JPS5461181A - Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation - Google Patents
Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparationInfo
- Publication number
- JPS5461181A JPS5461181A JP12630077A JP12630077A JPS5461181A JP S5461181 A JPS5461181 A JP S5461181A JP 12630077 A JP12630077 A JP 12630077A JP 12630077 A JP12630077 A JP 12630077A JP S5461181 A JPS5461181 A JP S5461181A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- methano
- hexahydro
- cis
- benzazocine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:cis-8-Acylthio-3-substituted-6, 11-dimethyl-2,6-methano-1,2,3,4,5, 6- hexahydro-3-benzazocine or its acid salts of formula I: (R1 is lower alkyl, phenyl group, etc.; R is methyl or methyl-2-butenyl group).
EXAMPLE: cis-8-(Dimethylthiocarbamoyloxy)-3,6,11-trimethyl-2,6-methano-1,2,3,4, 5, 6-hexahydro-3-benzazocines.
USE: Analgesics having different points with opiate receptor in the brain different from well-known marphine and pentazocine.
PROCESS: Novel compounds of formula II are reacted with lithium aluminum hydride, and with acid halides of formula R'COX ( X is halogen) or acid anhydrides of formula (R'CO)2O to give compounds of formula I
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12630077A JPS5461181A (en) | 1977-10-19 | 1977-10-19 | Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12630077A JPS5461181A (en) | 1977-10-19 | 1977-10-19 | Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5461181A true JPS5461181A (en) | 1979-05-17 |
Family
ID=14931783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12630077A Pending JPS5461181A (en) | 1977-10-19 | 1977-10-19 | Cis-8-acylthio-3-substituted-6,11-dimethyl-2,6-methano-1,2,3,4,5, 6-hexahydro-3-benzazocine or its acid salts and their preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5461181A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0415634A2 (en) * | 1989-08-30 | 1991-03-06 | Pfizer Inc. | Benzazabicyclic carbamates as cholinesterase inhibitors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4839480A (en) * | 1971-09-30 | 1973-06-09 | ||
JPS50130769A (en) * | 1974-04-03 | 1975-10-16 | ||
JPS5283667A (en) * | 1976-01-01 | 1977-07-12 | Boehringer Sohn Ingelheim | Novel 5*9bb2 substituted 22tetrahydrofurfuryll 6*77benzomorphane and medical compositions containing same |
-
1977
- 1977-10-19 JP JP12630077A patent/JPS5461181A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4839480A (en) * | 1971-09-30 | 1973-06-09 | ||
JPS50130769A (en) * | 1974-04-03 | 1975-10-16 | ||
JPS5283667A (en) * | 1976-01-01 | 1977-07-12 | Boehringer Sohn Ingelheim | Novel 5*9bb2 substituted 22tetrahydrofurfuryll 6*77benzomorphane and medical compositions containing same |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0415634A2 (en) * | 1989-08-30 | 1991-03-06 | Pfizer Inc. | Benzazabicyclic carbamates as cholinesterase inhibitors |
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