EP4694863A1

EP4694863A1 - A composition for improving scalp health, and a method of improving scalp health using the same

Info

Publication number: EP4694863A1
Application number: EP23932421.3A
Authority: EP
Inventors: Yingxin Ma; Mengmeng Zhang; Xuejing LI
Original assignee: Henkel AG and Co KGaA
Current assignee: Henkel AG and Co KGaA
Priority date: 2023-04-12
Filing date: 2023-04-12
Publication date: 2026-02-18
Also published as: WO2024212124A1; WO2024212124A9; CN121358463A; JP2026512058A

Abstract

Provided is a composition for improving scalp health, comprising a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein. Further, provided is a method of improving scalp health, comprising: applying such a composition to the scalp and/or hair.

Description

A composition for improving scalp health, and a method of improving scalp health using the same

Technical field

The present invention relates to a composition for improving scalp health, and a method of improving scalp health. In particular, the present invention relates to a composition for improving scalp health, comprising a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein; and a method of improving scalp health comprising applying such a composition to the scalp and/or hair.

Background of the invention

Sensitive scalp, which means that the scalp is extremely itchy, is common in recent years. Itchy scalp is one of the most critical discomforts, which can lead to serious impairment of quality of life. According to the statistical data in the world, the prevalence of scalp pruritus is estimated to range from 13%to 45%. Thus, there is a growing demand in the market for treating itchy scalp.
Currently, antifungal agents, antihistamines and moisturizers are the most widely used solutions for treating itchy scalp. However, the antifungal agents and the antihistamines can merely treat the symptoms of itchy scalp, and the antifungal agents can even damage scalp microbiome; and the effects of the moisturizers are limited.
In view of the above, it would be desirable to provide a composition for improving scalp health, and a method of improving scalp health, which can effectively treat itchy scalp.
Summary of the invention
In a first aspect, the present invention provides a composition for improving scalp health, comprising a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein.
In a second aspect, the present invention provides a method of improving scalp health, comprising: applying a composition according to the present invention to the scalp and/or hair.
All of the composition and the method according to the present invention are based on the following surprising discoveries of the inventors: a composition comprising a combination of a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention can effectively treat itchy scalp; and in particular, it can effectively reduce itch severity, increase the number of the subjects who are recovered from itchiness to non-itch, reduce the species richness of itchy scalp, reduce the relative abundance of Clostridium sensu stricto 1, Leptolyngbya, Acinetobacter, Enterobacter, Azoarcus, Bacteroides, Comamonas, Pannonibacter, Novosphingobium, Klebsiella, Escherichia-Shigella, Corynebacterium and/or Sporolactobacillus (which are enriched on itchy scalp) on itchy scalp, increase the relative abundance of Cutibacterium, Staphylococus and Lawsonella (which are enriched on normal scalp) on itchy scalp, reduce the pathways related to biosynthesis of butirosin and neomycin on itchy scalp, and/or increase the pathways related to amino acid and biotin metabolism pathways of itchy scalp.
BRIEF DESCRIPTION OF THE FIGURES
FIG. 1 shows changes of the Faith_pd and the Observed ASVs of Groups 1 and 3, which reflect the decrease in species richness of itchy scalp.
FIG. 2 shows regulation of pathway Ko00524 by Groups 1 and 3.

Detailed description of the invention

It is to be understood by one of ordinary skill in the art that the present discussion is a description of exemplary embodiments only, and is not intended as limiting the broader aspects of the present invention. Each aspect so described may be combined with any other aspect or aspects unless clearly indicated to the contrary. In particular, any feature indicated as being preferred or advantageous may be combined with any other feature or features indicated as being preferred or advantageous.
Unless specified otherwise, as used herein, the terms “a” , “an” and “the” include both singular and plural referents.
The terms “comprising” and “comprises” as used herein are synonymous with “including” , “includes” , “containing” or “contains” , and are inclusive or open-ended and do not exclude additional, non-recited members, elements or process steps.
Unless specified otherwise, the recitation of numerical end points includes all numbers and fractions subsumed within the respective ranges, as well as the recited end points.
Unless otherwise defined, all terms used in the disclosing the invention, including technical and scientific terms, have the meaning as commonly understood by one of the ordinary skill in the art to which this invention belongs.
According to the present invention, surprisingly, the inventors of the present invention found that a composition comprising a combination of a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention can effectively treat itchy scalp, especially by affecting scalp microbiome and relative metabolism pathways.
In a first aspect, the present disclosure is generally directed to a composition for improving scalp health, comprising a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein.
1, 2-alkanediol having 6 to 16 carbon atoms per molecule
According to the present invention, the composition comprises a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule.
Preferably, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1, 2-hexanediol, 1, 2-heptanediol, 1, 2-octanediol, 1, 2-nonanediol, 1, 2-decanediol, 1, 2-undecanediol, 1, 2-dodecanediol, 1, 2-tetradecanediol, 1, 2-hexadecanediol and their mixtures. More preferably, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1, 2-hexanediol, 1, 2-octanediol, 1, 2-decanediol, 1, 2-dodecanediol, and their mixtures. Further preferably, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1, 2-octanediol, 1, 2-decanediol, 1, 2-dodecandiol, and their mixtures. Most preferably, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is 1, 2-decanediol.
In a preferred embodiment of the present invention, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form selected from the group consisting of the following forms: 1, 2-decanediol available under the trade name of SymClariol from Symrise Company, a mixture of 1, 2-hexanediol and 1, 2-octanediol available under the trade name of SymDiol 68 from Symrise Company, a mixture of 1, 2-hexanediol, 1, 2-octanediol and tropolone available under the trade name of SymDiol 68T from Symrise Company, a mixture of 1, 2-octanediol, 1, 2-hexanediol and methybenzyl alcohol available under the trade name of SymTriol from Symrise Company, a mixture of phenoxyethanol, 1, 2-decanediol and 1, 2-hexanediol available under the trade name of SymOcide PS from Symrise Company, and their mixtures. In a more preferred embodiments of the present invention, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form selected from the group consisting of the following forms: 1, 2-decanediol available under the trade name of SymClariol from Symrise Company, a mixture of phenoxyethanol, 1, 2-decanediol and 1, 2-hexanediol available under the trade name of SymOcide PS from Symrise Company, and their mixtures. In a further preferred embodiments of the present invention, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form of 1, 2-decanediol available under the trade name of SymClariol from Symrise Company.
Preferably, the content of the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is from 0.01%by weight to 10.0%by weight, preferably from 0.02%by weight to 5.0%by weight, and more preferably from 0.025%by weight to 2.0%by weight, each based on the total weight of the composition. If the content of the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is higher than 10.0%by weight, based on the total weight of the composition, the composition will be not stable in a long term. If the content of the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is lower than 0.01%by weight, based on the total weight of the composition, it will not achieve the advantageous technical effects of the present invention.
In a most preferred embodiment of the present invention, the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form of 1, 2-decanediol under the trade name of SymClariol; and the content of SymClariol is from 0.1%by weight to 2.0%by weight, preferably from 0.3%by weight to 1.5%by weight, and more preferably from 0.4%by weight to 1.3%by weight, each based on the total weight of the composition.
Hydrolyzed yeast protein
According to the present invention, the composition comprises a hydrolyzed yeast protein.
As used herein, the term “hydrolyzed yeast protein” refers to any hydrolyzed yeast protein which is conventionally used in a hair and/or scalp care product, and preferably a substance having CAS No. 100684-36-4.
Preferably, in the present invention, the hydrolyzed yeast protein is used in the form of a mixture comprising a hydrolyzed yeast protein, 1, 2-pentanediol and 1, 3-butanediol; preferably, the mixture is available under the trade name of Relipidium, in particular Relipidium A00265 and/or Relipidium BC10096, from BASF; and more preferably, the mixture is available under the trade name of Relipidium BC10096.
In a preferred embodiment of the present invention, the content of the hydrolyzed yeast protein is from 0.01%by weight to 10.0%by weight, preferably from 0.02%by weight to 5.0%by weight, and more preferably from 0.03%by weight to 1.0%by weight, each based on the total weight of the composition. If the content of the hydrolyzed yeast protein is higher than 10.0%by weight, based on the total weight of the composition, the composition obtained will have a problem of incompatibility. If the content of the hydrolyzed yeast protein is lower than 0.01%by weight, based on the total weight of the composition, it will not achieve the advantageous technical effects of the present invention.
In a most preferred embodiment of the present invention, the hydrolyzed yeast protein is used in the form of Relipidium; and the content of Relipidium is from 0.1%by weight to 1.0%by weight, preferably from 0.3%by weight to 0.7%by weight, and more preferably from 0.4%by weight to 0.6%by weight, each based on the total weight of the composition.
In a preferable embodiment of the present invention, the composition comprises 1, 2-decanediol under the trade name of SymClariol from Symrise Company, and hydrolyzed yeast protein which is used in the form of Relipidium; and preferably, the content of SymClariol is from 0.1%by weight to 2.0%by weight, preferably from 0.3%by weight to 1.5%by weight, and more preferably from 0.4%by weight to 1.3%by weight, each based on the total weight of the composition, and/or preferably, the content of Relipidium is from 0.1%by weight to 1.0%by weight, preferably from 0.3%by weight to 0.7%by weight, and more preferably from 0.4%by weight to 0.6%by weight, each based on the total weight of the composition.
Additive
The composition according to the present invention may further comprise an additive which is conventionally used in a hair and/or scalp care product, including but not limited to water, a surfactant, a hair humectant, a thickening agent, a preservative, a perfume, a pH adjuster, and/or a skin humectant.
The presence, type and amount of the additive may be determined by a specialist in the art according to actual needs, as long as they do not negatively affect the purpose of the present invention. For example, when the composition is a shampoo, it may further comprise a surfactant, a hair humectant, a thickening agent, a preservative and/or a perfume; and when the composition is a scalp care product, such as a scalp serum, it may further comprise a thickening agent, a pH adjuster, a skin humectant, a preservative and/or a perfume.
The composition according to the present invention may be a hair care, styling and/or color product, and/or a scalp care product, such as a shampoo, a hair conditioner, a hair styling product, a hair color product, a scalp serum, and/or a scalp spray. Preferably, the composition according to the present invention is a shampoo or a scalp serum.
The composition according to the present invention may be prepared according to conventional methods in the art, such as by mixing all the components in the composition at room temperature. Moreover, the composition according to the present invention may be used according to conventional methods in the art.
The composition according to the present invention can effectively treat itchy scalp; and in particular, it can effectively reduce itch severity, increase the number of the subjects who are recovered from itchiness to non-itch, reduce the species richness of itchy scalp, reduce the relative abundance of Clostridium sensu stricto 1, Leptolyngbya, Acinetobacter, Enterobacter, Azoarcus, Bacteroides, Comamonas, Pannonibacter, Novosphingobium, Klebsiella, Escherichia-Shigella, Corynebacterium and/or Sporolactobacillus (which are enriched on itchy scalp) on itchy scalp, increase the relative abundance of Cutibacterium, Staphylococus and Lawsonella (which are enriched on normal scalp) on itchy scalp, reduce the pathways related to biosynthesis of butirosin and neomycin on itchy scalp, and/or increase the pathways related to amino acid and biotin metabolism pathways of itchy scalp.
In a second aspect, the present disclosure is generally directed to a method of improving scalp health, comprising: applying a composition according to the present invention to the scalp and/or hair.
With regard to the further preferred embodiments of the method of improving scalp health, and the hair care, styling and/or color product, what has been said about the composition according to the present invention applies mutatis mutandis.
The invention will be illustrated in more details by way of the following examples which are not to be understood as limiting the concept of the invention.
Examples
1. Preparation of Compositions 1 to 6
The following raw materials were used in the examples.
Water was obtained from Henkel Company.
Hostapur OS liq. was obtained from Clariant Company.
Pureact WS-70 was obtained from Innospec Active Chemical Company.
Coco-Glucoside 52%was obtained from BASF Company.
Cocamidopropyl betaine 40%was obtained from BASF Company.
Glycerin 99.5%was obtained from KLK Oleo Company.
Merquat 281 was obtained from Lubrizol Company.
Glucamate DOE-120 was obtained from Lubrizol Company.
Nutrilan Keratin W PP was obtained from BASF Company.
Lactic acid 80%DAB was obtained from Purac Biochem Company.
PEG-7 Glyceryl Cocoate was obtained from BASF Company.
Castor oil hydrog., 40 EO was obtained from Croda Company.
Parfum 711495 Wonderland was obtained from Symrise Company.
Na-benzoate was obtained from DSM Company.
SymClariol 344028 was obtained from Symprise Company.
Relipidium BC10096 was obtained from BASF Company.
Carbomer 50000 -60000 mPas was obtained from OQWMA Company.
Sodium hydroxide pearls was obtained from Merck Company.
Citric acid Monohydrate Regular was obtained from Inter-Harz Company
D-Panthenol 75%was obtained from BASF Company.
Propanediol-1, 2 was obtained from DOW Company.
Sensiva SC 50 was obtained from Ashland Company.
Caprylyl glycol was obtained from Symprise Company.
SymDiol 68 was obtained from Symprise Company.
Table 1: Composition 1 (shampoo, a comparative composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein)
Note: all Qty%herein means the percent ratio of the weight.
Table 2: Composition 2 (scalp serum, a comparative composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein)
Table 3: Composition 3 (shampoo, a comparative composition containing a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule without a hydrolyzed yeast protein)
Table 4: Composition 4 (scalp serum, a comparative composition containing a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule without a hydrolyzed yeast protein)
Table 5: Composition 5 (shampoo, a composition containing both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein)
Table 6: Composition 6 (scalp serum, a composition containing both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein)
Compositions 1 to 4 as shown above in Tables 1-4 (all of which are comparative compositions) and Compositions 5 to 6 as shown above in Tables 5-6 (both of which are compositions for improving scalp health according to the present invention) were prepared as follows: at room temperature, dispersing surfactant or carbomer in water by stirring; adding other substances including humectant, preservative and actives (if any) one by one when stirring; and then adding sodium hydroxide and/or fragrance into the mixture.
2. Measuring method and results of itch severity
The severity of itch was measured using a numerical score of 1–10 of Visual Analogue Scale (VAS) , which is a method for the assessment of pruritus. The VAS is a 10-cm long line, on which individuals indicated the intensity of pruritus by crossing the line at the point that corresponded to their pruritus severity. Individuals have been informed that the beginning of the scale refers to no pruritus (0 points) and the end to the most severe pruritus they can imagine (10 points) . For example, the measuring method can be found in Reich A, Heisig M, Phan N Q, et al. Visual analogue scale: evaluation of the instrument for the assessment of pruritus [J] . Acta Derm Venereol, 2012, 92 (5) : 497-501.
In this test, “itchy scalp” refers to the scalp of the individual whose VAS > 6, and “normal scalp” refers to the non-itchy scalp of the individual who has no scalp diseases such as dandruff and seborrheic dermatitis, according to evaluation made by professional dermatologist and individual’s subjective statement, and whose VAS ≤ 2.
125 Chinese female itchy subjects (VAS > 6) , who were screened out through filling out 3S questionnaire and scoring itchy serverities by themselves and evaluating by professional dermatologist in terms of scalp condition and pruritus degree, were tested; and they were divided into three groups randomly: Group 1, including 40 subjects; Group 2, including 43 subjects; and Group 3, including 42 subjects. Group1 used compositions 1 and 2, Group 2 used compositions 3 and 4, and Group 3 used compositions 5 and 6. All the subjects used both the shampoo and the scalp serum according to the following methods:
(1) Shampoo
Shampooing every 2 days and washing hair twice every time; in particular, wetting the hair, applying the shampoo to the hair, rinsing the hair thoroughly, then applying the shampoo again, and rinsing the hair thoroughly after massage.
(2) Leave-on scalp serum
After shampooing as above, drying the scalp and hair, taking the soybean-to peanut-sized scalp serum, placing it on the fingertips, then applying it on the mid of vertex with both hands, massaging scalp until the serum was completely absorbed. Then repeat the similar process, apply serum to the both sides of the mid of Vertex, Opisthotic area, mid of Hinter Hauptstachel, both sides of Hinter Hauptstachel and the itchy area and make sure the serum was completely absorbed.
After 28 days, all the subjects scored the VAS again according to the above method. The average VAS results of Groups 1 and 3 on Day 0 and on Day 28 were recorded in Table 7.
Table 7. VAS on Day 0 and on Day 28 of Groups 1 and 3
From the above, it can be seen that as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein (such as Group 1) , the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention (such as Group 3) reduces the itch severity more effectively.
3. Measuring method and results of number of subjects who are recovered from itchiness to non-itch
The numbers of subjects who were recovered from itchiness to non-itch (i.e. VAS ≤ 2) of Groups 1-3 were also counted, and the results were recorded in Table 8.
Table 8. Number of itchy subjects on Day 0 and number of subjects who were recovered on Day 28
From the above, it can be seen that as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein (such as Group 1) and the composition containing a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule without a hydrolyzed yeast protein (such as Group 2) , there were more itchy subjects recovered from itchiness to non-itch after using the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention (such as Group 3) .
4. Measuring method and results of species richness of itchy scalp
The 125 Chinese female subjects with itchy scalp (VAS > 6) were also tested in microbiota.
First of all, on Day 0, microorganism collection areas were marked on the scalps of all the subjects.
To collect as many microorganisms as possible in the microorganism collection areas, each of the sites of the itchy subjects (hereinafter referred to as “itchy sample” ) , whose area was 6 cm x 0.5 cm, was scraped with 5 sterile cotton swabs dipped in sterile saline for at least ten times. In total, 125 itchy samples were collected. The bacterial DNAs of all the samples were extracted according to slightly modified Guidelines for DNeasy Blood &Tissue Kit (Qiagen, #69506) , and all the samples were subjected to a high-throughput sequencing in Shanghai Personalbio Technology Co., Ltd with the Illumina Novaseq sequencing platform and PE250 strategy. Then, all the samples were used for droplet digital PCR quantification, and all the microorganism data obtained from the above were analyzed using USEARCH (version 11.0.667) and QIIME2 platform (version 2021.04, https: //qiime2. org) .
On the Day 28 after using the shampoo and serum as above, the same process and analysis were done as above.
In order to analyze the diversity of the sequencing results of 125 samples, the Faith_pd and the Observed ASVs were analyzed.
The Faith_pd index not only indicates the richness, but also indicates the relationship of species on the evolutionary tree; and the more different places in the evolutionary tree come from, the higher the pd score. Observed ASVs only characterizes species information without abundance information, and it intuitively displays the number of species in the community.
As shown in Figure 1, the Faith_pd and the Observed ASVs results showed that, as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein (such as Group 1) , both the Faith_pd and the Observed ASVs were decreased more significantly after using the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention (such as Group 3) for 28 days as above.
Moreover, according to PCT/CN2022/104287 (which is a co-pending PCT international application of Henkel, and is incorporated herein by reference) , it is believed that the microorganisms of the itchy scalp have higher species richness than those of normal scalp.
Thus, the above results demonstrated that, as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein, the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention can reduce species richness of the itchy scalp more significantly, and thus can treat itchy scalp more effectively.
5. Measuring method and results of relative abundance of bacteria on itchy scalp
The relative abundances of the bacterial species composition of the 125 Chinese female subjects with itchy scalp (VAS > 6) were also analyzed.
The relative abundance results of the bacterial species composition on the itchy scalp showed that, as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein (such as Group 1) and the composition containing a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule without a hydrolyzed yeast protein (such as Group 2) , the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention (such as Group 3) decreases the relative abundance of Clostridium sensu stricto 1, Leptolyngbya, Acinetobacter, Enterobacter, Azoarcus, Bacteroides, Comamonas, Pannonibacter, Novosphingobium, Klebsiella, Escherichia-Shigella, Corynebacterium and/or Sporolactobacillus (which are enriched on itchy scalp) on itchy scalp more significantly, and increases the relative abundance of Cutibacterium, Staphylococus and Lawsonella (which are enriched on normal scalp) on itchy scalp more significantly. Moreover, from Table 9, it can be seen that as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein (such as Group 1) and the composition containing a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule without a hydrolyzed yeast protein (such as Group 2) , the number of down-regulated ASVs enriched on itchy scalp was higher and the number of up-regulated ASVs enriched on itchy scalp was lower after using the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention (such as Group 3) .
Thus, based on the invention of PCT/CN2022/104287, it can be concluded that as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein and the composition containing a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule without a hydrolyzed yeast protein, the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention can treat itchy scalp more effectively.
Table 9. The changes of ASVs originally enriched on itchy scalp in the three groups
6. Measuring method and results of metabolism pathways
To investigate the functional potential of scalp microbial communities, ASV abundance files and representative sequence files of 125 samples obtained above were analyzed based on PICRUST2 analysis.
As shown in Figure 2, the metabolism pathway results showed that, as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein (such as Group 1) , after using the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention (such as Group 3) , biosynthesis of butirosin and/or neomycin pathway (Ko00524) were downregulated in the itchy scalp more significantly, and the metabolic pathways of amino acid, including alanine, aspartate and glutamate metabolism, lysine biosynthesis, D- glutamine and D-glutamate metabolism, and biotin metabolism and thiamine metabolism were upregulated more significantly. Thus, based on the invention of PCT/CN2022/104287, it can be concluded that as compared with the composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein, the composition comprising both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein according to the present invention can treat itchy scalp more effectively.
To sum up, as compared with a composition containing neither a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule nor a hydrolyzed yeast protein, and a composition containing a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule without a hydrolyzed yeast protein, the composition according to the present invention containing both a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule (such as SymClariol) and a hydrolyzed yeast protein (such as Relipidium) can treat itchy scalp more effectively and thus can improve scalp health.
Although some preferred embodiments have been described, many modifications and variations may be made thereto in light of the above teachings. It is therefore to be understood that the invention may be practiced otherwise than as specifically described without departing from the scope of the appended claims.

