ES2000742A6 - Un procedimiento para preparar alcohol terciarios halogeno-bifenilos - Google Patents
Un procedimiento para preparar alcohol terciarios halogeno-bifenilosInfo
- Publication number
- ES2000742A6 ES2000742A6 ES8600557A ES8600557A ES2000742A6 ES 2000742 A6 ES2000742 A6 ES 2000742A6 ES 8600557 A ES8600557 A ES 8600557A ES 8600557 A ES8600557 A ES 8600557A ES 2000742 A6 ES2000742 A6 ES 2000742A6
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- atheriosclerosis
- therapeutically useful
- halogenated biphenyl
- tertiary halogenated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 halogenated biphenyl alcohols Chemical group 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
EL PROCEDIMIENTO DESCRITO PREPARA ALCOHOLES DE FORMULA: HACIENDO REACCIONAR EN UN DISOLVENTE ORGANICO POCO POLAR (ETERES, AROMATICOS), ENTRE C20JC Y LA TEMPERATURA DE EBULLICION DEL DISOLVENTE, UN COMPUESTO DE FORMULA: CON UN COMPUESTO ORGANOMAGNESIANO DE FORMULA R1MG-Y, EN CUYAS FORMULAS X ES CLORO O BROMO, EN POSICION O META, R Y R1, IDENTICOS O DIFERENTES, SON ALQUILO E Y ES YODO, BROMO O CLORO. PARTICULARMENTE INTERESANTE ES UN COMPUESTO DE FORMULA (I) (LLAMADO F 2833), EN EL QUE X ES CLORO EN POSICION ORTO Y R Y R1 SON METILO. LOS COMPUESTOS OBTENIDOS SON UTILES COMO MEDICAMENTOS, ESPECIALMENTE PARA TRATAR ATEROESCLEROSIS Y OBESIDAD.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8511582A FR2585350B1 (fr) | 1985-07-26 | 1985-07-26 | Alcools tertiaires halogeno biphenyles utiles en therapeutique dans le traitement de l'atherosclerose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2000742A6 true ES2000742A6 (es) | 1988-03-16 |
Family
ID=9321746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8600557A Expired ES2000742A6 (es) | 1985-07-26 | 1986-07-24 | Un procedimiento para preparar alcohol terciarios halogeno-bifenilos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4714789A (es) |
| EP (1) | EP0210886B1 (es) |
| JP (1) | JPS6229541A (es) |
| AT (1) | ATE36697T1 (es) |
| AU (1) | AU590302B2 (es) |
| CA (1) | CA1266489A (es) |
| DE (1) | DE3660589D1 (es) |
| ES (1) | ES2000742A6 (es) |
| FR (1) | FR2585350B1 (es) |
| ZA (1) | ZA865552B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2610659A1 (en) * | 2005-06-14 | 2006-12-21 | Merck Frosst Canada Ltd. | Reversible inhibitors of monoamine oxidase a and b |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH398522A (de) * | 1961-07-27 | 1966-03-15 | Sir Labo Chimico Biologi | Verfahren zur Herstellung von sekundären Alkoholen mit Anticholesterinämie-Wirkung |
| US4053639A (en) * | 1964-01-24 | 1977-10-11 | The Boots Company Limited | Therapeutically active phenylalkane derivatives |
| BE790085A (fr) * | 1971-10-15 | 1973-04-13 | Thomae Gmbh Dr K | Nouveaux 4-(4-biphenylyl)-butanols |
| US3969418A (en) * | 1972-08-17 | 1976-07-13 | Boehringer Ingelheim Gmbh | (4-Biphenylyl)-butenols |
| DE2240440A1 (de) * | 1972-08-17 | 1974-02-28 | Thomae Gmbh Dr K | Neue (4-biphenylyl)-alkohole und verfahren zu ihrer herstellung |
| DE2259243A1 (de) * | 1972-12-04 | 1974-06-06 | Thomae Gmbh Dr K | 2'-fluorbiphenyle |
| DE2341506A1 (de) * | 1973-08-16 | 1975-02-27 | Thomae Gmbh Dr K | Neue biphenylderivate und verfahren zu ihrer herstellung |
-
1985
- 1985-07-26 FR FR8511582A patent/FR2585350B1/fr not_active Expired
-
1986
- 1986-06-20 DE DE8686401369T patent/DE3660589D1/de not_active Expired
- 1986-06-20 AT AT86401369T patent/ATE36697T1/de not_active IP Right Cessation
- 1986-06-20 EP EP86401369A patent/EP0210886B1/fr not_active Expired
- 1986-07-14 US US06/884,959 patent/US4714789A/en not_active Expired - Fee Related
- 1986-07-24 JP JP61172954A patent/JPS6229541A/ja active Pending
- 1986-07-24 ES ES8600557A patent/ES2000742A6/es not_active Expired
- 1986-07-24 AU AU60523/86A patent/AU590302B2/en not_active Ceased
- 1986-07-25 CA CA000514716A patent/CA1266489A/fr not_active Expired - Fee Related
- 1986-07-25 ZA ZA865552A patent/ZA865552B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3660589D1 (en) | 1988-09-29 |
| EP0210886A1 (fr) | 1987-02-04 |
| AU6052386A (en) | 1987-01-29 |
| FR2585350B1 (fr) | 1988-11-04 |
| ZA865552B (en) | 1987-03-25 |
| CA1266489A (fr) | 1990-03-06 |
| ATE36697T1 (de) | 1988-09-15 |
| US4714789A (en) | 1987-12-22 |
| JPS6229541A (ja) | 1987-02-07 |
| FR2585350A1 (fr) | 1987-01-30 |
| EP0210886B1 (fr) | 1988-08-24 |
| AU590302B2 (en) | 1989-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted |
Owner name: PIERRE FABRE MEDICAMENT, SOCIETE ANONYME |
|
| FD1A | Patent lapsed |
Effective date: 20001102 |