CA3252691A1 - 1,4-BIS-(2-HYDROXY-BENZYL)-1,4,7-TRIAZACYCLONONANE DERIVATIVES AND SIMILAR COMPOUNDS AS LIGANDS IN IRON (III) COMPLEXES, INTENDED FOR USE AS MRI CONTRAST AGENTS - Google Patents
1,4-BIS-(2-HYDROXY-BENZYL)-1,4,7-TRIAZACYCLONONANE DERIVATIVES AND SIMILAR COMPOUNDS AS LIGANDS IN IRON (III) COMPLEXES, INTENDED FOR USE AS MRI CONTRAST AGENTSInfo
- Publication number
- CA3252691A1 CA3252691A1 CA3252691A CA3252691A CA3252691A1 CA 3252691 A1 CA3252691 A1 CA 3252691A1 CA 3252691 A CA3252691 A CA 3252691A CA 3252691 A CA3252691 A CA 3252691A CA 3252691 A1 CA3252691 A1 CA 3252691A1
- Authority
- CA
- Canada
- Prior art keywords
- hydroxy
- methylene
- methyl
- bis
- diyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22187403.5 | 2022-07-28 | ||
| EP22187403 | 2022-07-28 | ||
| PCT/EP2023/071027 WO2024023314A1 (en) | 2022-07-28 | 2023-07-28 | 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3252691A1 true CA3252691A1 (en) | 2024-02-01 |
Family
ID=82780974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3252691A Pending CA3252691A1 (en) | 2022-07-28 | 2023-07-28 | 1,4-BIS-(2-HYDROXY-BENZYL)-1,4,7-TRIAZACYCLONONANE DERIVATIVES AND SIMILAR COMPOUNDS AS LIGANDS IN IRON (III) COMPLEXES, INTENDED FOR USE AS MRI CONTRAST AGENTS |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12358880B2 (enExample) |
| EP (1) | EP4561995B1 (enExample) |
| JP (1) | JP2025524769A (enExample) |
| KR (1) | KR20250040575A (enExample) |
| CN (1) | CN119343336A (enExample) |
| AU (1) | AU2023313342A1 (enExample) |
| CA (1) | CA3252691A1 (enExample) |
| IL (1) | IL317339A (enExample) |
| MX (1) | MX2024015341A (enExample) |
| WO (1) | WO2024023314A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025163025A1 (en) | 2024-01-31 | 2025-08-07 | Bracco Imaging Spa | Pyridophane macrocyclic ligands and fe(iii) complexes thereof |
| CN119499407B (zh) * | 2024-11-25 | 2026-04-07 | 中国科学院精密测量科学与技术创新研究院 | 一种Fe基T7肽靶向脑胶质瘤小分子磁共振造影剂及其制备合成方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3624859A4 (en) | 2017-05-19 | 2021-03-03 | The Research Foundation for The State University of New York | COMPOUNDS FOR USE AS IRON (III) MRT CONTRAST AGENTS |
| EP3880635B1 (en) | 2018-11-12 | 2023-01-04 | Bracco Imaging SPA | Chelating aazta conjugate, complexes thereof and use |
-
2023
- 2023-07-28 IL IL317339A patent/IL317339A/en unknown
- 2023-07-28 CN CN202380045442.5A patent/CN119343336A/zh active Pending
- 2023-07-28 CA CA3252691A patent/CA3252691A1/en active Pending
- 2023-07-28 KR KR1020247038908A patent/KR20250040575A/ko active Pending
- 2023-07-28 WO PCT/EP2023/071027 patent/WO2024023314A1/en not_active Ceased
- 2023-07-28 JP JP2024571340A patent/JP2025524769A/ja active Pending
- 2023-07-28 AU AU2023313342A patent/AU2023313342A1/en active Pending
- 2023-07-28 EP EP23750964.1A patent/EP4561995B1/en active Active
- 2023-07-28 US US18/871,962 patent/US12358880B2/en active Active
-
2024
- 2024-12-10 MX MX2024015341A patent/MX2024015341A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL317339A (en) | 2025-01-01 |
| AU2023313342A1 (en) | 2024-12-19 |
| JP2025524769A (ja) | 2025-08-01 |
| EP4561995B1 (en) | 2026-05-27 |
| WO2024023314A1 (en) | 2024-02-01 |
| US20250163007A1 (en) | 2025-05-22 |
| EP4561995A1 (en) | 2025-06-04 |
| US12358880B2 (en) | 2025-07-15 |
| EP4561995C0 (en) | 2026-05-27 |
| CN119343336A (zh) | 2025-01-21 |
| KR20250040575A (ko) | 2025-03-24 |
| MX2024015341A (es) | 2025-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11357873B2 (en) | Chiral cyclen compounds and their uses | |
| EP0299795B1 (en) | Aminopolycarboxylic acids and derivatives thereof | |
| US11021451B2 (en) | Contrast agents | |
| DE3855177T2 (de) | Makrozyklische tetraaza-verbindungen | |
| AU2016368545C1 (en) | Dimeric contrast agents | |
| US12358880B2 (en) | 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(III) complexes for use as MRI contrast agents | |
| SI8810742A (en) | Process for the preparation of the new nitrogen-containing cyclic ligands,metallic complexes formed by these ligands and diagnostic composition containing these complexes. | |
| FI96416C (fi) | Heterosykliset kelaatin muodostavat yhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät diagnostiset aineet | |
| JPH03504608A (ja) | テトラ‐アザマクロサイクルおよびその製造法 | |
| Gugliotta et al. | AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents | |
| US20240228524A1 (en) | Iron(iii) macrocyclic complexes with mixed hyroxyl pendants as mri contrast agents | |
| WO2025120059A1 (en) | Compound for disorders associated with excess and/or accumulation of iron ions | |
| HK40118708A (en) | 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents | |
| US20110021765A1 (en) | Fluorinated lanthanide probes for 19f magnetic resonance applications | |
| AU617338B2 (en) | Aminopolycarboxylic acids and derivatives thereof | |
| WO2025163025A1 (en) | Pyridophane macrocyclic ligands and fe(iii) complexes thereof | |
| Dickins et al. | A new chiral lanthanide NMR probe for the determination of the enantiomeric purity of α-hydroxy acids and the absolute configuration of α-amino acids in water | |
| Brücher et al. | The Future of Biomedical Imaging: Synthesis and Chemical Properties of the | |
| EP3386953B1 (en) | Contrast agents | |
| Barnett et al. | Syntheses and fluorescence of salicylaldimine schiff base derivatives of 1, 1′‐di (aminoethylaminocarbonylalkyl)‐2, 2′‐biimidazole | |
| IE71186B1 (en) | Aminopolycarboxylic acids and derivatives thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A00 | Application filed |
Free format text: ST27 STATUS EVENT CODE: A-0-1-A10-A00-A101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION RECEIVED - PCT Effective date: 20241107 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20241107 Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST TO REGISTER A DOCUMENT RECEIVED Effective date: 20241107 |
|
| A00 | Application filed |
Free format text: ST27 STATUS EVENT CODE: A-1-1-A10-A00-A102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: COMPLIANCE REQUIREMENTS DETERMINED MET Effective date: 20250203 |
|
| A15 | Pct application entered into the national or regional phase |
Free format text: ST27 STATUS EVENT CODE: A-1-1-A10-A15-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: NATIONAL ENTRY REQUIREMENTS DETERMINED COMPLIANT Effective date: 20250203 |
|
| P18 | Priority claim added or amended |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P18-P105 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIORITY CLAIM REQUIREMENTS DETERMINED COMPLIANT Effective date: 20250203 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REGISTER A DOCUMENT REQUIREMENTS DETERMINED COMPLIANT Effective date: 20250203 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250217 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 2ND ANNIV.) - STANDARD Year of fee payment: 2 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250718 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250718 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260528 |