JPS5461181A - Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation - Google Patents

Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation

Info

Publication number
JPS5461181A
JPS5461181A JP12630077A JP12630077A JPS5461181A JP S5461181 A JPS5461181 A JP S5461181A JP 12630077 A JP12630077 A JP 12630077A JP 12630077 A JP12630077 A JP 12630077A JP S5461181 A JPS5461181 A JP S5461181A
Authority
JP
Japan
Prior art keywords
formula
methano
hexahydro
cis
benzazocine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12630077A
Other languages
Japanese (ja)
Inventor
Mikio Hori
Hajime Fujimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Original Assignee
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Production Development, Zaidan Hojin Seisan Kaihatsu Kenkyusho filed Critical Research Institute for Production Development
Priority to JP12630077A priority Critical patent/JPS5461181A/en
Publication of JPS5461181A publication Critical patent/JPS5461181A/en
Pending legal-status Critical Current

Links

Landscapes

  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:cis-8-Acylthio-3-substituted-6, 11-dimethyl-2,6-methano-1,2,3,4,5, 6- hexahydro-3-benzazocine or its acid salts of formula I: (R1 is lower alkyl, phenyl group, etc.; R is methyl or methyl-2-butenyl group).
EXAMPLE: cis-8-(Dimethylthiocarbamoyloxy)-3,6,11-trimethyl-2,6-methano-1,2,3,4, 5, 6-hexahydro-3-benzazocines.
USE: Analgesics having different points with opiate receptor in the brain different from well-known marphine and pentazocine.
PROCESS: Novel compounds of formula II are reacted with lithium aluminum hydride, and with acid halides of formula R'COX ( X is halogen) or acid anhydrides of formula (R'CO)2O to give compounds of formula I
COPYRIGHT: (C)1979,JPO&Japio
JP12630077A 1977-10-19 1977-10-19 Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation Pending JPS5461181A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12630077A JPS5461181A (en) 1977-10-19 1977-10-19 Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12630077A JPS5461181A (en) 1977-10-19 1977-10-19 Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation

Publications (1)

Publication Number Publication Date
JPS5461181A true JPS5461181A (en) 1979-05-17

Family

ID=14931783

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12630077A Pending JPS5461181A (en) 1977-10-19 1977-10-19 Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation

Country Status (1)

Country Link
JP (1) JPS5461181A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0415634A2 (en) * 1989-08-30 1991-03-06 Pfizer Inc. Benzazabicyclic carbamates as cholinesterase inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4839480A (en) * 1971-09-30 1973-06-09
JPS50130769A (en) * 1974-04-03 1975-10-16
JPS5283667A (en) * 1976-01-01 1977-07-12 Boehringer Sohn Ingelheim Novel 5*9bb2 substituted 22tetrahydrofurfuryll 6*77benzomorphane and medical compositions containing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4839480A (en) * 1971-09-30 1973-06-09
JPS50130769A (en) * 1974-04-03 1975-10-16
JPS5283667A (en) * 1976-01-01 1977-07-12 Boehringer Sohn Ingelheim Novel 5*9bb2 substituted 22tetrahydrofurfuryll 6*77benzomorphane and medical compositions containing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0415634A2 (en) * 1989-08-30 1991-03-06 Pfizer Inc. Benzazabicyclic carbamates as cholinesterase inhibitors

Similar Documents

Publication Publication Date Title
JPS5432460A (en) Cycloalkylidenemethylphenylacetic acid derivative and their preparation
DK136987A (en) SELECTIVE ALFA-ADDRENGE RECEPTOR ANTAGONISTS, PROCEDURES FOR PREPARING IT, AND PHARMACEUTICAL AGENTS CONTAINING THESE
JPS5461181A (en) Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation
IT1176779B (en) PREPARATION OF 1,1,1,3,3,3-HEXAFLUOROPROPANE-2-OL FOR HYDROGENOLYSIS OF HEXAFLUOROACETONE HYDRATE
JPS57116074A (en) Novel camptothecin derivative and its preparation
IT1157719B (en) PROCEDURE FOR THE INSULATION OF ASPARTIC ACID SALTS
JPS53116353A (en) Preparation of methylbiphenyl by methyl exchange
BE859438A (en) PROCESS FOR PREPARING A ZINC BACITRACIN COMPOSITION USED AS A FOOD SUPPLEMENT
JPS543064A (en) Benzothiazolylthiocarboxylic acid derivatives
JPS5430138A (en) Cyclopropane carboxylate and its preparation
PT67391A (en) METHOD FOR PREPARING AN INSECTICIDAL AND ANTI-PARASITE FORMULATION CONTAINING DIMETHYLFORMAMIDE AS SYNERGISING AND ENHANCING NATURAL PYRETHRINS-PYRETHRINOIDS AND ROTENONES AND SYNTHESIS
JPS5350184A (en) Novel imides and their preparation
JPS5473714A (en) 5-alkyl-1,5,5-trialkoxy-1-pentene-3-yne and its preparation
JPS5430172A (en) Pyrazolidine derivative
JPS5368777A (en) Preparation of phenyathridine
JPS5772997A (en) Novel oligomannoside and its preparation
JPS5371059A (en) Preparation of 1-substd.-3-amino-4-substd. thioazetidinone deriv. or theiracid salts
JPS5625164A (en) Tetrahydroisoquinoline compound and its preparation
JPS5427581A (en) P1-s-phenylthiop2-nucleoside 5'-pyrophosphates and their preparation
JPS5513253A (en) Cis-3-aralkyl substituted-8-benzoylthio-6,11-dimethyl-2,6- methano-1,2,3,4,5,6-hexahydro-3-benzazocine or its acid addition salt
ES468798A1 (en) Analgesic and morphine antagonistic 2{40 -hydroxy-2-(5-isoxazolyl-methyl)-6,7-benzomorphans and salts thereof
JPS5412355A (en) Alkyl cyclohexyldichlorosilane compounds and their preparation
JPS51148792A (en) Preparation of polyester
JPS57200378A (en) Halogenated pgi2 and its preparation
JPS5572168A (en) Novel isoquinoline derivative and its preparation