ES2001208A6 - Procedimiento para la obtencion de derivados de la esfingosina - Google Patents

Procedimiento para la obtencion de derivados de la esfingosina

Info

Publication number
ES2001208A6
ES2001208A6 ES8601030A ES8601030A ES2001208A6 ES 2001208 A6 ES2001208 A6 ES 2001208A6 ES 8601030 A ES8601030 A ES 8601030A ES 8601030 A ES8601030 A ES 8601030A ES 2001208 A6 ES2001208 A6 ES 2001208A6
Authority
ES
Spain
Prior art keywords
azido
group
protected
compound
eliminated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601030A
Other languages
English (en)
Inventor
Richard R Schmidt
Peter Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICN Switzerland AG
Original Assignee
Solco Basel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solco Basel AG filed Critical Solco Basel AG
Publication of ES2001208A6 publication Critical patent/ES2001208A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

OBJETO DE LA SOLICITUD ES UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ESFINGOSINA, DESCRITOS EN LA SOLICITUD DE LA PATENTE EUROPEA N. 146.810 DE FORMULA. CONSISTE EN QUE, LA D-GALACTOSA SE PROTEGE EN POSCION 4, 6 Y SE OXIDA A LA CORRESPONDIENTE TEROSA PROTEGIDA EN LA POSICION 2, 4, A ESTA ULTIMA SE LE CONDENSA POR REACCION DE WITTIG UNA CADENA ALIFATICA (R3), SE TRANSFORMA EL GRUPO HIDROXILICO LIBRE EN UN GRUPO AZIDA Y SE LIBERA EL GRUPO DE PROTECCION, EL COMPUESTO OBTENIDO, 2-AZIDA-1,3-DIHIDROXILISICION-3, SE VUELVE A LIBERAR EL GRUPO HIDROXILICO DE LA POSICION 1, Y EL COMPUESTO OBTENIDO O EL COMPUESTO 2-AZIDO-1,3-DIHIDROXILICO, ANTES CITADO SE GLICOSILA CON O-TRIFLUOR O CON UN O-TRICLOROACTIMIDATO O CON UN 1-HALODERIVADO DE UNA 2,3,4,6-O-TETRAACIL-D-GLUCOSA, SE LIBERAN LOS GRUPOS ACILICOS Y EL GRUPO DE PROTECCION DE LA POSICION 3, SE TRANSFORMA CON UN ACIDO GRASO R1-OH. EL PROCEDIMIENTO SUMINISTRA, EN RELATIVAMENTE POCOS PASOS, LOS COMPUESTOS DE LA SERIE-D, TERAPEUTICAMENTE LOS ACTIVOS SIN SEPARACION DE DIASTEREOMEROS Y CON BUEN RENDIMIENTO.
ES8601030A 1985-08-13 1986-08-12 Procedimiento para la obtencion de derivados de la esfingosina Expired ES2001208A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH347285 1985-08-13
CH93886 1986-03-07

Publications (1)

Publication Number Publication Date
ES2001208A6 true ES2001208A6 (es) 1988-05-01

Family

ID=25686169

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601030A Expired ES2001208A6 (es) 1985-08-13 1986-08-12 Procedimiento para la obtencion de derivados de la esfingosina

Country Status (14)

Country Link
US (1) US4937328A (es)
EP (1) EP0212400B1 (es)
AR (1) AR242395A1 (es)
AT (1) ATE71104T1 (es)
AU (1) AU603773B2 (es)
CA (1) CA1267891A (es)
DE (1) DE3683214D1 (es)
DK (1) DK165984C (es)
ES (1) ES2001208A6 (es)
FI (1) FI82058C (es)
HU (1) HU197916B (es)
NO (1) NO163453C (es)
PL (1) PL149578B1 (es)
YU (1) YU142886A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0299201A3 (de) * 1987-06-12 1990-08-22 Wilhelm Dr. Hoerrmann Fett-Aminoalkohol enthaltendes Arzneimittel
DE3819870A1 (de) * 1987-06-12 1988-12-29 Hoerrmann Wilhelm Arzneimittel auf der basis von fett-amino-alkoholen
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
FR2673179B1 (fr) * 1991-02-21 1993-06-11 Oreal Ceramides, leur procede de preparation et leurs applications en cosmetique et en dermopharmacie.
GB9207182D0 (en) * 1992-04-01 1992-05-13 Enzymatix Ltd Glycolipids and their preparation
WO1994009020A1 (en) * 1992-10-22 1994-04-28 Kirin Beer Kabushiki Kaisha Novel shingoglycolipid and use thereof
WO1995003028A1 (en) * 1993-07-23 1995-02-02 Morris Herstein Cosmetic, skin-renewal stimulating composition with long-term irritation control
ES2117304T3 (es) * 1993-10-18 1998-08-01 Virginia Tech Intell Prop Sintesis de esfingosinas.
US5663151A (en) * 1994-03-04 1997-09-02 Bristol-Myers Squibb Company Sulfated α-glycolipid derivatives as cell adhesion inhibitors
CA2142153A1 (en) * 1994-03-04 1995-09-05 Jacques Banville Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
US5686426A (en) * 1994-11-17 1997-11-11 Bristol-Myers Squibb Company Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors
EP0994888B1 (en) 1998-05-14 2004-02-04 Cosmoferm B.V. Process for the acylation of amino alcohols
WO2000068238A1 (en) * 1999-05-10 2000-11-16 Lipiderm Ltd. Process for large scale preparation of sphingosines and ceramides
US7156661B2 (en) * 2002-08-22 2007-01-02 Align Technology, Inc. Systems and methods for treatment analysis by teeth matching

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478104B1 (fr) * 1980-03-17 1986-08-08 Merieux Inst Nouveaux derives de gangliosides, leur preparation et leur application
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten

Also Published As

Publication number Publication date
PL149578B1 (en) 1990-02-28
ATE71104T1 (de) 1992-01-15
FI863272A (fi) 1987-02-14
DK165984B (da) 1993-02-22
DE3683214D1 (de) 1992-02-13
AU603773B2 (en) 1990-11-29
DK382486D0 (da) 1986-08-11
EP0212400A2 (de) 1987-03-04
HU197916B (en) 1989-06-28
US4937328A (en) 1990-06-26
FI863272A0 (fi) 1986-08-12
NO163453C (no) 1990-05-30
AR242395A1 (es) 1993-03-31
DK165984C (da) 1993-07-19
FI82058C (fi) 1991-01-10
EP0212400B1 (de) 1992-01-02
HUT42500A (en) 1987-07-28
AU6108386A (en) 1987-02-19
PL261011A1 (en) 1987-06-01
DK382486A (da) 1987-02-14
EP0212400A3 (en) 1987-10-28
NO863251L (no) 1987-02-16
CA1267891A (en) 1990-04-17
YU142886A (en) 1988-06-30
FI82058B (fi) 1990-09-28
NO863251D0 (no) 1986-08-12
NO163453B (no) 1990-02-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990301