ES2027985T3 - Metodo y aparato de determinar el recuento por volumen unitario de particulas. - Google Patents

Metodo y aparato de determinar el recuento por volumen unitario de particulas.

Info

Publication number
ES2027985T3
ES2027985T3 ES198787104908T ES87104908T ES2027985T3 ES 2027985 T3 ES2027985 T3 ES 2027985T3 ES 198787104908 T ES198787104908 T ES 198787104908T ES 87104908 T ES87104908 T ES 87104908T ES 2027985 T3 ES2027985 T3 ES 2027985T3
Authority
ES
Spain
Prior art keywords
particles
volume
count
determining
unit volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787104908T
Other languages
English (en)
Inventor
Warren Groner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of ES2027985T3 publication Critical patent/ES2027985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ship Loading And Unloading (AREA)

Abstract

UN METODO Y APARATO PARA DETERMINAR CON EXACTITUD LA CANTIDAD DE PARTICULAS POR UNIDAD DE VOLUMEN. TALES COMO CELULAS ROJAS DE SANGRE, SUSPENDIDAS EN UN FLUIDO QUE CONTIENE POR LO MENOS UNA PARTICULA DE INTERFERENCIA INDESEABLE TAL COMO BURBUJAS DE AIRE. UN VOLUMEN PREDETERMINADO DE FLUIDO, QUE CONTIENE LA PRIMERA Y SEGUNDA PARTICULAS, SE PASA A TRAVES DE UN CITOMETRO DE FLUJO, QUE PRODUCE UN PATRON DE ONDA DE DISPERSION DE LA LUZ, QUE ES DETECTADA Y MEDIDA. SE DETERMINA EL VOLUMEN Y EL INDICE DE REFRACCION DE CADA UNA DE LAS PRIMERA Y SEGUNDA PARTICULAS. ESTAS SE DISTINGUEN EN BASE A SUS INDICES DE REFRACCION RESPECTIVOS, Y SE CORRIGE LA CANTIDAD TOTAL Y EL VOLUMEN DE PARTICULAS PARA OBTENER LA CANTIDAD DE CELULAS ROJAS DE SANGRE POR UNIDAD DE VOLUMEN.
ES198787104908T 1986-04-04 1987-04-02 Metodo y aparato de determinar el recuento por volumen unitario de particulas. Expired - Lifetime ES2027985T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/848,172 US4989978A (en) 1986-04-04 1986-04-04 Method and apparatus for determining the count per unit volume of particles

Publications (1)

Publication Number Publication Date
ES2027985T3 true ES2027985T3 (es) 1992-07-01

Family

ID=25302552

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787104908T Expired - Lifetime ES2027985T3 (es) 1986-04-04 1987-04-02 Metodo y aparato de determinar el recuento por volumen unitario de particulas.

Country Status (7)

Country Link
US (1) US4989978A (es)
EP (1) EP0240942B1 (es)
JP (1) JPS62239289A (es)
AU (1) AU590683B2 (es)
CA (1) CA1272805C (es)
DE (1) DE3775961D1 (es)
ES (1) ES2027985T3 (es)

