ES2016957B3 - Procedimiento para la obtencion de n,n'-diarilreas. - Google Patents

Procedimiento para la obtencion de n,n'-diarilreas.

Info

Publication number
ES2016957B3
ES2016957B3 ES87114817T ES87114817T ES2016957B3 ES 2016957 B3 ES2016957 B3 ES 2016957B3 ES 87114817 T ES87114817 T ES 87114817T ES 87114817 T ES87114817 T ES 87114817T ES 2016957 B3 ES2016957 B3 ES 2016957B3
Authority
ES
Spain
Prior art keywords
diarilreas
procedure
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87114817T
Other languages
English (en)
Spanish (es)
Inventor
Wolfram Kissener
Joachim Franke
Helmut Fiege
Karlfried Wedemeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2016957B3 publication Critical patent/ES2016957B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES87114817T 1986-10-24 1987-10-10 Procedimiento para la obtencion de n,n'-diarilreas. Expired - Lifetime ES2016957B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863636190 DE3636190A1 (de) 1986-10-24 1986-10-24 Verfahren zur herstellung von n,n-diaryl-harnstoffen

Publications (1)

Publication Number Publication Date
ES2016957B3 true ES2016957B3 (es) 1990-12-16

Family

ID=6312378

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87114817T Expired - Lifetime ES2016957B3 (es) 1986-10-24 1987-10-10 Procedimiento para la obtencion de n,n'-diarilreas.

Country Status (7)

Country Link
US (1) US4820871A (member.php)
EP (1) EP0264752B1 (member.php)
JP (1) JPS63122660A (member.php)
CA (1) CA1295340C (member.php)
DE (2) DE3636190A1 (member.php)
DK (1) DK555687A (member.php)
ES (1) ES2016957B3 (member.php)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0410168B1 (de) * 1989-07-28 1994-12-14 Chemie Linz GmbH Verfahren zur Herstellung unsymmetrisch substituierter Harnstoffe
US5248755A (en) * 1989-07-28 1993-09-28 Chemie Linz Gesellschaft M.B.H. Process for the preparation of asymmetrically substituted ureas, carbamates or thiocarbamates
US5220061A (en) * 1992-02-07 1993-06-15 Arco Chemical Technology, L.P. Selective process for the preparation of diphenylmethane bis-(dialkyl ureas
JP3372436B2 (ja) * 1996-11-28 2003-02-04 オークマ株式会社 インバータの制御装置
US6344476B1 (en) * 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
WO2000042012A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
IL144144A0 (en) * 1999-01-13 2002-05-23 Bayer Ag Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
AU7353300A (en) * 1999-09-08 2001-04-10 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
JP2004532187A (ja) 2001-01-25 2004-10-21 ギルフォード ファーマシュウティカルズ インコーポレイテッド 三置換カルボサイクリックサイクロフィリン結合化合物とその用途
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ES2393900T3 (es) * 2001-12-03 2012-12-28 Bayer Healthcare Llc Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
SI1478358T1 (sl) * 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
AU2003210969A1 (en) * 2002-02-11 2003-09-04 Bayer Corporation Aryl ureas with raf kinase and angiogenesis inhibiting activity
PT1580188E (pt) * 2002-02-11 2012-01-25 Bayer Healthcare Llc Aril-ureias como inibidores de cinases
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
JP4860474B2 (ja) * 2003-05-20 2012-01-25 バイエル、ファーマシューテイカルズ、コーポレイション Ｐｄｇｆｒによって仲介される病気のためのジアリール尿素
CL2004001834A1 (es) * 2003-07-23 2005-06-03 Bayer Pharmaceuticals Corp Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol
CN101010315A (zh) * 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
CN102924336A (zh) * 2012-09-28 2013-02-13 黎明化工研究设计院有限责任公司 一种制备n-甲基-n’，n’-二苯基脲的方法
CN103232371B (zh) * 2013-04-26 2014-11-26 黎明化工研究设计院有限责任公司 一种制备n-甲基-n’，n’-二苯基脲的方法
EP3652230A1 (de) * 2017-07-11 2020-05-20 Covestro Deutschland AG Weichschaumstoff mit halogenfreiem flammschutz
HUE061044T2 (hu) * 2018-12-07 2023-06-28 Dow Global Technologies Llc Eljárás monoizocianátok karbamidokká konvertálására

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683727A (en) * 1954-07-13 Secondary aromatic amines
CH513134A (de) * 1968-06-10 1971-09-30 Bayer Ag Verfahren zur Herstellung von N-Arylharnstoffen
JPS5419937A (en) * 1977-07-12 1979-02-15 Showa Denko Kk Preparation of urea substitution product
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
US4410697A (en) * 1980-01-25 1983-10-18 Reanal Finomvegyszergyar Process for the preparation of N-aryl-N'-(mono- or di substituted)-urea derivatives
IT1137177B (it) * 1981-06-02 1986-09-03 Anic Spa Processo per la preparazione di uree asimmetriche a partire da uretani ed ammine
US4473579A (en) * 1982-01-26 1984-09-25 American Cyanamid Company Antiatherosclerotic tetrasubstituted ureas and thioureas

Also Published As

Publication number Publication date
CA1295340C (en) 1992-02-04
DE3764602D1 (de) 1990-10-04
EP0264752A1 (de) 1988-04-27
DK555687D0 (da) 1987-10-23
DK555687A (da) 1988-04-25
US4820871A (en) 1989-04-11
DE3636190A1 (de) 1988-04-28
EP0264752B1 (de) 1990-08-29
JPS63122660A (ja) 1988-05-26
JPH0360817B2 (member.php) 1991-09-17

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