JPS5625164A - Tetrahydroisoquinoline compound and its preparation - Google Patents
Tetrahydroisoquinoline compound and its preparationInfo
- Publication number
- JPS5625164A JPS5625164A JP10151379A JP10151379A JPS5625164A JP S5625164 A JPS5625164 A JP S5625164A JP 10151379 A JP10151379 A JP 10151379A JP 10151379 A JP10151379 A JP 10151379A JP S5625164 A JPS5625164 A JP S5625164A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- tetrahydroisoquinoline
- incorporate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Tetrahydroisoquinoline compounds of formula I (R1 and R2 are H, hydroxyl, lower alkyl, lower alkyloxy, the two adjacent groups may incorporate to form a ring; R3 and R4 are H, lower alkyl; R5 and R6 are H, acyl or incorporate to represent one single bond).
EXAMPLE: ( S )-2-( 3-Acetylthio-2-acetylthiomethylpropionyl )-6,7-dihydroxy-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid.
USE: They are used for diagnosis, prophylaxis and treatment of hyperpiesia, because they show activity of inhibiting angiotensin-transforming enzyme and bradykinin- decomposing enzyme in animals, in particular, mammalians. They are also low- toxicity.
PREPARATION: A compound of formula II is made to react with a compound of formula III or its derivative activated in the carboxy group to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10151379A JPS5625164A (en) | 1979-08-08 | 1979-08-08 | Tetrahydroisoquinoline compound and its preparation |
EP19800300933 EP0018104B1 (en) | 1979-03-26 | 1980-03-25 | Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension |
DE8080300933T DE3063420D1 (en) | 1979-03-26 | 1980-03-25 | Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension |
AT80300933T ATE3546T1 (en) | 1979-03-26 | 1980-03-25 | TETRAHYDROISOCHINOLINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR USE IN THE PREVENTION AND TREATMENT OF HIGH BLOOD PRESSURE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10151379A JPS5625164A (en) | 1979-08-08 | 1979-08-08 | Tetrahydroisoquinoline compound and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5625164A true JPS5625164A (en) | 1981-03-10 |
JPS6320229B2 JPS6320229B2 (en) | 1988-04-26 |
Family
ID=14302626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10151379A Granted JPS5625164A (en) | 1979-03-26 | 1979-08-08 | Tetrahydroisoquinoline compound and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5625164A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60179104A (en) * | 1984-02-27 | 1985-09-13 | Nippon Atom Ind Group Co Ltd | Process for operating filtration apparatus comprising hollow yarn membrane |
-
1979
- 1979-08-08 JP JP10151379A patent/JPS5625164A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60179104A (en) * | 1984-02-27 | 1985-09-13 | Nippon Atom Ind Group Co Ltd | Process for operating filtration apparatus comprising hollow yarn membrane |
JPH0536089B2 (en) * | 1984-02-27 | 1993-05-28 | Tokyo Shibaura Electric Co |
Also Published As
Publication number | Publication date |
---|---|
JPS6320229B2 (en) | 1988-04-26 |
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