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US5488469A (en) * 1991-08-30 1996-01-30 Omron Corporation Cell analyzing apparatus
DE69230902D1 (de) * 1991-08-30 2000-05-18 Omron Tateisi Electronics Co Vorrichtung zur Zellenanalyse
US5451525A (en) * 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
DE69327182T2 (de) * 1992-02-18 2000-06-15 Hitachi, Ltd. Gerät und Verfahren zur Untersuchung von Teilchen in einem Fluid
WO1994027146A1 (en) * 1993-05-14 1994-11-24 Coulter Corporation Reticulocyte analyzing method and apparatus utilizing light scatter techniques
US6790366B2 (en) * 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
US6660159B1 (en) 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US6890426B2 (en) * 1996-06-07 2005-05-10 Immunivest Corporation Magnetic separation apparatus and methods
US6136182A (en) * 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US7666308B2 (en) * 1996-06-07 2010-02-23 Veridex, Llc. Magnetic separation apparatus and methods
AU3374597A (en) * 1996-06-07 1998-01-05 Immunivest Corporation Magnetic separation employing external and internal gradients
US6172376B1 (en) 1997-12-17 2001-01-09 American Air Liquide Inc. Method and system for measuring particles in a liquid sample
US6813017B1 (en) 1999-10-20 2004-11-02 Becton, Dickinson And Company Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
EP1222451A1 (en) * 1999-10-20 2002-07-17 Becton, Dickinson and Company An apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
WO2002025247A2 (en) 2000-09-20 2002-03-28 Menguc M Pinar A non-intrusive method and apparatus for characterizing particles based on scattering of elliptically polarized radiation
JP3720799B2 (ja) * 2002-10-02 2005-11-30 神栄株式会社 花粉センサ
US7092078B2 (en) 2003-03-31 2006-08-15 Nihon Kohden Corporation Flow cytometer for classifying leukocytes and method for determining detection angle range of the same
US7356365B2 (en) * 2003-07-09 2008-04-08 Glucolight Corporation Method and apparatus for tissue oximetry
SE0302676D0 (sv) * 2003-10-09 2003-10-09 Neural Ab Method and apparatus for holographic refractometry
US7510849B2 (en) * 2004-01-29 2009-03-31 Glucolight Corporation OCT based method for diagnosis and therapy
CN1985168B (zh) * 2004-05-14 2013-01-02 霍尼韦尔国际公司 具有可拆卸盒的便携式样本分析仪
US8036727B2 (en) 2004-08-11 2011-10-11 Glt Acquisition Corp. Methods for noninvasively measuring analyte levels in a subject
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
JP2008537903A (ja) 2005-04-13 2008-10-02 グルコライト・コーポレーシヨン Ｏｃｔが基になった血糖モニターのデータ処理および較正方法
US8768423B2 (en) 2008-03-04 2014-07-01 Glt Acquisition Corp. Multispot monitoring for use in optical coherence tomography
EP4180794A3 (en) 2011-12-01 2023-08-09 Particle Measuring Systems Inc. Detection scheme for particle size and concentration measurement
JP2015031665A (ja) * 2013-08-06 2015-02-16 トライボテックス株式会社 粒子計数装置及び粒子計数方法
CN107870139B (zh) * 2016-09-27 2023-10-27 深圳长城开发科技股份有限公司 一种无损检测产品表面颗粒污染物的装置及方法
WO2019082186A1 (en) 2017-10-26 2019-05-02 Particle Measuring Systems, Inc. SYSTEM AND METHOD FOR MEASURING PARTICLES
WO2020146967A1 (zh) * 2019-01-14 2020-07-23 深圳迈瑞生物医疗电子股份有限公司 一种样本光学检测装置
EP3959505B1 (en) 2019-04-25 2024-05-08 Particle Measuring Systems, Inc. Particle detection systems and methods for on-axis particle detection and/or differential detection
CN114729868A (zh) 2019-11-22 2022-07-08 粒子监测系统有限公司 先进的用于干涉测量颗粒检测和具有小大小尺寸的颗粒的检测的系统和方法
CN119880716B (zh) * 2025-03-27 2025-06-24 烟台格藻生物科技有限公司 应用于生物信息的细胞数量测量方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3520316A (en) * 1963-12-12 1970-07-14 Bowles Eng Corp Pressure-to-pressure transducer
US3740143A (en) * 1970-10-30 1973-06-19 Technicon Instr Automatic apparatus for determining the percentage population of particulates in a medium
US4202625A (en) * 1978-08-18 1980-05-13 Ortho Diagnostics, Inc. Method and apparatus for discriminating red blood cells from platelets
US4577964A (en) * 1978-09-06 1986-03-25 Ortho Diagnostics, Inc. Apparatus and method for detecting platelets in whole blood
US4429995A (en) * 1980-07-21 1984-02-07 National Research Development Corporation Two dimensinal flow analyzer
US4548500A (en) * 1982-06-22 1985-10-22 Wyatt Philip J Process and apparatus for identifying or characterizing small particles
JPS5994037A (ja) * 1982-11-19 1984-05-30 Shimadzu Corp 血球計数装置
US4735504A (en) * 1983-10-31 1988-04-05 Technicon Instruments Corporation Method and apparatus for determining the volume & index of refraction of particles

Also Published As

Publication number Publication date
EP0240942A2 (en) 1987-10-14
EP0240942A3 (en) 1988-04-06
EP0240942B1 (en) 1992-01-15
CA1272805A (en) 1990-08-14
AU590683B2 (en) 1989-11-09
JPH0543154B2 (es) 1993-06-30
JPS62239289A (ja) 1987-10-20
US4989978A (en) 1991-02-05
AU6958587A (en) 1987-10-08
CA1272805C (en) 1990-08-14
DE3775961D1 (de) 1992-02-27

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