ES8802217A1 - Procedimiento para preparar esteres de alcohol primario de halogeno-bifenilmetanol - Google Patents

Procedimiento para preparar esteres de alcohol primario de halogeno-bifenilmetanol

Info

Publication number
ES8802217A1
ES8802217A1 ES557813A ES557813A ES8802217A1 ES 8802217 A1 ES8802217 A1 ES 8802217A1 ES 557813 A ES557813 A ES 557813A ES 557813 A ES557813 A ES 557813A ES 8802217 A1 ES8802217 A1 ES 8802217A1
Authority
ES
Spain
Prior art keywords
treatment
derivatives
alcohols
primary
halobiphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557813A
Other languages
English (en)
Other versions
ES557813A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of ES557813A0 publication Critical patent/ES557813A0/es
Publication of ES8802217A1 publication Critical patent/ES8802217A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1742—Unsaturated ethers containing halogen containing six-membered aromatic rings with halogen atoms bound to the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LOS ESTERES DE ALCOHOL PRIMARIO DE HALOGENO-BIFENIL-METANOL (I), DONDE X ES HALOGENO Y R ACILO AMINADO ELEGIDO ENTRE (II), (III) O (IV); SE OBTIENEN HACIENDO REACCIONAR UN HALOGENURO DE HALOGENO-ACETILO X1COCH2X2, DONDE X1 Y X2 SON HALOGENOS, CON UN ALCOHOL (V), EN CANTIDADES EQUIMOLARES, EN UNA AMIDA TERCIARIA COMO DISOLVENTE, POR EJEMPLO LA N,N-DIMETILFORMAMIDA Y ENTRE C10 Y 50JC DURANTE 1 A 2 HORAS, TRAS LO CUAL, EL DERIVADO INTERMEDIO SE TRATA CON UNA AMINA SECUNDARIA O TERCIARIA EN EXCESO PARA CAPTAR EL ACIDO HALOGENADO FORMADO, Y OPCIONALMENTE SALIFICAR EL DERIVADO (I) CON ACIDO MALEICO. APLICABLE EN EL TRATAMIENTO DE LA ARTEROSCLEROSIS.
ES557813A 1985-07-08 1988-01-29 Procedimiento para preparar esteres de alcohol primario de halogeno-bifenilmetanol Expired ES8802217A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8510528A FR2584403B1 (fr) 1985-07-08 1985-07-08 Derives d'alcools primaires halogeno biphenyles utiles en therapeutique dans le traitement de l'atherosclerose

Publications (2)

Publication Number Publication Date
ES557813A0 ES557813A0 (es) 1988-04-16
ES8802217A1 true ES8802217A1 (es) 1988-04-16

Family

ID=9321137

Family Applications (4)

Application Number Title Priority Date Filing Date
ES556663A Expired ES8802294A1 (es) 1985-07-08 1986-06-25 Procedimiento para preparar derivados de alcoholes primarios de halogeno-bifenil metilo.
ES557813A Expired ES8802217A1 (es) 1985-07-08 1988-01-29 Procedimiento para preparar esteres de alcohol primario de halogeno-bifenilmetanol
ES557812A Expired ES8802216A1 (es) 1985-07-08 1988-01-29 Procedimiento para preparar derivados de alcoholes primarios de halogeno-bifenil-4-metanol
ES557811A Expired ES8802215A1 (es) 1985-07-08 1988-01-29 Procedimiento para preparar derivados de alcoholes primarios de halogeno-bifenilmetilo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES556663A Expired ES8802294A1 (es) 1985-07-08 1986-06-25 Procedimiento para preparar derivados de alcoholes primarios de halogeno-bifenil metilo.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557812A Expired ES8802216A1 (es) 1985-07-08 1988-01-29 Procedimiento para preparar derivados de alcoholes primarios de halogeno-bifenil-4-metanol
ES557811A Expired ES8802215A1 (es) 1985-07-08 1988-01-29 Procedimiento para preparar derivados de alcoholes primarios de halogeno-bifenilmetilo

Country Status (10)

Country Link
US (1) US4734417A (es)
EP (1) EP0210885B1 (es)
JP (1) JPS6210032A (es)
AT (1) ATE54445T1 (es)
AU (1) AU590295B2 (es)
CA (1) CA1270831A (es)
DE (1) DE3672538D1 (es)
ES (4) ES8802294A1 (es)
FR (1) FR2584403B1 (es)
ZA (1) ZA865075B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753262A (en) * 1995-06-07 1998-05-19 Aronex Pharmaceuticals, Inc. Cationic lipid acid salt of 3beta N- (N', N'-dimethylaminoethane) - carbamoyl!cholestrol and halogenated solvent-free preliposomal lyophilate thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2527963A (en) * 1948-06-16 1950-10-31 Parke Davis & Co beta-dimethylamino-ethyl rho-halobenzhydryl ethers and their salts
US3624142A (en) * 1964-09-10 1971-11-30 Merck & Co Inc Substituted biphenyl acetic acid derivatives
DE2328973A1 (de) * 1973-06-07 1975-01-02 Thomae Gmbh Dr K Neue biphenyl-derivate
DE2330838A1 (de) * 1973-06-16 1975-01-09 Thomae Gmbh Dr K Neue carbonsaeureester von 3-(4biphenylyl)-1-butanolen und 3-(4-biphenylyl)2-buten-1-olen
FR2476072A1 (fr) * 1980-02-18 1981-08-21 Fabre Sa Pierre Phenyl-4 benzoate de nicotinamido methyle, nouveaux derives utiles en therapeutique comme normolipemiants choleretiques
FR2498449A1 (fr) * 1981-01-23 1982-07-30 Fabre Sa Pierre Acides halogeno biphenyl carboxyliques et leurs sels utiles en therapeutique
JPS6011483A (ja) * 1983-06-29 1985-01-21 Taiho Yakuhin Kogyo Kk ピペラジン化合物

Also Published As

Publication number Publication date
EP0210885B1 (fr) 1990-07-11
ES556663A0 (es) 1988-05-01
AU590295B2 (en) 1989-11-02
FR2584403A1 (fr) 1987-01-09
EP0210885A1 (fr) 1987-02-04
ES557812A0 (es) 1988-04-16
ES557811A0 (es) 1988-04-16
CA1270831A (fr) 1990-06-26
ES557813A0 (es) 1988-04-16
ZA865075B (en) 1987-02-25
US4734417A (en) 1988-03-29
ES8802294A1 (es) 1988-05-01
AU5982186A (en) 1987-01-15
JPS6210032A (ja) 1987-01-19
ATE54445T1 (de) 1990-07-15
ES8802216A1 (es) 1988-04-16
ES8802215A1 (es) 1988-04-16
DE3672538D1 (de) 1990-08-16
FR2584403B1 (fr) 1987-10-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519