ES2006623A6 - Procedimiento de preparacion de nuevos derivados de amino 5,6,7,8-tetrahidro-(2,3b)-nafto-furano. - Google Patents

Procedimiento de preparacion de nuevos derivados de amino 5,6,7,8-tetrahidro-(2,3b)-nafto-furano.

Info

Publication number
ES2006623A6
ES2006623A6 ES8801011A ES8801011A ES2006623A6 ES 2006623 A6 ES2006623 A6 ES 2006623A6 ES 8801011 A ES8801011 A ES 8801011A ES 8801011 A ES8801011 A ES 8801011A ES 2006623 A6 ES2006623 A6 ES 2006623A6
Authority
ES
Spain
Prior art keywords
radical
carbon atoms
linear
amino
denotes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801011A
Other languages
English (en)
Inventor
Jean-Louis Peglion
Jean-Claude Poigmant
Joel Vian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES2006623A6 publication Critical patent/ES2006623A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS DE AMINO-5,6,7,8-TETRAHIDRO-(2,3B)-NAFTO-FURANO. PROCEDIMIENTO DE PREPARACION DE NUEVOS COMPUESTOS DE FORMULA GENERAL I, EN LA QUE R1, R2, R3 Y R4 REPRESENTAN DIVERSOS RESTOS ALQUILICOS, CICLOALQUILICOS O AROMATICOS, EVENTUALMENTE SUSTITUIDOS, CARACTERIZADO PORQUE BIEN PARTIENDO DE 2,3-DIHIDROBENZOFURANO, SE OBTIENE 5,6,7,8-TETRAHIDRO-(2,3B)-NAFTO-2,3-DIHIDRO-8-FURANONA, POR CONDENSACION CON ANHIDRIDO SUCCINICO, SEGUIDA DE HIDROGENACION Y CICLACION, QUE OPTATIVAMENTE SE TRATA CON HIDROXILAMINA, BROMACION O REDUCCION, EN FUNCION DE LA POSICION DESEADA DEL RADICAL AMINO Y FINALMENTE SE ALCOHOLIZAN, O BIEN PARTIENDO DE 2,7-DIMETOXINAFTALENO, POR TRATAMIENTO SUCESIVO CON SODIO METALICO, HIDROXILAMINA, HIDROGENACION, ANHIDRIDO ACETICO Y TRIETILAMINA, CONDUCE A 7-ACETAMIDO-5,6,7,8-TETRAHIDRO-(2,3B)-NAFTO-2,3-DIHIDRO-3-FURANONA, QUE SOMETIDA A LA ACCION DE UNA BASE MINERAL Y ALCOHOLACION, O BIEN MEDIANTE REDUCCION, TRATAMIENTO CON ACIDO O BASE FUERTE Y ALCOHOLACION, CONDUCE A LOS COMPUESTOS DESEADOS. LOS COMPUESTOS ASI OBTENIDOS POSEEN IMPORTANTES PROPIEDADES ANTIDEPRESIVAS, PSICOESTIMULANTES Y DOPAMINERGICAS. MEDICAMENTOS.
ES8801011A 1987-04-01 1988-03-30 Procedimiento de preparacion de nuevos derivados de amino 5,6,7,8-tetrahidro-(2,3b)-nafto-furano. Expired ES2006623A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8704551A FR2613365B1 (fr) 1987-04-01 1987-04-01 Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2006623A6 true ES2006623A6 (es) 1989-05-01

Family

ID=9349665

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8801011A Expired ES2006623A6 (es) 1987-04-01 1988-03-30 Procedimiento de preparacion de nuevos derivados de amino 5,6,7,8-tetrahidro-(2,3b)-nafto-furano.

Country Status (16)

Country Link
US (2) US4863951A (es)
EP (1) EP0286516B1 (es)
JP (1) JPH068286B2 (es)
AT (1) ATE73790T1 (es)
AU (1) AU602565B2 (es)
CA (1) CA1314050C (es)
DE (1) DE3869173D1 (es)
DK (1) DK166496B1 (es)
ES (1) ES2006623A6 (es)
FR (1) FR2613365B1 (es)
GR (1) GR1000155B (es)
IE (1) IE61007B1 (es)
NZ (1) NZ224099A (es)
OA (1) OA08825A (es)
PT (1) PT87147B (es)
ZA (1) ZA882282B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613364B1 (fr) * 1987-04-01 1989-06-09 Adir Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2689509B1 (fr) * 1992-04-01 1994-06-03 Adir Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
EP0690843B1 (en) * 1993-03-25 2000-08-30 PHARMACIA & UPJOHN COMPANY Formyl- or cyano- substituted indole derivatives having dopaminergic activity
WO1996003396A1 (en) * 1994-07-27 1996-02-08 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5998461A (en) * 1994-10-21 1999-12-07 Adir Et Compagnie Tricyclic amide compounds
US6071946A (en) * 1994-10-21 2000-06-06 Adir Et Compagnie Tricyclic urea compounds
FR2725985B1 (fr) * 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2739379B1 (fr) * 1995-09-29 1997-10-24 Adir Nouveaux composes amines de 5,6,7,8-tetrahydronaphto(2,3-b) furane et d'indano(5,6-b)furane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2739855B1 (fr) * 1995-10-13 1997-11-14 Adir Nouvelles amines heterocycliques tertiaires, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DK2123265T3 (da) * 2008-05-23 2012-09-03 Novaera S R L Endipalenformuleringer til behandling af psoriasis
JP5701213B2 (ja) 2008-10-10 2015-04-15 インスティチュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ 新規なドーパミンｄ３受容体リガンド、その調製及び使用
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1084439A (en) * 1963-12-31 1967-09-20 Upjohn Co Improvements in or relating to heteroeyclic compounds and the manufacture thereof
US4470990A (en) * 1983-03-14 1984-09-11 Ayerst, Mckenna & Harrison Inc. 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants
FR2613364B1 (fr) * 1987-04-01 1989-06-09 Adir Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
EP0286516A1 (fr) 1988-10-12
IE880971L (en) 1988-10-01
DE3869173D1 (de) 1992-04-23
ATE73790T1 (de) 1992-04-15
DK166496B1 (da) 1993-06-01
AU602565B2 (en) 1990-10-18
JPH068286B2 (ja) 1994-02-02
AU1404988A (en) 1988-10-06
FR2613365A1 (fr) 1988-10-07
FR2613365B1 (fr) 1989-07-28
PT87147A (pt) 1988-04-01
GR1000155B (el) 1991-09-27
US4863951A (en) 1989-09-05
PT87147B (pt) 1992-07-31
OA08825A (fr) 1989-03-31
DK178488D0 (da) 1988-03-30
IE61007B1 (en) 1994-09-07
JPS63258870A (ja) 1988-10-26
CA1314050C (fr) 1993-03-02
DK178488A (da) 1988-10-02
NZ224099A (en) 1990-05-28
ZA882282B (en) 1988-09-22
GR880100208A (en) 1989-01-31
US4885373A (en) 1989-12-05
EP0286516B1 (fr) 1992-03-18

Similar Documents

Publication Publication Date Title
ES2006623A6 (es) Procedimiento de preparacion de nuevos derivados de amino 5,6,7,8-tetrahidro-(2,3b)-nafto-furano.
GB2183647B (es)
IL108562A (en) 7, 8-diaryl-1,2,3,4- terahydropyrazolo- £5,1-c| £1,2,4| triazine derivatives, methods for the preparation thereof and pharmaceutical compositions containing them
ATE289602T1 (de) Quinolin-2-on-derivate verwendbar als antikrebsmittel
MX9800577A (es) Derivados de 4,5-diaril oxazol.
NZ235658A (en) Anthraquinone derivatives containing at least one n'-disubstituted n'-oxide alkylamino substituent; preparatory processes and intermediates
IL103944A0 (en) Piperazine derivatives,their preparation and pharmaceutical compositions containing them
IL75273A (en) Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them
ES2006622A6 (es) Procedimiento de preparacion de nuevas aminas triciclicas derivadas del 5,6,7,8-tetrahidro-(2,3b)-nafto-2,3-dihidrofurano, y de 6,7,8,9-tetrahidro-(2,3b)-5h-benzociclohepta-2,3-dihidro-furano.
ES8801266A1 (es) Un procedimiento para preparar nuevos compuestos heterociclicos condensados con benceno
IL111725A0 (en) 3'-aziridino-anthracycline derivatives, their preparation and pharmaceutical compositions containing them
ES2075429T3 (es) Derivados de 4,5-cicloalcano-3-benzazepin-7-ol y sus usos.
NZ218404A (en) Cephalosporin derivatives and pharmaceutical compositions
IL87796A0 (en) Substituted 3-aminosydnonimines,their preparation and pharmaceutical compositions containing them
EP0370902A3 (en) Use of chromane derivatives in the treatment of depressive conditions
DE3373302D1 (en) Derivatives of aminopyridinecarboxylic acids, methods for their preparation and pharmaceutical compositions containing them
YU135887A (en) Process for obtaining new tetracyclic derivatives of indole
ES2006336A6 (es) Procedimiento de preparacion de nuevas acetamidas derivadas de la 2,3-dihidro-3-fenil-2-benzofuranona.
HUT53093A (en) Process for producing substituted 3-amino-sidnonimine derivatives and pharmaceutical compositions them as active components
ES8800230A1 (es) Un procedimiento para preparar compuestos heterociclicos fusionados con benceno

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301