ES2005059B3 - Nuevo procedimiento de preparacion de fibratos. - Google Patents

Nuevo procedimiento de preparacion de fibratos.

Info

Publication number
ES2005059B3
ES2005059B3 ES87400967T ES87400967T ES2005059B3 ES 2005059 B3 ES2005059 B3 ES 2005059B3 ES 87400967 T ES87400967 T ES 87400967T ES 87400967 T ES87400967 T ES 87400967T ES 2005059 B3 ES2005059 B3 ES 2005059B3
Authority
ES
Spain
Prior art keywords
fibrates
preparation
new procedure
image
halogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87400967T
Other languages
English (en)
Spanish (es)
Other versions
ES2005059A4 (es
Inventor
Jean-Pierre Bourgogne
Roland Sornay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Innovation et Synergie SA
Original Assignee
Fournier Innovation et Synergie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9334781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2005059(B3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fournier Innovation et Synergie SA filed Critical Fournier Innovation et Synergie SA
Publication of ES2005059A4 publication Critical patent/ES2005059A4/es
Application granted granted Critical
Publication of ES2005059B3 publication Critical patent/ES2005059B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Drilling Tools (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
ES87400967T 1986-04-30 1987-04-27 Nuevo procedimiento de preparacion de fibratos. Expired - Lifetime ES2005059B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8606258A FR2598146B1 (fr) 1986-04-30 1986-04-30 Nouveau procede de preparation de fibrates.

Publications (2)

Publication Number Publication Date
ES2005059A4 ES2005059A4 (es) 1989-03-01
ES2005059B3 true ES2005059B3 (es) 1990-03-16

Family

ID=9334781

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87400967T Expired - Lifetime ES2005059B3 (es) 1986-04-30 1987-04-27 Nuevo procedimiento de preparacion de fibratos.

Country Status (9)

Country Link
US (1) US4739101A (OSRAM)
EP (1) EP0245156B1 (OSRAM)
JP (1) JPS62263146A (OSRAM)
AT (1) ATE49195T1 (OSRAM)
CA (1) CA1282424C (OSRAM)
DE (1) DE3761307D1 (OSRAM)
ES (1) ES2005059B3 (OSRAM)
FR (1) FR2598146B1 (OSRAM)
GR (1) GR3000418T3 (OSRAM)

Families Citing this family (44)

