ES2010471A6 - Procedimiento de preparar nuevos derivados de los acidos 1,4-dihidro-4-oxoquinolein-3-carboxilicos. - Google Patents
Procedimiento de preparar nuevos derivados de los acidos 1,4-dihidro-4-oxoquinolein-3-carboxilicos.Info
- Publication number
- ES2010471A6 ES2010471A6 ES8901094A ES8901094A ES2010471A6 ES 2010471 A6 ES2010471 A6 ES 2010471A6 ES 8901094 A ES8901094 A ES 8901094A ES 8901094 A ES8901094 A ES 8901094A ES 2010471 A6 ES2010471 A6 ES 2010471A6
- Authority
- ES
- Spain
- Prior art keywords
- difluoro
- imidazolyl
- medicaments
- cyclopropyl
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SFKCXXOFJCTFEE-UHFFFAOYSA-N 1-cyclopropyl-6,8-difluoro-7-imidazol-1-yl-4-oxoquinoline-2-carboxylic acid Chemical class OC(=O)C1=CC(=O)C2=CC(F)=C(N3C=NC=C3)C(F)=C2N1C1CC1 SFKCXXOFJCTFEE-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- -1 alkyl radical Chemical class 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARAR NUEVOS DERIVADOS DE LOS ACIDOS 1,4-DIHIDRO-4-OXOQUINOLEIN-3-CARBOXILICOS, QUE RESPONDEN A LA FORMULA GENERAL (I) DONDE: R REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO INFERIOR O UN RADICAL FENILO O FENILO SUSTITUIDO, Y R1 REPRESENTA UN RADICAL ALQUILO O UN RADICAL ARILO, ASI COMO SUS SALES FISIOLOGICAMENTE ACEPTABLES, QUE CONSISTE EN HACER REACCIONAR UN COMPUESTO HETEROCICLICO DE FORMULA (II), CON UN IMIDAZOL DE FORMULA (III), SEGUN SE EXPLICA EN LA MEMORIA. SE UTILIZAN EN MEDICINA HUMANA Y VETERINARIA PARA EL TRATAMIENTO DE INFECCIONES CAUSADAS POR MICROORGANISMOS GRAM-POSITIVOS Y GRAM-NEGATIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8804289A FR2629456B1 (fr) | 1988-03-31 | 1988-03-31 | Derives des acides 7-(1-imidazolyl),1,4-dihydro-4-oxo-6,8-difluoro-1-cyclopropyl-3-quinoleincarboxylique, leur preparation et leur application en tant que medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2010471A6 true ES2010471A6 (es) | 1989-11-01 |
Family
ID=9364848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8901094A Expired ES2010471A6 (es) | 1988-03-31 | 1989-03-29 | Procedimiento de preparar nuevos derivados de los acidos 1,4-dihidro-4-oxoquinolein-3-carboxilicos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5098913A (es) |
EP (1) | EP0340055B1 (es) |
AT (1) | ATE86620T1 (es) |
AU (1) | AU618794B2 (es) |
DE (1) | DE68905222T2 (es) |
ES (1) | ES2010471A6 (es) |
FR (1) | FR2629456B1 (es) |
GR (1) | GR3007320T3 (es) |
NZ (1) | NZ228515A (es) |
ZA (1) | ZA892312B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59128383A (ja) * | 1982-12-29 | 1984-07-24 | Kanebo Ltd | 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤 |
FR2574404B1 (fr) * | 1984-12-12 | 1987-04-24 | Provesan Sa | Derives 1-substitues de l'acide 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoleine-3-carboxylique, leur preparation et leur application en tant que medicaments |
DE3519286A1 (de) * | 1985-05-30 | 1986-12-04 | Bayer Ag, 5090 Leverkusen | 7-azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3- chinolincarbonsaeuren und -1,8-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
-
1988
- 1988-03-31 FR FR8804289A patent/FR2629456B1/fr not_active Expired - Lifetime
-
1989
- 1989-03-29 ES ES8901094A patent/ES2010471A6/es not_active Expired
- 1989-03-29 ZA ZA892312A patent/ZA892312B/xx unknown
- 1989-03-29 AT AT89400873T patent/ATE86620T1/de not_active IP Right Cessation
- 1989-03-29 DE DE8989400873T patent/DE68905222T2/de not_active Expired - Fee Related
- 1989-03-29 NZ NZ228515A patent/NZ228515A/en unknown
- 1989-03-29 EP EP89400873A patent/EP0340055B1/fr not_active Expired - Lifetime
- 1989-03-31 AU AU32263/89A patent/AU618794B2/en not_active Ceased
-
1991
- 1991-02-08 US US07/653,856 patent/US5098913A/en not_active Expired - Fee Related
-
1993
- 1993-03-11 GR GR930400396T patent/GR3007320T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU3226389A (en) | 1989-10-05 |
US5098913A (en) | 1992-03-24 |
DE68905222D1 (de) | 1993-04-15 |
FR2629456A1 (fr) | 1989-10-06 |
NZ228515A (en) | 1990-10-26 |
ZA892312B (en) | 1989-12-27 |
FR2629456B1 (fr) | 1991-07-05 |
EP0340055A1 (fr) | 1989-11-02 |
EP0340055B1 (fr) | 1993-03-10 |
ATE86620T1 (de) | 1993-03-15 |
GR3007320T3 (es) | 1993-07-30 |
AU618794B2 (en) | 1992-01-09 |
DE68905222T2 (de) | 1993-06-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |