EP4561995B1 - 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents - Google Patents

1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents

Info

Publication number
EP4561995B1
EP4561995B1 EP23750964.1A EP23750964A EP4561995B1 EP 4561995 B1 EP4561995 B1 EP 4561995B1 EP 23750964 A EP23750964 A EP 23750964A EP 4561995 B1 EP4561995 B1 EP 4561995B1
Authority
EP
European Patent Office
Prior art keywords
hydroxy
methyl
methylene
bis
phenylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP23750964.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP4561995A1 (en
EP4561995C0 (en
Inventor
Mauro Botta
Lorenzo Tei
Fabio Carniato
Zsolt Baranyai
Mariangela BOCCALON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of EP4561995A1 publication Critical patent/EP4561995A1/en
Application granted granted Critical
Publication of EP4561995B1 publication Critical patent/EP4561995B1/en
Publication of EP4561995C0 publication Critical patent/EP4561995C0/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP23750964.1A 2022-07-28 2023-07-28 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents Active EP4561995B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22187403 2022-07-28
PCT/EP2023/071027 WO2024023314A1 (en) 2022-07-28 2023-07-28 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents

Publications (3)

Publication Number Publication Date
EP4561995A1 EP4561995A1 (en) 2025-06-04
EP4561995B1 true EP4561995B1 (en) 2026-05-27
EP4561995C0 EP4561995C0 (en) 2026-05-27

Family

ID=82780974

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23750964.1A Active EP4561995B1 (en) 2022-07-28 2023-07-28 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents

Country Status (10)

Country Link
US (1) US12358880B2 (enExample)
EP (1) EP4561995B1 (enExample)
JP (1) JP2025524769A (enExample)
KR (1) KR20250040575A (enExample)
CN (1) CN119343336A (enExample)
AU (1) AU2023313342A1 (enExample)
CA (1) CA3252691A1 (enExample)
IL (1) IL317339A (enExample)
MX (1) MX2024015341A (enExample)
WO (1) WO2024023314A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025163025A1 (en) 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof
CN119499407B (zh) * 2024-11-25 2026-04-07 中国科学院精密测量科学与技术创新研究院 一种Fe基T7肽靶向脑胶质瘤小分子磁共振造影剂及其制备合成方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3624859A4 (en) 2017-05-19 2021-03-03 The Research Foundation for The State University of New York COMPOUNDS FOR USE AS IRON (III) MRT CONTRAST AGENTS
EP3880635B1 (en) 2018-11-12 2023-01-04 Bracco Imaging SPA Chelating aazta conjugate, complexes thereof and use

Also Published As

Publication number Publication date
IL317339A (en) 2025-01-01
AU2023313342A1 (en) 2024-12-19
JP2025524769A (ja) 2025-08-01
WO2024023314A1 (en) 2024-02-01
US20250163007A1 (en) 2025-05-22
EP4561995A1 (en) 2025-06-04
US12358880B2 (en) 2025-07-15
CA3252691A1 (en) 2024-02-01
EP4561995C0 (en) 2026-05-27
CN119343336A (zh) 2025-01-21
KR20250040575A (ko) 2025-03-24
MX2024015341A (es) 2025-02-10

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