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JPH0725725B2 (ja) * 1987-07-23 1995-03-22 保土谷化学工業株式会社 ベンズアミド誘導体
WO1989006643A1 (fr) * 1988-01-22 1989-07-27 Kharkovsky Nauchno-Issledovatelsky Institut Endokr ACIDE n-CHLOROPHENOXYISOBUTIRIQUE D'ETHER UNDECYLIQUE ET PREPARATION PHARMACEUTIQUE LE CONTENANT POUR TRAITER L'HYPERLIPEMIE
US5008439A (en) * 1988-03-21 1991-04-16 Hoechst Celanese Corporation Synthesis of 2-(4-hydroxyphenoxy) alkanoic acid esters
IL102707A (en) * 1992-08-02 1996-11-14 Cherkez Stephen Processes for the preparation of tyramine derivatives
DE59307210D1 (de) * 1993-05-12 1997-10-02 Heumann Pharma Gmbh & Co Stabile und kristalline Form von Bezafibrat
US5412112A (en) * 1994-06-14 1995-05-02 Industrial Technology Research Institute Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids
US7014864B1 (en) 1998-12-18 2006-03-21 Abbott Laboratories Formulations comprising lipid-regulating agents
US6814977B1 (en) 1998-12-18 2004-11-09 Abbott Laboratories Formulations comprising lipid-regulating agents
US6838091B2 (en) * 1998-12-18 2005-01-04 Abbott Laboratories Formulations comprising lipid-regulating agents
US6180138B1 (en) 1999-01-29 2001-01-30 Abbott Laboratories Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption
US6368622B2 (en) 1999-01-29 2002-04-09 Abbott Laboratories Process for preparing solid formulations of lipid regulating agents with enhanced dissolution and absorption
US6383517B1 (en) 1999-01-29 2002-05-07 Abbott Laboratories Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption
US6719999B2 (en) 1999-03-31 2004-04-13 Abbott Laboratories Formulations comprising lipid-regulating agents
US6372251B2 (en) 1999-06-11 2002-04-16 Abbott Laboratories Formulations comprising lipid-regulating agents
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
NZ542090A (en) * 2001-01-26 2006-09-29 Schering Corp Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
MEP27808A (en) * 2001-01-26 2010-10-10 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
PT1355644E (pt) * 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
NZ545332A (en) * 2001-01-26 2007-09-28 Schering Corp Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
WO2002058733A2 (en) * 2001-01-26 2002-08-01 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
TW200840563A (en) * 2001-01-26 2008-10-16 Schering Corp Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications
ITMI20010203A1 (it) * 2001-02-02 2002-08-02 Solchem Italiana Spa Processo per la preparazione di fibrati
ITMI20010936A1 (it) * 2001-05-08 2002-11-08 Laboratorio Chimico Int Spa Processo per la produzione di acidi 2-4-(2,2-dialociclopropil)fenossi|-alcanoici e loro esteri
DE60216275T2 (de) * 2001-05-25 2007-06-21 Schering Corp. Verwendung von mit azetidinon substituierten derivaten bei der behandlung der alzheimer-krankheit
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7132415B2 (en) * 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
MXPA04002572A (es) * 2001-09-21 2004-05-31 Schering Corp Metodos para el tratamiento o prevencion de inflamacion vascular usando inhibidores de absorcion de esterol.
CA2504878A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
WO2004081002A1 (en) * 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
WO2004081003A1 (en) * 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2544309A1 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US8062664B2 (en) * 2003-11-12 2011-11-22 Abbott Laboratories Process for preparing formulations of lipid-regulating drugs
FR2892721B1 (fr) * 2005-10-28 2009-07-24 Synkem Sa Nouveau procede de preparation de sels d'acides et d'ammonium quaternaires
EP1837327A1 (en) * 2006-03-23 2007-09-26 SOLMAG S.p.A. Method for preparing pure fenofibrate
EP2173701A1 (fr) * 2007-07-05 2010-04-14 Finorga Procede de preparation du fenofibrate
CN103373921B (zh) 2012-04-26 2016-08-10 浙江海正药业股份有限公司 4-((取代苯基)二氟甲基)苯氧基羧酸衍生物及其制备方法和医药用途
US11427528B2 (en) 2016-07-29 2022-08-30 Hangzhou Solipharma Co., Ltd. Fenofibrate crystalline form and manufacturing method thereof
CN107698422A (zh) * 2017-08-21 2018-02-16 赵剑锋 一种2‑[4‑(4‑ 氯苯甲酰) 苯氧基]‑2‑ 甲基丙酸的合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060573A1 (de) * 1969-12-18 1971-06-24 Ciba Geigy Ag Neue Carbonsaeuren und Verfahren zu ihrer Herstellung
US3795691A (en) * 1971-06-23 1974-03-05 American Home Prod Cholesterol-lowering agents
US3759950A (en) * 1971-09-20 1973-09-18 American Home Prod 2-phenoxyalkanoic acid esters
CH626318A5 (OSRAM) * 1977-03-08 1981-11-13 Ciba Geigy Ag
IT1141655B (it) * 1980-02-12 1986-10-08 Schiapparelli Spa Nuovi derivati dell'acido propanoico ad attivita' ipolipidemica e ipocolesterolemica
DE3150233A1 (de) * 1981-12-18 1983-06-30 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-(hydroxiphenoxi)-carbonsaeureestern
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
IL71668A (en) * 1983-05-13 1988-07-31 Dow Chemical Co Method of preparing esters of aryloxyphenoxy propanoic acid

Also Published As

Publication number Publication date
GR3000418T3 (en) 1991-06-28
ATE49195T1 (de) 1990-01-15
ES2005059A4 (es) 1989-03-01
FR2598146B1 (fr) 1989-01-20
JPH0529343B2 (OSRAM) 1993-04-30
DE3761307D1 (de) 1990-02-08
EP0245156B1 (fr) 1990-01-03
US4739101A (en) 1988-04-19
JPS62263146A (ja) 1987-11-16
EP0245156A1 (fr) 1987-11-11
FR2598146A1 (fr) 1987-11-06
CA1282424C (en) 1991-04-02

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