ES2015053B3 - Antagonistas selectivos de receptores alfaadrenergicos. - Google Patents

Antagonistas selectivos de receptores alfaadrenergicos.

Info

Publication number
ES2015053B3
ES2015053B3 ES87302214T ES87302214T ES2015053B3 ES 2015053 B3 ES2015053 B3 ES 2015053B3 ES 87302214 T ES87302214 T ES 87302214T ES 87302214 T ES87302214 T ES 87302214T ES 2015053 B3 ES2015053 B3 ES 2015053B3
Authority
ES
Spain
Prior art keywords
alfaadrenergic
receptors
selective antagonists
antagonists
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87302214T
Other languages
English (en)
Inventor
Robert Michael Demarinis
Francis Richard Pfeiffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2015053B3 publication Critical patent/ES2015053B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES87302214T 1986-03-17 1987-03-16 Antagonistas selectivos de receptores alfaadrenergicos. Expired - Lifetime ES2015053B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/840,621 US4683229A (en) 1986-03-17 1986-03-17 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists

Publications (1)

Publication Number Publication Date
ES2015053B3 true ES2015053B3 (es) 1990-08-01

Family

ID=25282824

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87302214T Expired - Lifetime ES2015053B3 (es) 1986-03-17 1987-03-16 Antagonistas selectivos de receptores alfaadrenergicos.

Country Status (11)

Country Link
US (1) US4683229A (es)
EP (1) EP0238281B1 (es)
JP (1) JPS62226963A (es)
AT (1) ATE52777T1 (es)
AU (1) AU7004687A (es)
DE (1) DE3762743D1 (es)
DK (1) DK136987A (es)
ES (1) ES2015053B3 (es)
GR (1) GR3000490T3 (es)
PT (1) PT84486B (es)
ZA (1) ZA871893B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
US5281591A (en) * 1989-05-22 1994-01-25 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5180721A (en) * 1989-05-22 1993-01-19 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5021410A (en) * 1989-05-22 1991-06-04 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5252595A (en) * 1990-02-28 1993-10-12 Allergan, Inc. Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
US5639748A (en) * 1991-08-05 1997-06-17 Smithkline Beecham Corporation 6,9-disubstituted benzazepines having α-adrenoceptor blocking activity
GB9116824D0 (en) * 1991-08-05 1991-09-18 Smithkline Beecham Corp Chemical compounds
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
US5580892A (en) * 1993-10-22 1996-12-03 Allergan Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
EP0775134A4 (en) 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
US6369114B1 (en) * 1999-11-30 2002-04-09 Institute Of Critical Care Medicine Administration of an α2-adrenergic receptor agonist to enhance cardiopulmonary resuscitation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE728092A (es) * 1968-02-09 1969-07-16
US3752892A (en) * 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US4197297A (en) * 1976-11-17 1980-04-08 Smithkline Corporation 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
ZA792785B (en) * 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
EP0108170A1 (en) * 1982-10-08 1984-05-16 Smithkline Beckman Corporation 3-Benzazepines as alpha-2 antagonists
EP0161350A1 (en) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Process for preparing benzazepines
US4465677A (en) * 1982-07-14 1984-08-14 Smithkline Beckman Corporation Pharmaceutical compositions and method of producing alpha2 antagonism
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines

Also Published As

Publication number Publication date
JPS62226963A (ja) 1987-10-05
EP0238281B1 (en) 1990-05-16
EP0238281A1 (en) 1987-09-23
PT84486B (pt) 1989-11-10
DE3762743D1 (de) 1990-06-21
US4683229A (en) 1987-07-28
ATE52777T1 (de) 1990-06-15
DK136987A (da) 1987-09-18
AU7004687A (en) 1987-09-24
ZA871893B (en) 1987-11-25
DK136987D0 (da) 1987-03-17
PT84486A (en) 1987-04-01
GR3000490T3 (en) 1991-06-28

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