ES2004845A4 - Flavonoides sinteticos como inhibidores de leucotrienos y 5-lipoxigenasa. - Google Patents

Flavonoides sinteticos como inhibidores de leucotrienos y 5-lipoxigenasa.

Info

Publication number
ES2004845A4
ES2004845A4 ES88106495T ES88106495T ES2004845A4 ES 2004845 A4 ES2004845 A4 ES 2004845A4 ES 88106495 T ES88106495 T ES 88106495T ES 88106495 T ES88106495 T ES 88106495T ES 2004845 A4 ES2004845 A4 ES 2004845A4
Authority
ES
Spain
Prior art keywords
leucotrene
lipoxigenase
synthetic flavonoids
lipoxigenase inhibitors
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES88106495T
Other languages
English (en)
Inventor
Alexander Kover
Edwin Shen-Chou Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pennwalt Corp
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of ES2004845A4 publication Critical patent/ES2004845A4/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A HIDROBROMURO DE 7-[3-[(3,4DIHIDROXIFENETIL)AMINO]-2-HIDROXIPROPOXI]FLAVONA Y FLAVNOIDES RELACIONADOS QUE INHIBEN A LEUCOTRIENOS Y 5-LIPOXIGENASA; ALGUNOS COMPUESTOS PREFERIDOS INHIBEN TAMBIEN LA ANAFILAXIS EN RATAS.
ES88106495T 1987-04-23 1988-04-22 Flavonoides sinteticos como inhibidores de leucotrienos y 5-lipoxigenasa. Pending ES2004845A4 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4181787A 1987-04-23 1987-04-23
US07/129,014 US4889941A (en) 1987-04-23 1987-12-04 Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase

Publications (1)

Publication Number Publication Date
ES2004845A4 true ES2004845A4 (es) 1989-02-16

Family

ID=26718569

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88106495T Pending ES2004845A4 (es) 1987-04-23 1988-04-22 Flavonoides sinteticos como inhibidores de leucotrienos y 5-lipoxigenasa.

Country Status (6)

Country Link
US (1) US4889941A (es)
EP (1) EP0288077A3 (es)
JP (1) JPS63280075A (es)
DE (1) DE288077T1 (es)
ES (1) ES2004845A4 (es)
PT (1) PT87326A (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298512A (en) * 1989-04-07 1994-03-29 Pfizer Inc. Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives
DE60318237T2 (de) 2002-10-24 2008-12-18 Immupharm A/S Pharmazeutische zusammensetzungen enthaltend flavonoide und menthol
US7635779B2 (en) * 2004-10-15 2009-12-22 Council Of Scientific & Industrial Research Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents
US20060229310A1 (en) * 2004-12-14 2006-10-12 Wagenaar Frank L Antibacterial compounds
EP2057137B1 (en) 2006-08-09 2013-10-23 Council of Scientific and Industrial Research S-(+)-7-[3-n-substituted amino-2-hydroxypropoxy]flavones
JP5819196B2 (ja) * 2008-10-29 2015-11-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 液晶ディスプレイ
NZ789295A (en) 2009-04-29 2024-02-23 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184359B (en) * 1980-12-16 1984-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing substituted acyl-carbamides
US4495198A (en) * 1981-05-01 1985-01-22 Pennwalt Corporation Antihypertensive chromonoxypropanolamines
US4668805A (en) * 1981-05-01 1987-05-26 Pennwalt Corporation Chromones
US4501755A (en) * 1981-05-01 1985-02-26 Pennwalt Corporation Isoflavones useful as anti-inflammatory agents
US4668804A (en) * 1981-05-01 1987-05-26 Pennwalt Corporation Chromones
AU8045382A (en) * 1981-12-14 1983-06-23 Pennwalt Corp. Chromones
US4448729A (en) * 1982-08-25 1984-05-15 American Home Products Corporation Leucotriene antagonists
US4463176A (en) * 1982-09-13 1984-07-31 Mead Johnson & Company Process for resolution of optical isomers

Also Published As

Publication number Publication date
JPS63280075A (ja) 1988-11-17
EP0288077A3 (en) 1989-06-14
US4889941A (en) 1989-12-26
EP0288077A2 (en) 1988-10-26
DE288077T1 (de) 1989-03-09
PT87326A (pt) 1989-05-12

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