibb & Sons, Inc. Microbial reduction of benzazepines and benzothiazepine derivatives
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines
WO2010022259A1 (en) * 2008-08-22 2010-02-25 Milestone Pharmaceuticals Inc. Short acting benzothiazepine calcium channel blockers and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
GB2017080B (en) * 1978-02-14 1982-07-21 Maruko Pharmaceutical Co Benzothiazepines
US4552695A (en) * 1983-04-21 1985-11-12 Shionogi & Co., Ltd. Process for production of diltiazem hydrochloride
US4590188A (en) * 1984-02-18 1986-05-20 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and their pharmaceutical use

Also Published As

Publication number Publication date
GR3004426T3 (es) 1993-03-31
DE3776478D1 (de) 1992-03-12
ATE72242T1 (de) 1992-02-15
US4694002A (en) 1987-09-15
CA1338417C (en) 1996-06-25
JPS6351381A (ja) 1988-03-04
EP0262373A1 (en) 1988-04-06
EP0262373B1 (en) 1992-01-29

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