ES2000384A6 - Synergistic antiviral and antitumour compsns. - contg. cpd. with antiviral and antitumour activity, pref. xanthate, and cpd. contg. both hydrophilic and lipophilic gps., e.g. decanoic acid - Google Patents

Synergistic antiviral and antitumour compsns. - contg. cpd. with antiviral and antitumour activity, pref. xanthate, and cpd. contg. both hydrophilic and lipophilic gps., e.g. decanoic acid

Info

Publication number
ES2000384A6
ES2000384A6 ES8600811A ES8600811A ES2000384A6 ES 2000384 A6 ES2000384 A6 ES 2000384A6 ES 8600811 A ES8600811 A ES 8600811A ES 8600811 A ES8600811 A ES 8600811A ES 2000384 A6 ES2000384 A6 ES 2000384A6
Authority
ES
Spain
Prior art keywords
antiviral
antitumour
cpd
alkyl
contg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8600811A
Other languages
Spanish (es)
Inventor
Gerhard Sauer
Eberhard Amtmann
Hummel Klaus W
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CT-HOLDING SA
Original Assignee
Merz and Co GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz and Co GmbH and Co KG filed Critical Merz and Co GmbH and Co KG
Publication of ES2000384A6 publication Critical patent/ES2000384A6/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid

Abstract

(A) New antiviral and antitumour compsns. contain (1) an active substance with antiviral and antitumour activity and (2) an adjuvant cpd. which contains in its molecule at least one lipophilic- and at least one hydrophilic-gp. (B) New pharmaceutical prepns. intended to administration before, simultaneously with or after pharmaceutical prepns. with antiviral and antitumour activity, which increase the activity of the antiviral/antitumour prepns. contain as the synergistically acting active substance at least one cpd. contg. in its molecule at least one lipophilic- and at least one hydrophilic-gp. Pref. antitumour/antiviral active substances xanthate derivs. of formula (I) (R1 is norbornyl, tricyclodecyl, benzyl, 3-20C (cyclo)alkyl, furyl, pyridyl, quinuclidinyl, 3-20C alkyl substd. by at least one OH or 1-4C alkoxy or halogenation, or 3-20C cycloalkyl substd. by at least one OH, 1-4C alkoxy or 1-4C alkyl or halogen atom R2 is one equiv. of a mono- or polyvalent metal ion, 2,3-dihydroxypropyl, omega-hydroxy-(1-4C alkoxy)-methyl, or 1-6C alkyl opt. substd. by at least one OH, 1-4C alkoxy, amino, di(1-4C alkyl)amino or tri-(1-4C alkyl)amino or halogen atom). The adjuvant cpd. (component 2) pref. carries a 6-18C aliphatic gp. as the lipophilic gp. and 1-2 carboxy, sulphate, sulphonate or phospate gps. as hydrophilic gps. and may be in the form of a pharmaceutically acceptable salt.
ES8600811A 1985-08-02 1986-08-01 Synergistic antiviral and antitumour compsns. - contg. cpd. with antiviral and antitumour activity, pref. xanthate, and cpd. contg. both hydrophilic and lipophilic gps., e.g. decanoic acid Expired - Fee Related ES2000384A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3527871 1985-08-02

Publications (1)

Publication Number Publication Date
ES2000384A6 true ES2000384A6 (en) 1991-03-16

Family

ID=6277597

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600811A Expired - Fee Related ES2000384A6 (en) 1985-08-02 1986-08-01 Synergistic antiviral and antitumour compsns. - contg. cpd. with antiviral and antitumour activity, pref. xanthate, and cpd. contg. both hydrophilic and lipophilic gps., e.g. decanoic acid

Country Status (7)

Country Link
KR (1) KR860008777A (en)
AT (1) AT388499B (en)
CS (1) CS275793B6 (en)
DD (1) DD286971A5 (en)
ES (1) ES2000384A6 (en)
HU (1) HU197212B (en)
PT (1) PT83127B (en)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1140M (en) * 1961-05-16 1962-02-19 Johnson & Johnson Chemotherapeutic composition has increased efficacy.
US4164573A (en) * 1975-06-13 1979-08-14 Galinsky Alvin M Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal
IT1202370B (en) * 1976-07-12 1989-02-09 Hoffmann La Roche INJECTABLE SOLUTIONS IN WHICH THE EMOLITHIC LIFE OF NATURAL MICELLES TRAINING AGENTS IS AVOIDED BY THE ADDITION OF LIPOIDS AND RELATED PRODUCTS
JPS5940137B2 (en) * 1976-10-14 1984-09-28 武田薬品工業株式会社 Pharmaceutical composition for oral administration
JPS54122719A (en) * 1978-03-16 1979-09-22 Sankyo Co Ltd Carcinostatic agent for oral administration
JPS56100711A (en) * 1980-01-16 1981-08-12 Teijin Ltd Pharmaceutical for remedy of uterine cancer
KR870001238B1 (en) * 1980-11-26 1987-06-26 메르츠+캄패니 게엠베하 앤드 캄패니 Preparation process of xanthate
CA1174978A (en) * 1980-11-26 1984-09-25 Arthur Scherm Xanthates
US4578391A (en) * 1982-01-20 1986-03-25 Yamanouchi Pharmaceutical Co., Ltd. Oily compositions of antitumor drugs
JPS58124714A (en) * 1982-01-20 1983-07-25 Yamanouchi Pharmaceut Co Ltd Oily composition of antitumor substance
DE3218121A1 (en) * 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Pharmaceutical compositions for tumour treatment

Also Published As

Publication number Publication date
ATA208786A (en) 1988-12-15
PT83127A (en) 1986-09-01
PT83127B (en) 1989-03-30
HUT42949A (en) 1987-09-28
CS275793B6 (en) 1992-03-18
HU197212B (en) 1989-03-28
CS8605798A2 (en) 1990-10-12
AT388499B (en) 1989-06-26
DD286971A5 (en) 1991-02-14
KR860008777A (en) 1986-12-18

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Legal Events

Date Code Title Description
PC1A Transfer granted

Owner name: CT-HOLDING SA

FD1A Patent lapsed

Effective date: 20001204