EP4724786A2 - Verfahren und vorrichtung zur probenvorbereitung für die kryogene elektronenmikroskopie - Google Patents

Verfahren und vorrichtung zur probenvorbereitung für die kryogene elektronenmikroskopie

Info

Publication number
EP4724786A2
EP4724786A2 EP24820039.6A EP24820039A EP4724786A2 EP 4724786 A2 EP4724786 A2 EP 4724786A2 EP 24820039 A EP24820039 A EP 24820039A EP 4724786 A2 EP4724786 A2 EP 4724786A2
Authority
EP
European Patent Office
Prior art keywords
grid
sample
acoustic signal
acoustic transducer
receiving area
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24820039.6A
Other languages
English (en)
French (fr)
Inventor
Venkata P. DANDEY
Mario J. BORGNIA
Wyatt A. PEELE
Tony Jun Huang
Kaichun Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of EP4724786A2 publication Critical patent/EP4724786A2/de
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42Low-temperature sample treatment, e.g. cryofixation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813Producing thin layers of samples on a substrate, e.g. smearing, spinning-on

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
EP24820039.6A 2023-06-09 2024-06-06 Verfahren und vorrichtung zur probenvorbereitung für die kryogene elektronenmikroskopie Pending EP4724786A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363472113P 2023-06-09 2023-06-09
PCT/US2024/032811 WO2024254310A2 (en) 2023-06-09 2024-06-06 Method and apparatus for cryogenic-electron microscopy sample preparation

Publications (1)

Publication Number Publication Date
EP4724786A2 true EP4724786A2 (de) 2026-04-15

Family

ID=93794650

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24820039.6A Pending EP4724786A2 (de) 2023-06-09 2024-06-06 Verfahren und vorrichtung zur probenvorbereitung für die kryogene elektronenmikroskopie

Country Status (2)

Country Link
EP (1) EP4724786A2 (de)
WO (1) WO2024254310A2 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8920023B2 (en) * 2010-08-06 2014-12-30 Victor Sloan Cryogenic non destructive testing (NDT) and material treatment
GB201808639D0 (en) * 2018-05-25 2018-07-11 Additive Manufacturing Tech Ltd Additive manufacturing
WO2021217274A1 (en) * 2020-04-30 2021-11-04 The Hospital For Sick Children High-speed cryoem specimen preparation using through-grid wicking

Also Published As

Publication number Publication date
WO2024254310A3 (en) 2025-04-03
WO2024254310A2 (en) 2024-12-12

Similar Documents

Publication Publication Date Title
Tan et al. Through-grid wicking enables high-speed cryoEM specimen preparation
DE102004059856B4 (de) Verfahren zur zerstörungsfreien Untersuchung eines Prüfkörpers mittels Ultraschall
US6641540B2 (en) Miniature ultrasound transducer
Haller et al. A surface micromachined electrostatic ultrasonic air transducer
JP3964508B2 (ja) 超音波探触子及び超音波診断装置
US6860853B2 (en) Ultrasonic imaging apparatus
EP2434521A2 (de) Laseratomsonde und Laseratomsonden-Analyseverfahren
CN114323245B (zh) 一种基于机械臂移动平台的超声触感声场测量系统及方法
WO2007134051A2 (en) High frequency ultrasound transducers
JPH01500294A (ja) 超音波撮像装置と撮像方法
WO2024254310A2 (en) Method and apparatus for cryogenic-electron microscopy sample preparation
US20140072476A1 (en) Ionization device, mass spectrometer including the ionization device, and image generation system
JP7335876B2 (ja) 噴射の閉ループ流体速度制御のためのシステム及び方法
JP2002089619A (ja) アクティブ除振装置、モード行列の算出方法およびこれらを用いた露光装置
WO2021217274A1 (en) High-speed cryoem specimen preparation using through-grid wicking
DE102014103945A1 (de) Vorrichtung zur zerstörungsfreien Ultraschallprüfung von Werkstücken mit einer verbesserten Handhabbarkeit sowie Verfahren hierzu
Liang et al. Flexible pico-liter acoustic droplet ejection based on high-frequency ultrasound transducer
Sinton et al. Time-resolved acoustic microscopy of polymer coatings
CA2577280C (en) Sample movement control unit, sample movement parameters acquisition method, and sample movement control method
Chono et al. Novel atomization method based on SAW streaming
JP4521584B2 (ja) 超音波顕微鏡を使用した音速測定方法、その音速測定装置、超音波顕微鏡を使用した音速像取得方法およびその画像診断装置
US5988001A (en) Method of locating a particle on a surface
JP2004221966A (ja) 超音波振動子の加工方法
Berners et al. An ultrasonic time-of-flight system for hand movement measurement
JP2005291828A (ja) 超音波顕微鏡を使用した音速測定方法、その音速測定装置、画像診断方法およびその画像診断装置

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20251208

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR