ES2005059B3 - Nuevo procedimiento de preparacion de fibratos. - Google Patents
Nuevo procedimiento de preparacion de fibratos.Info
- Publication number
- ES2005059B3 ES2005059B3 ES87400967T ES87400967T ES2005059B3 ES 2005059 B3 ES2005059 B3 ES 2005059B3 ES 87400967 T ES87400967 T ES 87400967T ES 87400967 T ES87400967 T ES 87400967T ES 2005059 B3 ES2005059 B3 ES 2005059B3
- Authority
- ES
- Spain
- Prior art keywords
- fibrates
- preparation
- new procedure
- image
- halogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Sampling And Sample Adjustment (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Drilling Tools (AREA)
- Polishing Bodies And Polishing Tools (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8606258A FR2598146B1 (fr) | 1986-04-30 | 1986-04-30 | Nouveau procede de preparation de fibrates. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2005059A4 ES2005059A4 (es) | 1989-03-01 |
ES2005059B3 true ES2005059B3 (es) | 1990-03-16 |
Family
ID=9334781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87400967T Expired - Lifetime ES2005059B3 (es) | 1986-04-30 | 1987-04-27 | Nuevo procedimiento de preparacion de fibratos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4739101A (es) |
EP (1) | EP0245156B1 (es) |
JP (1) | JPS62263146A (es) |
AT (1) | ATE49195T1 (es) |
CA (1) | CA1282424C (es) |
DE (1) | DE3761307D1 (es) |
ES (1) | ES2005059B3 (es) |
FR (1) | FR2598146B1 (es) |
GR (1) | GR3000418T3 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0725725B2 (ja) * | 1987-07-23 | 1995-03-22 | 保土谷化学工業株式会社 | ベンズアミド誘導体 |
GB2221681A (en) * | 1988-01-22 | 1990-02-14 | Kh Nii Endokrinolog I Khim | Undecylic ether n-chlorophenoxyisobutyric acid and a pharmaceutical preparation for treating hyperlipemia based on it |
US5008439A (en) * | 1988-03-21 | 1991-04-16 | Hoechst Celanese Corporation | Synthesis of 2-(4-hydroxyphenoxy) alkanoic acid esters |
IL102707A (en) * | 1992-08-02 | 1996-11-14 | Cherkez Stephen | Processes for the preparation of tyramine derivatives |
ATE157349T1 (de) | 1993-05-12 | 1997-09-15 | Heumann Pharma Gmbh & Co | Stabile und kristalline form von bezafibrat |
US5412112A (en) * | 1994-06-14 | 1995-05-02 | Industrial Technology Research Institute | Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids |
US7014864B1 (en) | 1998-12-18 | 2006-03-21 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6814977B1 (en) | 1998-12-18 | 2004-11-09 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6838091B2 (en) * | 1998-12-18 | 2005-01-04 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6368622B2 (en) | 1999-01-29 | 2002-04-09 | Abbott Laboratories | Process for preparing solid formulations of lipid regulating agents with enhanced dissolution and absorption |
US6383517B1 (en) | 1999-01-29 | 2002-05-07 | Abbott Laboratories | Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption |
US6180138B1 (en) | 1999-01-29 | 2001-01-30 | Abbott Laboratories | Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption |
US6719999B2 (en) | 1999-03-31 | 2004-04-13 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6372251B2 (en) | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
KR100820983B1 (ko) * | 2001-01-26 | 2008-04-10 | 쉐링 코포레이션 | 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물 |
BR0206644A (pt) * | 2001-01-26 | 2004-02-25 | Schering Corp | Combinações de inibidor(es) de absorção de esteróis com agente(s) cardiovascular(es) para o tratamento de condições vasculares |
CN1658903A (zh) * | 2001-01-26 | 2005-08-24 | 先灵公司 | 用于治疗血管性疾病的固醇吸收抑制剂与血液调节剂的组合 |
KR100596257B1 (ko) * | 2001-01-26 | 2006-07-03 | 쉐링 코포레이션 | 스테롤 흡수 억제제를 포함하는 조성물, 및 페록시솜 증식인자-활성화 수용체 활성화제와 스테롤 흡수 억제제를 포함하는 조성물 및 조합물 |
ATE369851T1 (de) * | 2001-01-26 | 2007-09-15 | Schering Corp | Kombinationen von gallensäuresequestriermitteln und hemmern der sterolabsorption zur behandlung von kardiovaskulären indikationen |
US20020183305A1 (en) * | 2001-01-26 | 2002-12-05 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
ITMI20010203A1 (it) * | 2001-02-02 | 2002-08-02 | Solchem Italiana Spa | Processo per la preparazione di fibrati |
ITMI20010936A1 (it) * | 2001-05-08 | 2002-11-08 | Laboratorio Chimico Int Spa | Processo per la produzione di acidi 2-4-(2,2-dialociclopropil)fenossi|-alcanoici e loro esteri |
AR038956A1 (es) * | 2001-05-25 | 2005-02-02 | Schering Corp | Uso de un compuesto que regula la produccion o niveles de peptidos beta amiloides para la manufactura de un medicamento para tratar la enfermedad de alzheimer y/o para regular dichos niveles de peptidos amiloides beta en un sujeto |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
CA2460340C (en) * | 2001-09-21 | 2011-02-15 | Schering Corporation | Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
MXPA04002572A (es) * | 2001-09-21 | 2004-05-31 | Schering Corp | Metodos para el tratamiento o prevencion de inflamacion vascular usando inhibidores de absorcion de esterol. |
AU2003291719A1 (en) * | 2002-11-06 | 2004-06-03 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
CA2517573C (en) | 2003-03-07 | 2011-12-06 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
DE602004016123D1 (de) * | 2003-03-07 | 2008-10-09 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
ATE418551T1 (de) * | 2003-03-07 | 2009-01-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
US20050096307A1 (en) * | 2003-11-05 | 2005-05-05 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
US8062664B2 (en) * | 2003-11-12 | 2011-11-22 | Abbott Laboratories | Process for preparing formulations of lipid-regulating drugs |
FR2892721B1 (fr) * | 2005-10-28 | 2009-07-24 | Synkem Sa | Nouveau procede de preparation de sels d'acides et d'ammonium quaternaires |
EP1837327A1 (en) * | 2006-03-23 | 2007-09-26 | SOLMAG S.p.A. | Method for preparing pure fenofibrate |
CN101730675A (zh) * | 2007-07-05 | 2010-06-09 | 菲诺格拉公司 | 制备非诺贝特的方法 |
CN103373921B (zh) | 2012-04-26 | 2016-08-10 | 浙江海正药业股份有限公司 | 4-((取代苯基)二氟甲基)苯氧基羧酸衍生物及其制备方法和医药用途 |
WO2018018618A1 (zh) * | 2016-07-29 | 2018-02-01 | 浙江工业大学 | 一种非诺贝特的晶型及其制备方法 |
CN107698422A (zh) * | 2017-08-21 | 2018-02-16 | 赵剑锋 | 一种2‑[4‑(4‑ 氯苯甲酰) 苯氧基]‑2‑ 甲基丙酸的合成工艺 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2060573A1 (de) * | 1969-12-18 | 1971-06-24 | Ciba Geigy Ag | Neue Carbonsaeuren und Verfahren zu ihrer Herstellung |
US3795691A (en) * | 1971-06-23 | 1974-03-05 | American Home Prod | Cholesterol-lowering agents |
US3759950A (en) * | 1971-09-20 | 1973-09-18 | American Home Prod | 2-phenoxyalkanoic acid esters |
CH626318A5 (es) * | 1977-03-08 | 1981-11-13 | Ciba Geigy Ag | |
IT1141655B (it) * | 1980-02-12 | 1986-10-08 | Schiapparelli Spa | Nuovi derivati dell'acido propanoico ad attivita' ipolipidemica e ipocolesterolemica |
DE3150233A1 (de) * | 1981-12-18 | 1983-06-30 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von 2-(hydroxiphenoxi)-carbonsaeureestern |
US4661505A (en) * | 1982-11-03 | 1987-04-28 | Eli Lilly And Company | Leukotriene antagonists |
IL71668A (en) * | 1983-05-13 | 1988-07-31 | Dow Chemical Co | Method of preparing esters of aryloxyphenoxy propanoic acid |
-
1986
- 1986-04-30 FR FR8606258A patent/FR2598146B1/fr not_active Expired
-
1987
- 1987-04-27 AT AT87400967T patent/ATE49195T1/de not_active IP Right Cessation
- 1987-04-27 EP EP87400967A patent/EP0245156B1/fr not_active Expired - Lifetime
- 1987-04-27 DE DE8787400967T patent/DE3761307D1/de not_active Expired - Lifetime
- 1987-04-27 US US07/043,184 patent/US4739101A/en not_active Expired - Lifetime
- 1987-04-27 CA CA000535685A patent/CA1282424C/en not_active Expired - Lifetime
- 1987-04-27 ES ES87400967T patent/ES2005059B3/es not_active Expired - Lifetime
- 1987-04-28 JP JP62106179A patent/JPS62263146A/ja active Granted
-
1990
- 1990-03-30 GR GR90400186T patent/GR3000418T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0529343B2 (es) | 1993-04-30 |
DE3761307D1 (de) | 1990-02-08 |
FR2598146A1 (fr) | 1987-11-06 |
CA1282424C (en) | 1991-04-02 |
FR2598146B1 (fr) | 1989-01-20 |
US4739101A (en) | 1988-04-19 |
GR3000418T3 (en) | 1991-06-28 |
ES2005059A4 (es) | 1989-03-01 |
EP0245156A1 (fr) | 1987-11-11 |
ATE49195T1 (de) | 1990-01-15 |
EP0245156B1 (fr) | 1990-01-03 |
JPS62263146A (ja) | 1987-11-16 |
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