JPS5625164A - Tetrahydroisoquinoline compound and its preparation - Google Patents

Tetrahydroisoquinoline compound and its preparation

Info

Publication number
JPS5625164A
JPS5625164A JP10151379A JP10151379A JPS5625164A JP S5625164 A JPS5625164 A JP S5625164A JP 10151379 A JP10151379 A JP 10151379A JP 10151379 A JP10151379 A JP 10151379A JP S5625164 A JPS5625164 A JP S5625164A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
tetrahydroisoquinoline
incorporate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10151379A
Other languages
Japanese (ja)
Other versions
JPS6320229B2 (en
Inventor
Yoshikazu Oka
Kohei Nishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP10151379A priority Critical patent/JPS5625164A/en
Priority to EP19800300933 priority patent/EP0018104B1/en
Priority to DE8080300933T priority patent/DE3063420D1/en
Priority to AT80300933T priority patent/ATE3546T1/en
Publication of JPS5625164A publication Critical patent/JPS5625164A/en
Publication of JPS6320229B2 publication Critical patent/JPS6320229B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Tetrahydroisoquinoline compounds of formula I (R1 and R2 are H, hydroxyl, lower alkyl, lower alkyloxy, the two adjacent groups may incorporate to form a ring; R3 and R4 are H, lower alkyl; R5 and R6 are H, acyl or incorporate to represent one single bond).
EXAMPLE: ( S )-2-( 3-Acetylthio-2-acetylthiomethylpropionyl )-6,7-dihydroxy-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid.
USE: They are used for diagnosis, prophylaxis and treatment of hyperpiesia, because they show activity of inhibiting angiotensin-transforming enzyme and bradykinin- decomposing enzyme in animals, in particular, mammalians. They are also low- toxicity.
PREPARATION: A compound of formula II is made to react with a compound of formula III or its derivative activated in the carboxy group to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP10151379A 1979-03-26 1979-08-08 Tetrahydroisoquinoline compound and its preparation Granted JPS5625164A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP10151379A JPS5625164A (en) 1979-08-08 1979-08-08 Tetrahydroisoquinoline compound and its preparation
EP19800300933 EP0018104B1 (en) 1979-03-26 1980-03-25 Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
DE8080300933T DE3063420D1 (en) 1979-03-26 1980-03-25 Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
AT80300933T ATE3546T1 (en) 1979-03-26 1980-03-25 TETRAHYDROISOCHINOLINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR USE IN THE PREVENTION AND TREATMENT OF HIGH BLOOD PRESSURE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10151379A JPS5625164A (en) 1979-08-08 1979-08-08 Tetrahydroisoquinoline compound and its preparation

Publications (2)

Publication Number Publication Date
JPS5625164A true JPS5625164A (en) 1981-03-10
JPS6320229B2 JPS6320229B2 (en) 1988-04-26

Family

ID=14302626

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10151379A Granted JPS5625164A (en) 1979-03-26 1979-08-08 Tetrahydroisoquinoline compound and its preparation

Country Status (1)

Country Link
JP (1) JPS5625164A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60179104A (en) * 1984-02-27 1985-09-13 Nippon Atom Ind Group Co Ltd Process for operating filtration apparatus comprising hollow yarn membrane

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60179104A (en) * 1984-02-27 1985-09-13 Nippon Atom Ind Group Co Ltd Process for operating filtration apparatus comprising hollow yarn membrane
JPH0536089B2 (en) * 1984-02-27 1993-05-28 Tokyo Shibaura Electric Co

Also Published As

Publication number Publication date
JPS6320229B2 (en) 1988-04-26

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