Claims

A composition for improving scalp health, comprising a 1, 2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein.
The composition according to claim 1, wherein the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1, 2-hexanediol, 1, 2-heptanediol, 1, 2-octanediol, 1, 2-nonanediol, 1, 2-decanediol, 1, 2-undecanediol, 1, 2-dodecanediol, 1, 2-tetradecanediol, 1, 2-hexadecanediol and their mixtures; preferably, it is selected from the group consisting of 1, 2-hexanediol, 1, 2-octanediol, 1, 2-decanediol, 1, 2-dodecanediol, and their mixtures; more preferably, it is selected from the group consisting of 1, 2-octanediol, 1, 2-decanediol, 1, 2-dodecandiol, and their mixtures; and most preferably, it is 1, 2-decanediol.
The composition according to claim 1 or 2, wherein the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form selected from the group consisting of the following forms: 1, 2-decanediol available under the trade name of SymClariol from Symrise Company, a mixture of 1, 2-hexanediol and 1, 2-octanediol available under the trade name of SymDiol 68 from Symrise Company, a mixture of 1, 2-hexanediol, 1, 2-octanediol and tropolone available under the trade name of SymDiol 68T from Symrise Company, a mixture of 1, 2-octanediol, 1, 2-hexanediol and methybenzyl alcohol available under the trade name of SymTriol from Symrise Company, a mixture of phenoxyethanol, 1, 2-decanediol and 1, 2-hexanediol available under the trade name of SymOcide PS from Symrise Company, and their mixtures; preferably, it is used in the form selected from the group consisting of the following forms: 1, 2-decanediol available under the trade name of SymClariol from Symrise Company, a mixture of phenoxyethanol, 1, 2-decanediol and 1, 2-hexanediol available under the trade name of SymOcide PS from Symrise Company, and their mixtures; and more preferably, it is used in the form of 1, 2-decanediol available under the trade name of SymClariol from Symrise Company.
The composition according to any one of claims 1 to 3, wherein the hydrolyzed yeast protein is a substance having CAS No. 100684-36-4, which is preferably used in the form of a mixture comprising a hydrolyzed yeast protein, 1, 2-pentanediol and 1, 3-butanediol; and preferably, the mixture is available under the trade name of Relipidium, from BASF.
The composition according to any one of claims 1 to 4, wherein the content of the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is from 0.01%by weight to 10.0%by weight, preferably from 0.02%by weight to 5.0%by weight, and more preferably from 0.025%by weight to 2.0%by weight, each based on the total weight of the composition.
The composition according to any one of claims 1 to 5, wherein the content of the hydrolyzed yeast protein is from 0.01%by weight to 10.0%by weight, preferably from 0.02%by weight to 5.0%by weight, and more preferably from 0.03%by weight to 1.0%by weight, each based on the total weight of the composition.
The composition according to any one of claims 1 to 6, wherein the 1, 2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form of 1, 2-decanediol under the trade name of SymClariol, and the hydrolyzed yeast protein is used in the form of Relipidium; preferably, the content of SymClariol is from 0.1%by weight to 2.0%by weight, preferably from 0.3%by weight to 1.5%by weight, and more preferably from 0.4%by weight to 1.3%by weight, each based on the total weight of the composition, and/or preferably, the content of Relipidium is from 0.1%by weight to 1.0%by weight, preferably from 0.3%by weight to 0.7%by weight, and more preferably from 0.4%by weight to 0.6%by weight, each based on the total weight of the composition.
The composition according to any one of claims 1 to 7, further comprising an additive selected from the group consisting of a surfactant, a hair humectant, a thickening agent, a preservative, a perfume, a pH adjuster, and/or a skin humectant.
The composition according to any one of claims 1 to 8, which is a hair care, styling and/or color product, and/or a scalp care product, such as a shampoo, a hair conditioner, a hair styling product, a hair color product, a scalp serum, and/or a scalp spray.
A method of improving scalp health, comprising: applying a composition according to any one of claims 1 to 9 to the scalp and/or hair.