ES2001594A6 - Procedimiento para preparar 6-fenoximetil-4-hidroxitetrahidropiran-2-onas - Google Patents
Procedimiento para preparar 6-fenoximetil-4-hidroxitetrahidropiran-2-onasInfo
- Publication number
- ES2001594A6 ES2001594A6 ES8601384A ES8601384A ES2001594A6 ES 2001594 A6 ES2001594 A6 ES 2001594A6 ES 8601384 A ES8601384 A ES 8601384A ES 8601384 A ES8601384 A ES 8601384A ES 2001594 A6 ES2001594 A6 ES 2001594A6
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- radicals
- alkyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA DONDE R1 Y R 5, IGUALES O DIFERENTES, REPRESENTA HIDROGENO O RADICALES ORGANICOS SUSTITUIDOS; R2 Y R4, IGUALES O DIFERENTES, REPRESENTAN HIDROGENO O ALQUILO SUSTITUIDO, HALOGENO O ALCOXI; Y R3 REPRESENTA HIDROGENO, ALQUILO, ALQUENILO, HALOGENO O ALCOXI, HACIENDO REACCIONAR UN FENOL DE FORMULA DONDE R1 A R5 SON COMO ANTES, CON UN YODURO QUIRAL DE FORMULA DONDE R10 SIGNIFICA UN GRUPO PROTECTOR ESTABLE FRENTE A BASES Y ACIDOS DEBILES, CON LO CUAL SE OBTIENEN ETERES DE FORMULA IV QUE SE HIDROLIZAN A SEMIACETALES CORRESPONDIENTES DE FORMULA V, LOS CUALES SE OXIDAN A LACTONAS DE FORMULA VI, QUE POR HIDROLISIS ORIGINAN LOS PRODUCTOS DE FORMULA I. LAS FORMULAS IV, V Y VI SE ILUSTRAN EN LA MEMORIA. LOS PRODUCTOS OBTENIDOS SON UTILES EN MEDICAMENTOS COMO INHIBIDORES DE LA BIOSINTESIS DE LA COLESTERINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853530798 DE3530798A1 (de) | 1985-08-29 | 1985-08-29 | 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
DE19853543336 DE3543336A1 (de) | 1985-12-07 | 1985-12-07 | 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2001594A6 true ES2001594A6 (es) | 1988-06-01 |
Family
ID=25835464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8601384A Expired ES2001594A6 (es) | 1985-08-29 | 1986-08-27 | Procedimiento para preparar 6-fenoximetil-4-hidroxitetrahidropiran-2-onas |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0216127B1 (es) |
KR (1) | KR870002115A (es) |
AU (1) | AU6202986A (es) |
DE (1) | DE3674521D1 (es) |
DK (1) | DK409786A (es) |
ES (1) | ES2001594A6 (es) |
FI (1) | FI863470A (es) |
GR (1) | GR862208B (es) |
HU (1) | HUT44770A (es) |
IL (1) | IL79854A0 (es) |
NO (1) | NO863460L (es) |
NZ (1) | NZ217366A (es) |
PH (1) | PH23860A (es) |
PT (1) | PT83270B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3722809A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | 3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte |
IL90249A (en) * | 1988-05-13 | 1994-01-25 | Hoechst Ag | 4-Hydroxytetrahydropyran-2-lobes, history of appropriate dihydrocarboxylic acids and salts, processes for their preparation and pharmaceutical preparations containing them |
US5166171A (en) * | 1988-05-13 | 1992-11-24 | Hoechst Aktiengesellschaft | 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia |
NZ230121A (en) * | 1988-08-29 | 1993-08-26 | Squibb & Sons Inc | Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
DE3929913A1 (de) * | 1989-09-08 | 1991-04-04 | Hoechst Ag | 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte |
FR2653119B1 (fr) * | 1989-10-18 | 1994-08-05 | Lipha | Nouveaux aryloxy alcoyl benzenes, leurs procedes de preparation et les compositions pharmaceutiques en renfermant. |
CA2110251A1 (en) * | 1992-11-30 | 1994-05-31 | Koichi Fujimoto | Alpha, omega-diarylalkane derivatives, their preparation and their use in the treatment and prevention of circulatory diseases and psychosis |
WO2001007031A1 (fr) * | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Derives de benzene, compositions immunostimulantes ou agents de retablissement de la pharmacosensibilite les contenant |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5559180A (en) | 1978-10-30 | 1980-05-02 | Sankyo Co Ltd | 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent |
-
1986
- 1986-08-18 EP EP86111383A patent/EP0216127B1/de not_active Expired - Lifetime
- 1986-08-18 DE DE8686111383T patent/DE3674521D1/de not_active Expired - Fee Related
- 1986-08-27 IL IL79854A patent/IL79854A0/xx unknown
- 1986-08-27 HU HU863705A patent/HUT44770A/hu unknown
- 1986-08-27 GR GR862208A patent/GR862208B/el unknown
- 1986-08-27 FI FI863470A patent/FI863470A/fi not_active IP Right Cessation
- 1986-08-27 ES ES8601384A patent/ES2001594A6/es not_active Expired
- 1986-08-27 NZ NZ217366A patent/NZ217366A/xx unknown
- 1986-08-27 PH PH34188A patent/PH23860A/en unknown
- 1986-08-28 KR KR1019860007169A patent/KR870002115A/ko not_active Application Discontinuation
- 1986-08-28 NO NO863460A patent/NO863460L/no unknown
- 1986-08-28 DK DK409786A patent/DK409786A/da not_active Application Discontinuation
- 1986-08-28 PT PT83270A patent/PT83270B/pt unknown
- 1986-08-28 AU AU62029/86A patent/AU6202986A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FI863470A (fi) | 1987-03-01 |
DE3674521D1 (de) | 1990-10-31 |
EP0216127A2 (de) | 1987-04-01 |
PT83270A (de) | 1986-09-01 |
HUT44770A (en) | 1988-04-28 |
PH23860A (en) | 1989-11-23 |
EP0216127B1 (de) | 1990-09-26 |
DK409786A (da) | 1987-03-01 |
AU6202986A (en) | 1987-03-05 |
DK409786D0 (da) | 1986-08-28 |
IL79854A0 (en) | 1986-11-30 |
NZ217366A (en) | 1989-08-29 |
EP0216127A3 (en) | 1987-06-16 |
NO863460D0 (no) | 1986-08-28 |
KR870002115A (ko) | 1987-03-30 |
NO863460L (no) | 1987-03-02 |
FI863470A0 (fi) | 1986-08-27 |
GR862208B (en) | 1986-12-23 |
PT83270B (de) | 1988-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980601 |